Publications (2015)

  1. Carriere, C. H., Kang, N. H., and Niles, L. P. (2015) Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson's disease. Brain Res. [PM:26740407].
  2. Peltier, G., Aro, E. M., and Shikanai, T. (2015) NDH-1 and NDH-2 Plastoquinone Reductases in Oxygenic Photosynthesis. Annu. Rev. Plant Biol. [PM:26735062].
  3. Cela, O., Scrima, R., Pazienza, V., Merla, G., Benegiamo, G., Augello, B., Fugetto, S., Menga, M., Rubino, R., Fuhr, L., Relogio, A., Piccoli, C., Mazzoccoli, G., and Capitanio, N. (2015) Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos. Biochim. Biophys. Acta 1863:596-606. [PM:26732296].
  4. Duong, A., Che, Y., Ceylan, D., Pinguelo, A., Andreazza, A. C., Trevor, Y. L., and Berk, M. (2015) Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder. Psychiatry Res. [PM:26723136].
  5. Cordoba, J. P., Marchetti, F., Soto, D., Martin, M. V., Pagnussat, G. C., and Zabaleta, E. (2015) The CA domain of the respiratory complex I is required for normal embryogenesis in Arabidopsis thaliana. J. Exp. Bot. [PM:26721503].
  6. Hirst, J. and Roessler, M. M. (2015) Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I. Biochim. Biophys. Acta [PM:26721206].
  7. Duong, A., Che, Y., Ceylan, D., Pinguelo, A., Andreazza, A. C., Trevor, Y. L., and Berk, M. (2015) Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder. Psychiatry Res. [PM:26723136].
  8. Cordoba, J. P., Marchetti, F., Soto, D., Martin, M. V., Pagnussat, G. C., and Zabaleta, E. (2015) The CA domain of the respiratory complex I is required for normal embryogenesis in Arabidopsis thaliana. J. Exp. Bot. [PM:26721503].
  9. Hirst, J. and Roessler, M. M. (2015) Energy conversion, redox catalysis and generation of reactive oxygen species by respiratory complex I. Biochim. Biophys. Acta [PM:26721206].
  10. Vorburger, T., Nedielkov, R., Brosig, A., Bok, E., Schunke, E., Steffen, W., Mayer, S., Gotz, F., Moller, H. M., and Steuber, J. (2015) Role of the Na-translocating NADH:quinone oxidoreductase in voltage generation and Na extrusion in Vibrio cholerae. Biochim. Biophys. Acta [PM:26721205].
  11. Urra, F. A., Cordova-Delgado, M., Lapier, M., Orellana-Manzano, A., Acevedo-Arevalo, L., Pessoa-Mahana, H., Gonzalez-Vivanco, J. M., Martinez-Cifuentes, M., Ramirez-Rodriguez, O., Millas-Vargas, J. P., Weiss-Lopez, B., Pavani, M., Ferreira, J., and Araya-Maturana, R. (2015) Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicol. Appl. Pharmacol. [PM:26712467].
  12. Castro, P. J., Silva, A. F., Marreiros, B. C., Batista, A. P., and Pereira, M. M. (2015) Respiratory complex I: A dual relation with H and Na? Biochim. Biophys. Acta [PM:26711319].
  13. Hellwig, P., Kriegel, S., and Friedrich, T. (2015) Infrared spectroscopic studies on reaction induced conformational changes in the NADH ubiquinone oxidoreductase (complex I). Biochim. Biophys. Acta [PM:26702948].
  14. Okuda, K., Murai, M., Aburaya, S., Aoki, W., and Miyoshi, H. (2015) Reduction of synthetic ubiquinone QT catalyzed by bovine mitochondrial complex I is decoupled with proton translocation. Biochemistry [PM26701224].
  15. Shinzawa-Itoh, K., Shimomura, H., Yanagisawa, S., Shimada, S., Takahashi, R., Oosaki, M., Ogura, T., and Tsukihara, T. (2015) Purification of active respiratory supercomplex from bovine heart mitochondria enables functional studies. J. Biol. Chem. [PM:26698328].
  16. Ferrer-Cortes, X., Narbona, J., Bujan, N., Matalonga, L., Del, T. M., Arranz, J. A., Riudor, E., Garcia-Cazorla, A., Jou, C., O'Callaghan, M., Pineda, M., Montero, R., Arias, A., Garcia-Villoria, J., Alston, C. L., Taylor, R. W., Briones, P., Ribes, A., and Tort, F. (2015) A leaky splicing mutation in NFU1 is associated with a particular biochemical phenotype. Consequences for the diagnosis. Mitochondrion. 26:72-80. [PM:26688339].
  17. Gueguen, N., Desquiret-Dumas, V., Leman, G., Chupin, S., Baron, S., Nivet-Antoine, V., Vessieres, E., Ayer, A., Henrion, D., Lenaers, G., Reynier, P., and Procaccio, V. (2015) Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice. PLoS. ONE. 10:e0144290- [PM:26684010].
  18. Friedrich, T., Dekovic, D. K., and Burschel, S. (2015) Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (respiratory complex I). Biochim. Biophys. Acta [PM:26682761].
  19. Giordano, L., Deceglie, S., d'Adamo, P., Valentino, M. L., La, M. C., Fracasso, F., Roberti, M., Cappellari, M., Petrosillo, G., Ciaravolo, S., Parente, D., Giordano, C., Maresca, A., Iommarini, L., Del, D., V, Ghelli, A. M., Salomao, S. R., Berezovsky, A., Belfort, R., Jr., Sadun, A. A., Carelli, V., Loguercio, P. P., and Cantatore, P. (2015) Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways. Cell Death. Dis. 6:e2021- [PM26673666].
  20. Belevich, N. P., Bertsova, Y. V., Verkhovskaya, M. L., Baykov, A. A., and Bogachev, A. V. (2015) Identification of the coupling step in Na-translocating NADH:quinone oxidoreductase from real-time kinetics of electron transfer. Biochim. Biophys. Acta 1857:141-149. [PM:26655930].
  21. Jiang, P., Jin, X., Peng, Y., Wang, M., Liu, H., Liu, X., Zhang, Z., Ji, Y., Zhang, J., Liang, M., Zhao, F., Sun, Y. H., Zhang, M., Zhou, X., Chen, Y., Mo, J. Q., Huang, T., Qu, J., and Guan, M. X. (2015) The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation. Hum. Mol. Genet. [PM:26647310].
  22. Kostyrko, V. A., Bertsova, Y. V., Serebryakova, M. V., Baykov, A. A., and Bogachev, A. V. (2015) NqrM (DUF539) Protein is Required for Maturation of Bacterial Na+-translocating NADH:quinone Oxidoreductase. J. Bacteriol. [PM:26644436].
  23. Lark, D. S., Reese, L. R., Ryan, T. E., Torres, M. J., Smith, C. D., Lin, C. T., and Neufer, P. D. (2015) Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I. Front Physiol 6:332- [PM:26635618].
  24. Murai, M. and Miyoshi, H. (2015) Current topics on inhibitors of respiratory complex I. Biochim. Biophys. Acta [PM:26625959].
  25. Degli, E. M. (2015) Genome analysis of structure-function relationships in respiratory complex I, an ancient bioenergetic enzyme. Genome Biol. Evol. [PM:26615219].
  26. Muller, F. E., Braun, M., Syring, I., Klumper, N., Schmidt, D., Perner, S., Hauser, S., Muller, S. C., and Ellinger, J. (2015) NDUFA4 expression in clear cell renal cell carcinoma is predictive for cancer-specific survival. Am. J. Cancer Res. 5:2816-2822. [PM:26609487].
  27. Johnson, J., Lee, W., Frazier, A. E., Vaghjiani, V., Laskowski, A., Rodriguez, A. L., Cagnone, G., McKenzie, M., White, S. J., Nisbet, D. R., Thorburn, D. R., and St, J. J. (2015) Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells Dev. [PM:26608563].
  28. Feuer, W. J., Schiffman, J. C., Davis, J. L., Porciatti, V., Gonzalez, P., Koilkonda, R. D., Yuan, H., Lalwani, A., Lam, B. L., and Guy, J. (2015) Gene Therapy for Leber Hereditary Optic Neuropathy: Initial Results. Ophthalmology [PM:26606867].
  29. Grunewald, A., Rygiel, K. A., Hepplewhite, P. D., Morris, C. M., Picard, M., and Turnbull, D. M. (2015) Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons. Ann. Neurol. [PM:26605748].
  30. Cazzaniga, M. and Bonanni, B. (2015) Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin. Biomed. Res. Int. 2015:972193- [PM:26605341].
  31. Dunn, E. A., Cook, G. M., and Heikal, A. (2015) Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins. J. Microbiol. Methods [PM:26593449].
  32. Jones, A. J., Blaza, J. N., Bridges, H. R., May, B., Moore, A. L., and Hirst, J. (2015) A Self-Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone-10 Cycling between Complex I and the Alternative Oxidase. Angew. Chem. Int. Ed Engl. [PM:26592861].
  33. Vinogradov, A. D. and Grivennikova, V. G. (2015) Oxidation of NADH and ROS production by respiratory complex I. Biochim. Biophys. Acta [PM:26571336].
  34. Luo, X., Li, R., and Yan, L. J. (2015) Roles of Pyruvate, NADH, and Mitochondrial Complex I in Redox Balance and Imbalance in beta Cell Function and Dysfunction. J. Diabetes Res. 2015:512618- [PM:26568959].
  35. Zimmermann, F. A., Neureiter, D., Feichtinger, R. G., Trost, A., Sperl, W., Kofler, B., and Mayr, J. A. (2015) Deficiency of respiratory chain complex I in Hashimoto thyroiditis. Mitochondrion. 26:1-6. [PM:26554844].
  36. Negida, A., Menshawy, A., El, A. G., Elfouly, Y., Hani, Y., Hegazy, Y., El, G. S., Fouda, S., and Rashad, Y. (2015) Coenzyme Q10 for Patients with Parkinson's disease: A Systematic Review and Meta-analysis. CNS. Neurol. Disord. Drug Targets. [PM:26553164].
  37. Zhang, Z., Ni, J., Zhang, J., Tang, W., Li, X., Wu, Z., and Zhang, C. (2015) A haplotype in the 5'-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese. J. Affect. Disord. 190:329-332. [PM:26544616].
  38. Shahraki, K., Goudarzi, P. K., Makateb, A., Shirzadi, K., Darian, E. K., Khosravifard, K., and Jadidi, K. (2015) The expression of mitochondrial complexes I and III correlates with prognosis or diagnosis in retinoblastoma: immunohistochemical and histopathological parameters. Tumour. Biol. [PM:26541759].
  39. Philley, J. V., Kannan, A., Qin, W., Sauter, E. R., Ikebe, M., Hertweck, K. L., Troyer, D. A., Semmes, O. J., and Dasgupta, S. (2015) Complex-I alteration and enhanced mitochondrial fusion are associated with prostate cancer progression. J. Cell Physiol [PM:26530043].
  40. Schimmeyer, J., Bock, R., and Meyer, E. H. (2015) L-Galactono-1,4-lactone dehydrogenase is an assembly factor of the membrane arm of mitochondrial complex I in Arabidopsis. Plant Mol. Biol. [PM:26520835].
  41. Shikanai, T. (2015) Chloroplast NDH: A different enzyme with a structure similar to that of respiratory NADH dehydrogenase. Biochim. Biophys. Acta [PM:26519774].
  42. Forkink, M., Basit, F., Teixeira, J., Swarts, H. G., Koopman, W. J., and Willems, P. H. (2015) Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells. Redox. Biol. 6:607-616. [PM:26516986].
  43. Yamori, W., Shikanai, T., and Makino, A. (2015) Corrigendum: Photosystem I cyclic electron flow via chloroplast NADH dehydrogenase-like complex performs a physiological role for photosynthesis at low light. Sci. Rep. 5:15593- [PM:26513004].
  44. Schockel, L., Glasauer, A., Basit, F., Bitschar, K., Truong, H., Erdmann, G., Algire, C., Hagebarth, A., Willems, P. H., Kopitz, C., Koopman, W. J., and Heroult, M. (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11- [PM:26500770].
  45. Kruse, S. E., Karunadharma, P. P., Basisty, N., Johnson, R., Beyer, R. P., Maccoss, M. J., Rabinovitch, P. S., and Marcinek, D. J. (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell [PM:26498839].
  46. Van Bergen, N. J., Crowston, J. G., Craig, J. E., Burdon, K. P., Kearns, L. S., Sharma, S., Hewitt, A. W., Mackey, D. A., and Trounce, I. A. (2015) Measurement of Systemic Mitochondrial Function in Advanced Primary Open-Angle Glaucoma and Leber Hereditary Optic Neuropathy. PLoS. ONE. 10:e0140919- [PM:26496696].
  47. Chaube, B., Malvi, P., Vikram, S. S., Mohammad, N., Singh, M. A., and Bhat, M. K. (2015) Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression. Oncotarget. [PM:26484566].
  48. Fromm, S., Going, J., Lorenz, C., Peterhansel, C., and Braun, H. P. (2015) Depletion of the "gamma-type carbonic anhydrase-like" subunits of complex I affects central mitochondrial metabolism in Arabidopsis thaliana. Biochim. Biophys. Acta 1857:60-71. [PM:26482706].
  49. Ding, W., Xu, C., Wang, B., and Zhang, M. (2015) Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation. Med. Sci. Monit. 21:3136-3143. [PM:26474533].
  50. Rocha, M. C., Grady, J. P., Grunewald, A., Vincent, A., Dobson, P. F., Taylor, R. W., Turnbull, D. M., and Rygiel, K. A. (2015) A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis. Sci. Rep. 5:15037- [PM:26469001].
  51. Yu, J., Xu, H., Shen, X., and Jiang, H. (2015) Ghrelin protects MES23.5 cells against rotenone via inhibiting mitochondrial dysfunction and apoptosis. Neuropeptides [PM:26459609].
  52. Liu, K. Y., Mistry, R. J., Aguirre, C. A., Fasouli, E. S., Thomas, M. G., Klamt, F., Ramsden, D. B., and Parsons, R. B. (2015) Nicotinamide N-methyltransferase increases complex I activity in SH-SY5Y cells via sirtuin 3. Biochem. Biophys. Res. Commun. 467:491-496. [PM:26456643].
  53. Al-Lahham, R., Deford, J. H., and Papaconstantinou, J. (2015) Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway. Mol. Cell Endocrinol. [PM:26454089].
  54. Robb, E. L., Gawel, J. M., Aksentijevic, D., Cocheme, H. M., Stewart, T. S., Shchepinova, M. M., Qiang, H., Prime, T. A., Bright, T. P., James, A. M., Shattock, M. J., Senn, H. M., Hartley, R. C., and Murphy, M. P. (2015) Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radic. Biol. Med. 89:883-894. [PM:26454075].
  55. Zhang, B., Chu, W., Wei, P., Liu, Y., and Wei, T. (2015) Xanthohumol induces generation of reactive oxygen species and triggers apoptosis through inhibition of mitochondrial electron transfer chain complex I. Free Radic. Biol. Med. 89:486-497. [PM:26453927].
  56. Peragallo, J. H. and Newman, N. J. (2015) Is there treatment for Leber hereditary optic neuropathy? Curr. Opin. Ophthalmol. 26:450-457. [PM:26448041].
  57. Daniel, R., Singh, M., and O'Rourke, K. (2015) Another "Complex" Case: Complex I Deficiency Secondary to Acyl-CoA Dehydrogenase 9 Mutation. Am. J. Med. Sci. 350:423-424. [PM:26445304].
  58. Yu, H., Koilkonda, R. D., Chou, T. H., Porciatti, V., Mehta, A., Hentall, I. D., Chiodo, V. A., Boye, S. L., Hauswirth, W. W., Lewin, A. S., and Guy, J. (2015) Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice. Proc. Natl. Acad. Sci. U. S. A 112:E5689-E5698. [PM:26438859].
  59. Fernandez-Aguera, M. C., Gao, L., Gonzalez-Rodriguez, P., Pintado, C. O., Arias-Mayenco, I., Garcia-Flores, P., Garcia-Perganeda, A., Pascual, A., Ortega-Saenz, P., and Lopez-Barneo, J. (2015) Oxygen Sensing by Arterial Chemoreceptors Depends on Mitochondrial Complex I Signaling. Cell Metab 22:825-837. [PM:26437605].
  60. Uddin, A., Mazumder, T. H., Choudhury, M. N., and Chakraborty, S. (2015) Codon bias and gene expression of mitochondrial ND2 gene in chordates. Bioinformation. 11:407-412. [PM:26420922].
  61. Plaza, D. M., Martin, M. P., Tapia, J. A., Ortega, F. C., Balao da Silva, C. C., and Pena, F. J. (2015) Inhibition of Mitochondrial Complex I Leads to Decreased Motility and Membrane Integrity Related to Increased Hydrogen Peroxide and Reduced ATP Production, while the Inhibition of Glycolysis Has Less Impact on Sperm Motility. PLoS. ONE. 10:e0138777- [PM:26407142].
  62. Jung, S. Y., Lee, K. W., Choi, S. M., and Yang, E. J. (2015) Bee Venom Protects against Rotenone-Induced Cell Death in NSC34 Motor Neuron Cells. Toxins. (Basel) 7:3715-3726. [PM:26402700].
  63. Letts, J. A. and Sazanov, L. A. (2015) Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions. Curr. Opin. Struct. Biol. 33:135-145. [PM:26387075].
  64. Marthandan, S., Priebe, S., Groth, M., Guthke, R., Platzer, M., Hemmerich, P., and Diekmann, S. (2015) Hormetic effect of rotenone in primary human fibroblasts. Immun. Ageing 12:11- [PM:26380578].
  65. Messaoudi, N., Gautier, V., Dairou, J., Mihoub, M., Lelandais, G., Bouloc, P., Landoulsi, A., and Richarme, G. (2015) Fermentation and Alternative Respiration Compensate for NADH Dehydrogenase Deficiency in a Prokaryotic Model of DJ-1 Associated Parkinsonism. Microbiology [PM:26377309].
  66. Li, D., She, X., and Calderone, R. (2015) Functional diversity of complex I subunits in Candida albicans mitochondria. Curr. Genet. [PM:26373419].
  67. Zhu, J., King, M. S., Yu, M., Klipcan, L., Leslie, A. G., and Hirst, J. (2015) Structure of subcomplex Ibeta of mammalian respiratory complex I leads to new supernumerary subunit assignments. Proc. Natl. Acad. Sci. U. S. A 112:12087-12092. [PM:26371297].
  68. van der Lee, R., Szklarczyk, R., Smeitink, J., Smeets, H. J., Huynen, M. A., and Vogel, R. (2015) Transcriptome analysis of complex I-deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system. BMC. Genomics 16:691- [PM:26369791].
  69. de, H. R., Russel, F. G., and Smeitink, J. A. (2015) Gait analysis in a mouse model resembling Leigh disease. Behav. Brain Res. 296:191-198. [PM:26363424].
  70. Yamori, W., Shikanai, T., and Makino, A. (2015) Photosystem I cyclic electron flow via chloroplast NADH dehydrogenase-like complex performs a physiological role for photosynthesis at low light. Sci. Rep. 5:13908- [PM:26358849].
  71. Varghese, F., Atcheson, E., Bridges, H. R., and Hirst, J. (2015) Characterization of clinically identified mutations in NDUFV1, the flavin-binding subunit of respiratory complex I, using a yeast model system. Hum. Mol. Genet. 24:6350-6360. [PM:26345448].
  72. Li, Y., Beckman, K. B., Caberto, C., Kazma, R., Lum-Jones, A., Haiman, C. A., Marchand, L. L., Stram, D. O., Saxena, R., and Cheng, I. (2015) Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort. PLoS. ONE. 10:e0136796- [PM:26340450].
  73. Chrysostomou, A., Grady, J. P., Laude, A., Taylor, R. W., Turnbull, D. M., and Lax, N. Z. (2015) Investigating complex I deficiency in Purkinje cells and synapses in patients with mitochondrial disease. Neuropathol. Appl. Neurobiol. [PM:26337858].
  74. Chen, S., Gan, S. R., Cai, P. P., Ni, W., Zhou, Q., Dong, Y., Wang, N., and Wu, Z. Y. (2015) Mitochondrial NADH Dehydrogenase Subunit 3 Polymorphism Associated with an Earlier Age at Onset in Male Machado-Joseph disease Patients. CNS. Neurosci. Ther. [PM:26336829].
  75. Bartolucci, M., Ravera, S., Garbarino, G., Ramoino, P., Ferrando, S., Calzia, D., Candiani, S., Morelli, A., and Panfoli, I. (2015) Functional Expression of Electron Transport Chain and FF -ATP Synthase in Optic Nerve Myelin Sheath. Neurochem. Res. [PM:26334391].
  76. Zhang, W., Hou, L., Wang, T., Lu, W., Tao, Y., Chen, W., Du, X., and Huang, Y. (2015) The expression characteristics of mt-ND2 gene in chicken. Mitochondrial. DNA1-6. [PM:26332376].
  77. Sharma, V., Belevich, G., Gamiz-Hernandez, A. P., Rog, T., Vattulainen, I., Verkhovskaya, M. L., Wikstrom, M., Hummer, G., and Kaila, V. R. (2015) Redox-induced activation of the proton pump in the respiratory complex I. Proc. Natl. Acad. Sci. U. S. A 112:11571-11576. [PM:26330610].
  78. Chen, T., Wu, Q., Zhang, Y., and Zhang, D. (2015) NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition. Brain Res. 1625:102-110. [PM:26327164].
  79. Manjeri, G. R., Rodenburg, R. J., Blanchet, L., Roelofs, S., Nijtmans, L. G., Smeitink, J. A., Driessen, J. J., Koopman, W. J., and Willems, P. H. (2015) Increased mitochondrial ATP production capacity in brain of healthy mice and a mouse model of isolated complex I deficiency after isoflurane anesthesia. J. Inherit. Metab Dis. [PM:26310962].
  80. Ji, M., Liang, Y., Gu, Z., and Li, X. (2015) Inhibitory Effects of Amorphigenin on the Mitochondrial Complex I of Culex pipiens pallens Coquillett (Diptera: Culicidae). Int. J. Mol. Sci. 16:19713-19727. [PM:26307964].
  81. Rafikov, R., Sun, X., Rafikova, O., Louise, M. M., Desai, A. A., Khalpey, Z., Yuan, J. X., Fineman, J. R., and Black, S. M. (2015) Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells. Redox. Biol. 6:278-286. [PM:26298201].
  82. Lin, B. Y. and Kao, M. C. (2015) Therapeutic applications of the TAT-mediated protein transduction system for complex I deficiency and other mitochondrial diseases. Ann. N. Y. Acad. Sci. [PM:26273800].
  83. Buathong, S., Leelayoova, S., Mungthin, M., Naaglor, T., Taamasri, P., Suwannahitatorn, P., and Tan-Ariya, P. (2015) Development and evaluation of PCR methods based on cytochrome c oxidase subunit one (cox1) and NADH dehydrogenase subunit one gene (nad1) to detect Opisthorchis viverrini in human fecal samples. Parasitol. Res. 114:3547-3549. [PM:26239798].
  84. Liu, Y., Sun, J. D., Song, L. K., Li, J., Chu, S. F., Yuan, Y. H., and Chen, N. H. (2015) Environment-contact administration of rotenone: A new rodent model of Parkinson's disease. Behav. Brain Res. 294:149-161. [PM:26239001].
  85. Hirschhauser, C., Bornbaum, J., Reis, A., Bohme, S., Kaludercic, N., Menabo, R., Di, L. F., Boengler, K., Shah, A. M., Schulz, R., and Schmidt, H. H. (2015) NOX4 in Mitochondria: Yeast Two-Hybrid-Based Interaction with Complex I Without Relevance for Basal Reactive Oxygen Species? Antioxid. Redox. Signal. [PM:26237157].
  86. Lemire, B. D. (2015) Glutathione metabolism links FOXRED1 to NADH:ubiquinone oxidoreductase (complex I) deficiency: A hypothesis. Mitochondrion. 24:105-112. [PM:26235939].
  87. Nishiyama, S., Ohba, H., Kanazawa, M., Kakiuchi, T., and Tsukada, H. (2015) Comparing alpha7 nicotinic acetylcholine receptor binding, amyloid-beta deposition, and mitochondria complex-I function in living brain: A PET study in aged monkeys. SYNAPSE 69:475-483. [PM:26234533].
  88. Jiang, P., Liang, M., Zhang, J., Gao, Y., He, Z., Yu, H., Zhao, F., Ji, Y., Liu, X., Zhang, M., Fu, Q., Tong, Y., Sun, Y., Zhou, X., Huang, T., Qu, J., and Guan, M. X. (2015) Prevalence of Mitochondrial ND4 Mutations in 1281 Han Chinese Subjects With Leber's Hereditary Optic Neuropathy. Invest Ophthalmol. Vis. Sci. 56:4778-4788. [PM:26218905].
  89. Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., and Jackson-Lewis, V. R. (2015) Oxidative stress and Parkinson's disease. Front Neuroanat. 9:91- [PM:26217195].
  90. De, R. E., Checchetto, V., Franchin, C., Bergantino, E., Berto, P., Szabo, I., Giacometti, G. M., Arrigoni, G., and Costantini, P. (2015) [NiFe]-hydrogenase is essential for cyanobacterium Synechocystis sp. PCC 6803 aerobic growth in the dark. Sci. Rep. 5:12424- [PM:26215212].
  91. Granatiero, V., Giorgio, V., Cali, T., Patron, M., Brini, M., Bernardi, P., Tiranti, V., Zeviani, M., Pallafacchina, G., De, S. D., and Rizzuto, R. (2015) Reduced mitochondrial Ca transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase. Cell Death. Differ. [PM:26206091].
  92. Andalib, S., Talebi, M., Sakhinia, E., Farhoudi, M., Sadeghi-Bazargani, H., and Gjedde, A. (2015) Mitochondrial DNA T4216C and A4917G variations in multiple sclerosis. J. Neurol. Sci. [PM:26201854].
  93. Reeve, A. K., Ludtmann, M. H., Angelova, P. R., Simcox, E. M., Horrocks, M. H., Klenerman, D., Gandhi, S., Turnbull, D. M., and Abramov, A. Y. (2015) Aggregated alpha-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons. Cell Death. Dis. 6:e1820- [PM:26181201].
  94. Matus-Ortega, M. G., Cardenas-Monroy, C. A., Flores-Herrera, O., Mendoza-Hernandez, G., Miranda, M., Gonzalez-Pedrajo, B., Vazquez-Meza, H., and Pardo, J. P. (2015) New complexes containing the internal alternative NADH dehydrogenase (Ndi1) in mitochondria of Saccharomyces cerevisiae. Yeast [PM:26173916].
  95. Sena, F. V., Batista, A. P., Catarino, T., Brito, J. A., Archer, M., Viertler, M., Madl, T., Cabrita, E. J., and Pereira, M. M. (2015) Type-II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction. Mol. Microbiol. [PM:26172206].
  96. Kim, H. K., Mendonca, K. M., Howson, P. A., Brotchie, J. M., and Andreazza, A. C. (2015) The link between mitochondrial complex I and brain-derived neurotrophic factor in SH-SY5Y ce. Eur. J. Pharmacol. 764:379-384. [PM:26164791].
  97. Averet, N., Jobin, M. L., Devin, A., and Rigoulet, M. (2015) Proton pumping complex I increases growth yield in Candida utilis. Biochim. Biophys. Acta 1847:1320-1326. [PM:26164102].
  98. Hearn, J. M., Romero-Canelon, I., Munro, A. F., Fu, Y., Pizarro, A. M., Garnett, M. J., McDermott, U., Carragher, N. O., and Sadler, P. J. (2015) Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proc. Natl. Acad. Sci. U. S. A 112:E3800-E3805. [PM:26162681].
  99. Kelly, B., Tannahill, G. M., Murphy, M. P., and O'Neill, L. A. (2015) Metformin Inhibits the Production of Reactive Oxygen Species from NADH:ubiquinone Oxidoreductase to Limit Induction of IL-1beta, and Boosts IL-10 in LPS-activated Macrophages. J. Biol. Chem. [PM:26152715].
  100. Soto, D., Cordoba, J. P., Villarreal, F., Bartoli, C., Schmitz, J., Maurino, V. G., Braun, H. P., Pagnussat, G. C., and Zabaleta, E. (2015) Functional characterization of mutants affected in the carbonic anhydrase domain of the respiratory complex I in Arabidopsis thaliana. Plant J. [PM:26148112].

  101. Kriegel, S., Srour, B., Steimle, S., Friedrich, T., and Hellwig, P. (2015) Involvement of acidic amino acid residues in Zn2+ binding to respiratory complex I. Chembiochem. [PM:26147723].
  102. Steuber, J., Vohl, G., Muras, V., Toulouse, C., Claussen, B., Vorburger, T., and Fritz, G. (2015) The structure of Na+-translocating of NADH:ubiquinone oxidoreductase of Vibrio cholerae: implications on coupling between electron transfer and Na+ transport. Biol. Chem. [PM:26146127].
  103. Hanapi, U. K., Desa, M. N., Ismail, A., and Mustafa, S. (2015) A higher sensitivity and efficiency of common primer multiplex PCR assay in identification of meat origin using NADH dehydrogenase subunit 4 gene. J. Food Sci. Technol. 52:4166-4175. [PM:26139881].
  104. Zhu, S. and Vik, S. B. (2015) Constraining the Lateral Helix of Respiratory Complex I by Cross-linking Does Not Impair Enzyme Activity or Proton Translocation. J. Biol. Chem. [PM:26134569].
  105. Kuhn, K., Obata, T., Feher, K., Bock, R., Fernie, A. R., and Meyer, E. H. (2015) Complete mitochondrial complex I deficiency induces an upregulation of respiratory fluxes that is abolished by traces of functional complex I. Plant Physiol [PM:26134164].
  106. Cossard, R., Esposito, M., Sellem, C. H., Pitayu, L., Vasnier, C., Delahodde, A., and Dassa, E. P. (2015) Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases. Front Genet. 6:206- [PM:26124772].
  107. Steimle, S., Schnick, C., Burger, E. M., Nuber, F., Kramer, D., Dawitz, H., Brander, S., Matlosz, B., Schafer, J., Maurer, K., Glessner, U., and Friedrich, T. (2015) Cysteine scanning reveals minor local rearrangements of the horizontal helix of respiratory complex I. Mol. Microbiol. [PM:26115017].
  108. Liu, Y., Zhang, R. Y., Zhao, J., Dong, Z., Feng, D. Y., Wu, R., Shi, M., and Zhao, G. (2015) Ginsenoside Rd Protects SH-SY5Y Cells against 1-Methyl-4-phenylpyridinium Induced Injury. Int. J. Mol. Sci. 16:14395-14408. [PM:26114390].
  109. Low Wang, C. C., Galinkin, J. L., and Hiatt, W. R. (2015) Toxicity of a novel therapeutic agent targeting mitochondrial complex I. Clin. Pharmacol. Ther. [PM:26108785].
  110. Rafiq, J., Duno, M., Ostergaard, E., Ravn, K., Vissing, C. R., Wibrand, F., and Vissing, J. (2015) Exercise Intolerance and Myoglobinuria Associated with a Novel Maternally Inherited MT-ND1 Mutation. JIMD. Rep. [PM:26108648].
  111. Vazquez, E. J., Berthiaume, J., Kamath, V., Achike, O., Buchanan, E., Montano, M., Chandler, M. P., Miyagi, M., and Rosca, M. G. (2015) Mitochondrial complex I defect and increased fatty acid oxidation enhance protein lysine acetylation in the diabetic heart. Cardiovasc. Res. [PM:26101264].
  112. Akarsu, S., Torun, D., Erdem, M., Kozan, S., Akar, H., and Uzun, O. (2015) Mitochondrial complex I and III mRNA levels in bipolar disorder. J. Affect. Disord. 184:160-163. [PM:26093828].
  113. Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D., Yamazaki, Y., Kanekiyo, T., Bu, G., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P., Pang, Y. P., Hua, D. H., and Trushina, E. (2015) Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease. EBioMedicine. 2:294-305. [PM:26086035].
  114. Kim, H. K., Chen, W., and Andreazza, A. C. (2015) The Potential Role of the NLRP3 Inflammasome as a Link between Mitochondrial Complex I Dysfunction and Inflammation in Bipolar Disorder. Neural Plast. 2015:408136- [PM:26075098].
  115. Singh, L., Saini, N., Bakhshi, S., Pushker, N., Sen, S., Sharma, A., Kaur, J., and Kashyap, S. (2015) Prognostic significance of mitochondrial oxidative phosphorylation complexes: Therapeutic target in the treatment of retinoblastoma. Mitochondrion. 23:55-63. [PM:26071002].
  116. Kim, H. W., Choi, W. S., Sorscher, N., Park, H. J., Tronche, F., Palmiter, R. D., and Xia, Z. (2015) Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiol. Aging [PM:26070241].
  117. Elguindy, M. M. and Nakamaru-Ogiso, E. (2015) Apoptosis Inducing Factor (AIF) and its Family Member, AMID, are Rotenone-Sensitive NADH:ubiquinone Oxidoreductases (NDH-2). J. Biol. Chem. [PM:26063804].
  118. Ortiz-Avila, O., Gallegos-Corona, M. A., Sanchez-Briones, L. A., Calderon-Cortes, E., Montoya-Perez, R., Rodriguez-Orozco, A. R., Campos-Garcia, J., Saavedra-Molina, A., Mejia-Zepeda, R., and Cortes-Rojo, C. (2015) Protective effects of dietary avocado oil on impaired electron transport chain function and exacerbated oxidative stress in liver mitochondria from diabetic rats. J. Bioenerg. Biomembr. [PM:26060181].
  119. Brass, E. P. and Hoppel, C. L. (2015) Mitochondria as targets of drug toxicity: Lessons from the R118 Phase 1 experience. Clin. Pharmacol. Ther. [PM:26059062].
  120. Yoritaka, A., Kawajiri, S., Yamamoto, Y., Nakahara, T., Ando, M., Hashimoto, K., Nagase, M., Saito, Y., and Hattori, N. (2015) Randomized, double-blind, placebo-controlled pilot trial of reduced coenzyme Q for Parkinson's disease. Parkinsonism. Relat Disord. [PM:26054881].
  121. Li, X., Zhang, W., Tang, J., Tan, L., Luo, X. J., Chen, X., and Yao, Y. G. (2015) Do nuclear-encoded core subunits of mitochondrial complex I confer genetic susceptibility to schizophrenia in Han Chinese populations? Sci. Rep. 5:11076- [PM:26053550].
  122. Rauthan, M., Ranji, P., Abukar, R., and Pilon, M. (2015) A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response, and Prolongs Lifespan via ROS and CED-4. G3. (Bethesda. ) [PM:26038366].
  123. Yang, X. Y., He, K., Pan, C. S., Li, Q., Liu, Y. Y., Yan, L., Wei, X. H., Hu, B. H., Chang, X., Mao, X. W., Huang, D. D., Wang, L. J., Hu, S. W., Jiang, Y., Wang, G. C., Fan, J. Y., Fan, T. P., and Han, J. Y. (2015) 3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 alpha subunit 10 to ameliorate cardiac reperfusion injury. Sci. Rep. 5:10739- [PM:26030156].
  124. Cwerman-Thibault, H., Augustin, S., Lechauve, C., Ayache, J., Ellouze, S., Sahel, J. A., and Corral-Debrinski, M. (2015) Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss. Mol. Ther. Methods Clin. Dev. 2:15003- [PM:26029714].
  125. Leman, G., Gueguen, N., Desquiret-Dumas, V., Kane, M. S., Wettervald, C., Chupin, S., Chevrollier, A., Lebre, A. S., Bonnefont, J. P., Barth, M., Amati-Bonneau, P., Verny, C., Henrion, D., Bonneau, D., Reynier, P., and Procaccio, V. (2015) Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency. Int. J. Biochem. Cell Biol. [PM:26024641].
  126. Fassone, E., Duncan, A. J., Taanman, J. W., Pagnamenta, A. T., Sadowski, M. I., Holand, T., Qasim, W., Rutland, P., Calvo, S. E., Mootha, V. K., Bitner-Glindzicz, M., and Rahman, S. (2015) FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. Hum. Mol. Genet. [PM:26022995].
  127. Fang, H., Shi, H., Li, X., Sun, D., Li, F., Li, B., Ding, Y., Ma, Y., Liu, Y., Zhang, Y., Shen, L., Bai, Y., Yang, Y., and Lu, J. (2015) Exercise intolerance and developmental delay associated with a novel mitochondrial ND5 mutation. Sci. Rep. 5:10480- [PM:26014388].
  128. Ito, T., Murai, M., Morisaka, H., and Miyoshi, H. (2015) Identification of the Binding Position of Amilorides in the Quinone Binding Pocket of Mitochondrial Complex I. Biochemistry [PM:26009789].
  129. Stepanova, A., Valls, A., and Galkin, A. (2015) Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I. Biochim. Biophys. Acta [PM:26009015].
  130. Cameron, J. M., Mackay, N., Feigenbaum, A., Tarnopolsky, M., Blaser, S., Robinson, B. H., and Schulze, A. (2015) Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome. Eur. J. Paediatr. Neurol. [PM:26008862].
  131. Tuz, K., Mezic, K. G., Xu, T., Barquera, B., and Juarez, O. (2015) The kinetic reaction mechanism of the Vibrio cholerae sodium -dependent NADH Dehydrogenase. J. Biol. Chem. [PM:26004776].
  132. Zhang, X., Yu, S., Tu, Y., and Huang, W. (2015) Mitochondrial tRNA A15951G mutation may not be associated with Leber's Hereditary Optic Neuropathy. Mitochondrial. DNA1-3. [PM:26000946].
  133. Sazanov, L. A. (2015) A giant molecular proton pump: structure and mechanism of respiratory complex I. Nat. Rev. Mol. Cell Biol. 16:375-388. [PM:25991374].
  134. Korste, A., Wulfhorst, H., Ikegami, T., Nowaczyk, M. M., and Stoll, R. (2015) Solution structure of the NDH-1 complex subunit CupS from Thermosynechococcus elongatus. Biochim. Biophys. Acta [PM:25982357].
  135. Saeki, K., Watanabe, M., Tsuboi, M., Sugano, S., Yoshitake, R., Tanaka, Y., Ong, S. M., Saito, T., Matsumoto, K., Fujita, N., Nishimura, R., and Nakagawa, T. (2015) Anti-tumour effect of metformin in canine mammary gland tumour cells. Vet. J. [PM:25981932].
  136. Lim, S. C., Carey, K. T., and McKenzie, M. (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am. J. Cancer Res. 5:689-701. [PM:25973307].
  137. Ge, H., Zhao, M., Lee, S., and Xu, Z. (2015) Mitochondrial Src tyrosine kinase plays a role in the cardioprotective effect of ischemic preconditioning by modulating complex I activity and mitochondrial ROS generation. Free Radic. Res.1-16. [PM:25968938].
  138. Essa, M. M., Subash, S., Dhanalakshmi, C., Manivasagam, T., Al-Adawi, S., Guillemin, G. J., and Thenmozhi, A. J. (2015) Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson's Disease. Neurochem. Res. [PM:25944473].
  139. Yuan, Y., Wang, W., Li, H., Yu, Y., Tao, J., Huang, S., and Zeng, Z. (2015) Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma. BMC. Cancer 15:346- [PM:25934296].
  140. Shehata, B. M., Cundiff, C. A., Lee, K., Sabharwal, A., Lalwani, M. K., Davis, A. K., Agarwal, V., Sivasubbu, S., Iannucci, G. J., and Gibson, G. (2015) Exome sequencing of patients with histiocytoid cardiomyopathy reveals a de novo NDUFB11 mutation that plays a role in the pathogenesis of histiocytoid cardiomyopathy. Am. J. Med. Genet. A [PM:25921236].
  141. Soole, K. L. and Smith, C. A. (2015) Analysis of Type II NAD(P)H Dehydrogenases. Methods Mol. Biol. 1305:151-164. [PM:25910733].
  142. Tadayon, S., Sharifiyazdi, H., Moazeni, M., and Divar, M. R. (2015) Molecular Differentiation of Fasciola Species and Characterization of Genetic Diversity of F. gigantica Using NADH Dehydrogenase I (ND1) Gene in the Endemic Areas of Iran. Iran J. Parasitol. 10:9-18. [PM:25904941].
  143. Kmita, K., Wirth, C., Warnau, J., Guerrero-Castillo, S., Hunte, C., Hummer, G., Kaila, V. R., Zwicker, K., Brandt, U., and Zickermann, V. (2015) Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I. Proc. Natl. Acad. Sci. U. S. A [PM:25902503].
  144. Angebault, C., Charif, M., Guegen, N., Piro-Megy, C., de Camaret, B. M., Procaccio, V., Guichet, P. O., Hebrard, M., Manes, G., Leboucq, N., Rivier, F., Hamel, C. P., Lenaers, G., and Roubertie, A. (2015) Mutation in NDUFA13/GRIM19 leads to early onset hypotonia, dyskinesia and sensorial deficiencies, and mitochondrial complex I instability. Hum. Mol. Genet. [PM:25901006].
  145. Frick, K., Schulte, M., and Friedrich, T. (2015) Reactive Oxygen Species Production by Escherichia coli Respiratory Complex I. Biochemistry [PM:25897800].
  146. Thapa, S., Lalrohlui, F., Ghatak, S., Zohmingthanga, J., Lallawmzuali, D., Pautu, J. L., and Senthil, K. N. (2015) Mitochondrial complex I and V gene polymorphisms associated with breast cancer in mizo-mongloid population. Breast Cancer [PM:25896597].
  147. Vartak, R., Deng, J., Fang, H., and Bai, Y. (2015) Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly. Biochim. Biophys. Acta [PM:25887158].
  148. Evangelisti, C., de, B. D., Kurelac, I., Ceccarelli, C., Prokisch, H., Meitinger, T., Caria, P., Vanni, R., Romeo, G., Tallini, G., Gasparre, G., and Bonora, E. (2015) A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors. BMC. Cancer 15:157- [PM:25880213].
  149. Spero, M. A., Aylward, F. O., Currie, C. R., and Donohue, T. J. (2015) Phylogenomic Analysis and Predicted Physiological Role of the Proton-Translocating NADH:Quinone Oxidoreductase (Complex I) Across Bacteria. MBio. 6: [PM:25873378].
  150. Narayanan, M., Leung, S. A., Inaba, Y., Elguindy, M. M., and Nakamaru-Ogiso, E. (2015) Semiquinone intermediates are involved in the energy coupling mechanism of E. coli complex I. Biochim. Biophys. Acta [PM:25868873].
  151. Markevich, N. I. and Hoek, J. B. (2015) Computational modeling analysis of mitochondrial superoxide production under varying substrate conditions and upon inhibition of different segments of the electron transport chain. Biochim. Biophys. Acta 1847:656-679. [PM:25868872].
  152. Wu, J., Luo, X., and Yan, L. J. (2015) Two dimensional blue native/SDS-PAGE to identify mitochondrial complex I subunits modified by 4-hydroxynonenal (HNE). Front Physiol 6:98- [PM:25859224].
  153. Mayer, J., Reichart, G., Tokay, T., Lange, F., Baltrusch, S., Junghanss, C., Wolkenhauer, O., Jaster, R., Kunz, M., Tiedge, M., Ibrahim, S., Fuellen, G., and Kohling, R. (2015) Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants. PLoS. ONE. 10:e0123863- [PM:25853418].
  154. Vos, M., Verstreken, P., and Klein, C. (2015) Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction. Biochem. Soc. Trans. 43:275-279. [PM:25849929].
  155. Murai, M., Murakami, S., Ito, T., and Miyoshi, H. (2015) Amilorides Bind to the Quinone Binding Pocket of Bovine Mitochondrial Complex I. Biochemistry [PM:25849763].
  156. Parameshwaran, K., Irwin, M. H., Steliou, K., Suppiramaniam, V., and Pinkert, C. A. (2015) Antioxidant-mediated reversal of oxidative damage in mouse modeling of complex I inhibition. Drug Dev. Res. 76:72-81. [PM:25847731].
  157. Schauer, M., Kottek, T., Schonherr, M., Bhattacharya, A., Ibrahim, S. M., Hirose, M., Kohling, R., Fuellen, G., Schmitz, U., and Kunz, M. (2015) A mutation in the NADH-dehydrogenase subunit 2 suppresses fibroblast aging. Oncotarget. [PM:25839158].
  158. Chaudhuri, A. D., Kabaria, S., Choi, D. C., Mouradian, M. M., and Junn, E. (2015) MicroRNA-7 promotes glycolysis to protect against 1-methyl-4-phenylpyridinium-induced cell death. J. Biol. Chem. [PM:25814668].
  159. Lindsay, D. P., Camara, A. K., Stowe, D. F., Lubbe, R., and Aldakkak, M. (2015) Differential effects of buffer pH on Ca(2+)-induced ROS emission with inhibited mitochondrial complexes I and III. Front Physiol 6:58- [PM:25805998].
  160. She, X., Khamooshi, K., Gao, Y., Shen, Y., Lv, Y., Calderone, R., Fonzi, W., Liu, W., and Li, D. (2015) Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis. Cell Microbiol. [PM:25801605].
  161. Worth, A. J., Gillespie, K. P., Mesaros, C., Guo, L., Basu, S. S., Snyder, N. W., and Blair, I. A. (2015) Rotenone stereospecifically increases (S)-2-hydroxyglutarate in SH-SY5Y neuronal cells. Chem. Res. Toxicol. [PM:25800467].
  162. Felici, R., Lapucci, A., Cavone, L., Pratesi, S., Berlinguer-Palmini, R., and Chiarugi, A. (2015) Pharmacological NAD-boosting Strategies Improve Mitochondrial Homeostasis in Human Complex I-mutant Fibroblasts. Mol. Pharmacol. [PM:25788480].
  163. Han, B., Wang, T. D., Shen, S. M., Yu, Y., Mao, C., Yao, Z. J., and Wang, L. S. (2015) Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism. BMC. Cancer 15:1133- [PM:25784115].
  164. Zhang, H. H., Qin, G. J., Li, X. L., Zhang, Y. H., Du, P. J., Zhang, P. Y., Zhao, Y. Y., and Wu, J. (2015) SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II-V functions in individual subsarcolemmal and intermyofibrillar mitochondria. J. Physiol Biochem. [PM:25782776].
  165. Gomez, A., Gomez, J., Torres, M. L., Naudi, A., Mota-Martorell, N., Pamplona, R., and Barja, G. (2015) Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction. J. Bioenerg. Biomembr. [PM:25773352].
  166. van Rahden, V. A., Fernandez-Vizarra, E., Alawi, M., Brand, K., Fellmann, F., Horn, D., Zeviani, M., and Kutsche, K. (2015) Mutations in NDUFB11, Encoding a Complex I Component of the Mitochondrial Respiratory Chain, Cause Microphthalmia with Linear Skin Defects Syndrome. Am. J. Hum. Genet. [PM:25772934].
  167. Lemire, B. D. (2015) A structural model for FOXRED1, an FAD-dependent oxidoreductase necessary for NADH: Ubiquinone oxidoreductase (complex I) assembly. Mitochondrion. 22:9-16. [PM:25765152].
  168. Patsi, J., Kervinen, M., Kytovuori, L., Majamaa, K., and Hassinen, I. E. (2015) Effects of pathogenic mutations in membrane subunits of mitochondrial Complex I on redox activity and proton translocation studied by modeling in Escherichia coli. Mitochondrion. 22:23-30. [PM:25747201].
  169. McCormack, S., Polyak, E., Ostrovsky, J., Dingley, S. D., Rao, M., Kwon, Y. J., Xiao, R., Zhang, Z., Nakamaru-Ogiso, E., and Falk, M. J. (2015) Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans. Mitochondrion. 22:45-59. [PM:25744875].
  170. Borshchevskiy, V., Round, E., Bertsova, Y., Polovinkin, V., Gushchin, I., Ishchenko, A., Kovalev, K., Mishin, A., Kachalova, G., Popov, A., Bogachev, A., and Gordeliy, V. (2015) Structural and Functional Investigation of Flavin Binding Center of the NqrC Subunit of Sodium-Translocating NADH:Quinone Oxidoreductase from Vibrio harveyi. PLoS. ONE. 10:e0118548- [PM:25734798].
  171. Murai, M., Habu, S., Murakami, S., Ito, T., and Miyoshi, H. (2015) Production of new amilorides as potent inhibitors of mitochondrial respiratory complex I. Biosci. Biotechnol. Biochem.1-6. [PM:25731956].
  172. Fan, X., Zhang, J., Li, W., and Peng, L. (2015) The NdhV subunit is required to stabilize the chloroplast NADH dehydrogenase-like complex in Arabidopsis. Plant J. [PM:25728844].
  173. Schiff, M., Haberberger, B., Xia, C., Mohsen, A. W., Goetzman, E. S., Wang, Y., Uppala, R., Zhang, Y., Karunanidhi, A., Prabhu, D., Alharbi, H., Prochownik, E. V., Haack, T., Haberle, J., Munnich, A., Rotig, A., Taylor, R. W., Nicholls, R. D., Kim, J. J., Prokisch, H., and Vockley, J. (2015) Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency. Hum. Mol. Genet. [PM:25721401].
  174. Matsuzaki, S. and Humphries, K. M. (2015) Selective inhibition of deactivated mitochondrial complex I by biguanides. Biochemistry [PM:25719498].
  175. Wang, P., Song, M., Zeng, Z. L., Zhu, C. F., Lu, W. H., Yang, J., Ma, M. Z., Huang, A. M., Hu, Y., and Huang, P. (2015) Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach. Oncotarget. [PM:25714130].
  176. Monti, C., Bondi, H., Urbani, A., Fasano, M., and Alberio, T. (2015) Systems biology analysis of the proteomic alterations induced by MPP(+), a Parkinson's disease-related mitochondrial toxin. Front Cell Neurosci. 9:14- [PM:25698928].
  177. Kammouni, W., Wood, H., Saleh, A., Appolinario, C. M., Fernyhough, P., and Jackson, A. C. (2015) Rabies virus phosphoprotein interacts with mitochondrial Complex I and induces mitochondrial dysfunction and oxidative stress. J. Neurovirol. [PM:25698500].
  178. Roy, S., Mondal, P., Sengupta, P. S., Dhak, D., Santra, R. C., Das, S., and Guin, P. S. (2015) Spectroscopic, computational and electrochemical studies on the formation of the copper complex of 1-amino-4-hydroxy-9,10-anthraquinone and effect of it on superoxide formation by NADH dehydrogenase. Dalton Trans. [PM:25691434].
  179. Alam, M. T., Manjeri, G. R., Rodenburg, R. J., Smeitink, J. A., Notebaart, R. A., Huynen, M., Willems, P. H., and Koopman, W. J. (2015) Skeletal muscle mitochondria of NDUFS4 mice display normal maximal pyruvate oxidation and ATP production. Biochim. Biophys. Acta [PM:25687896].
  180. Lemire, B. D. (2015) Evolution of FOXRED1, an FAD-dependent oxidoreductase necessary for NADH:ubiquinone oxidoreductase (Complex I) assembly. Biochim. Biophys. Acta 1847:451-457. [PM:25681241].
  181. Brecht, M., Richardson, M., Taranath, A., Grist, S., Thorburn, D., and Bratkovic, D. (2015) Leigh Syndrome Caused by the MT-ND5 m.13513G>A Mutation: A Case Presenting with WPW-Like Conduction Defect, Cardiomyopathy, Hypertension and Hyponatraemia. JIMD. Rep. [PM:25681084].
  182. Formosa, L. E., Mimaki, M., Frazier, A. E., McKenzie, M., Stait, T. L., Thorburn, D. R., Stroud, D. A., and Ryan, M. T. (2015) Characterization of mitochondrial FOXRED1 in the assembly of respiratory chain complex I. Hum. Mol. Genet. [PM:25678554].
  183. Xu, Q., Biener-Ramanujan, E., Yang, W., and Ramanujan, V. K. (2015) Targeting metabolic plasticity in breast cancer cells via mitochondrial complex I modulation. Breast Cancer Res. Treat. 150:43-56. [PM:25677747].
  184. Vatrinet, R., Iommarini, L., Kurelac, I., De, L. M., Gasparre, G., and Porcelli, A. M. (2015) Mitochondria: Targeting respiratory complex I to prevent the Warburg effect. Int. J. Biochem. Cell Biol. [PM:25668477].
  185. Barros-Minones, L., Goni-Allo, B., Suquia, V., Beitia, G., Aguirre, N., and Puerta, E. (2015) Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice. Neuropharmacology 93C:124-133. [PM:25666033].
  186. Ohtawa, M., Matsunaga, M., Fukunaga, K., Shimizu, R., Shimizu, E., Arima, S., Ohmori, J., Kita, K., Shiomi, K., Omura, S., and Nagamitsu, T. (2015) Design, synthesis, and biological evaluation of air-stable nafuredin-gamma analogs as complex I inhibitors. Bioorg. Med. Chem. 23:932-943. [PM:25659618].
  187. Yu, A. K., Song, L., Murray, K. D., van der List, D., Sun, C., Shen, Y., Xia, Z., and Cortopassi, G. A. (2015) Mitochondrial complex I deficiency leads to inflammation and retinal ganglion cell death in the Ndufs4 mouse. Hum. Mol. Genet. [PM:25652399].
  188. Goldstein, D. S., Sullivan, P., Cooney, A., Jinsmaa, Y., Kopin, I. J., and Sharabi, Y. (2015) Rotenone Decreases Intracellular Aldehyde Dehydrogenase Activity: Implications for the Pathogenesis of Parkinson Disease. J. Neurochem. [PM:25645689].
  189. Sinha, P. K., Castro-Guerrero, N., Patki, G., Sato, M., Torres-Bacete, J., Sinha, S., Miyoshi, H., Matsuno-Yagi, A., and Yagi, T. (2015) Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I). Biochemistry 54:753-764. [PM:25545070].
  190. Gorman, G. S., Blakely, E. L., Hornig-Do, H. T., Tuppen, H. A., Greaves, L. C., He, L., Baker, A., Falkous, G., Newman, J., Trenell, M. I., Lecky, B., Petty, R. K., Turnbull, D. M., McFarland, R., and Taylor, R. W. (2015) Novel MTND1 mutations cause isolated exercise intolerance, complex I deficiency and increased assembly factor expression. Clin. Sci. (Lond) [PM:25626417].
  191. Imaizumi, N., Kwang, L. K., Zhang, C., and Boelsterli, U. A. (2015) Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I. Redox. Biol. 4C:279-288. [PM:25625582].
  192. Michelini, L. G., Benevento, C. E., Rossato, F. A., Siqueira-Santos, E. S., and Castilho, R. F. (2015) Erratum to: Effects of Partial Inhibition of Respiratory Complex I on HO Production by Isolated Brain Mitochondria in Different Respiratory States. Neurochem. Res. [PM:25617162].
  193. Taketa, M., Nakagawa, H., Habukawa, M., Osuka, H., Kihira, K., Komori, H., Shibata, N., Ishii, M., Igarashi, Y., Nishihara, H., Yoon, K. S., Ogo, S., Shomura, Y., and Higuchi, Y. (2015) Crystallization and preliminary X-ray analysis of the NAD+-reducing [NiFe] hydrogenase from Hydrogenophilus thermoluteolus TH-1. Acta Crystallogr. F. Struct. Biol. Commun. 71:96-99. [PM:25615977].
  194. Bjorkman, K., Sofou, K., Darin, N., Holme, E., Kollberg, G., Cayuela, J. A., Dahle, K. M., Oldfors, A., Moslemi, A. R., and Tulinius, M. (2015) Broad phenotypic variability in patients with complex I deficiency due to mutations in NDUFS1 and NDUFV1. Mitochondrion. [PM:25615419].
  195. Talla, V., Koilkonda, R. D., Porciatti, V., Chiodo, V. A., Boye, S. L., Hauswirth, W. W., and Guy, J. (2015) Complex I Subunit Gene Therapy with NDUFA6 Ameliorates Neurodegeneration in EAE. Invest Ophthalmol. Vis. Sci. [PM:25613946].
  196. de, V. S., Dorner, K., Strampraad, M. J., and Friedrich, T. (2015) Electron Tunneling Rates in Respiratory Complex I Are Tuned for Efficient Energy Conversion. Angew. Chem. Int. Ed Engl. [PM:25600069].
  197. Michelini, L. G., Figueira, T. R., Siqueira-Santos, E. S., and Castilho, R. F. (2015) Rotenone exerts similar stimulatory effects on HO production by isolated brain mitochondria from young-adult and old rats. Neurosci. Lett. 589C:25-30. [PM:25596437].
  198. Skemiene, K., Liobikas, J., and Borutaite, V. (2015) Anthocyanins as substrates for mitochondrial complex I: protective effect against heart ischemic injury. FEBS J. [PM:25586661].
  199. Reddy, G. K., Lindner, S. N., and Wendisch, V. F. (2015) Metabolic Engineering an ATP-neutral EMP pathway in Corynebacterium glutamicum: adaptive point mutation in NADH dehydrogenase restores growth. Appl. Environ. Microbiol. [PM:25576602].
  200. Zickermann, V., Wirth, C., Nasiri, H., Siegmund, K., Schwalbe, H., Hunte, C., and Brandt, U. (2015) Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I. Science 347:44-49. [PM:25554780].
  201. Wrangel, C., Schwabe, K., John, N., Krauss, J. K., and Alam, M. (2015) The rotenone-induced rat model of Parkinson's disease: Behavioral and electrophysiological findings. Behav. Brain Res. 279:52-61. [PM:25446762].
  202. Song, L. and Cortopassi, G. (2015) Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. 1594:82-91. [PM:25446449].

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