Publications (2014)

  1. Kong, D., Zhao, L., Du, Y., He, P., Zou, Y., Yang, L., Sun, L., Wang, H., Xu, D., Meng, X., and Sun, X. (2014) Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth. Int. J. Clin. Exp. Pathol. 7:7497-7507. [PM:25550785].
  2. Rybalka, E., Timpani, C. A., Cooke, M. B., Williams, A. D., and Hayes, A. (2014) Defects in mitochondrial ATP synthesis in dystrophin-deficient mdx skeletal muscles may be caused by complex I insufficiency. PLoS. ONE. 9:e115763- [PM:25541951].
  3. Becker, L., Kling, E., Schiller, E., Zeh, R., Schrewe, A., Holter, S. M., Mossbrugger, I., Calzada-Wack, J., Strecker, V., Wittig, I., Dumitru, I., Wenz, T., Bender, A., Aichler, M., Janik, D., Neff, F., Walch, A., Quintanilla-Fend, L., Floss, T., Bekeredjian, R., Gailus-Durner, V., Fuchs, H., Wurst, W., Meitinger, T., Prokisch, H., de Angelis, M. H., and Klopstock, T. (2014) MTO1-Deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy. PLoS. ONE. 9:e114918- [PM:25506927].
  4. Shea, M. E., Mezic, K. G., Juarez, O., and Barquera, B. (2014) A Mutation in Na-NQR Uncouples Electron Flow from Na Translocation in the Presence of K. Biochemistry [PM:25486106].
  5. Prajapati, P., Sripada, L., Singh, K., Bhatelia, K., Singh, R., and Singh, R. (2014) TNF-alpha regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells. Biochim. Biophys. Acta 1852:451-461. [PM:25481834].
  6. Steuber, J., Vohl, G., Casutt, M. S., Vorburger, T., Diederichs, K., and Fritz, G. (2014) Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase. Nature 516:62-67. [PM:25471880].
  7. Luo, Z., Zeng, W., Tang, W., Long, T., Zhang, J., Xie, X., Kuang, Y., Chen, M., Su, J., and Chen, X. (2014) CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant Melanoma Cells. Curr. Mol. Med. 14:1252-1264. [PM:25470292].
  8. Bongard, R. D., Townsley, M. I., and Merker, M. P. (2014) The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q (CoQ). Free Radic. Biol. Med. 79C:69-77. [PM:25452141].
  9. Diaz-Vasquez, W. A., Abarca-Lagunas, M. J., Cornejo, F. A., Pinto, C. A., Arenas, F. A., and Vasquez, C. C. (2014) Tellurite-mediated damage to the Escherichia coli NDH-dehydrogenases and terminal oxidases in aerobic conditions. Arch. Biochem. Biophys. [PM:25447814].
  10. Marreiros, B. C., Batista, A. P., and Pereira, M. M. (2014) Respiratory complex I from Escherichia coli does not transport Na in the absence of its NuoL subunit. FEBS Lett. 588:4520-4525. [PM:25447539].
  11. Maturana, M. G., Pinheiro, A. S., Souza, T. L., and Follmer, C. (2014) Unveiling the role of the pesticides paraquat and rotenone on alpha-synuclein fibrillation in vitro. Neurotoxicology 46C:35-43. [PM:25447323].
  12. Kang, P. T., Chen, C., and Chen, Y. (2014) Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS. Free Radic. Biol. Med. 79C:56-68. [PM:25445401].
  13. Hollerhage, M., Deck, R., De, A. A., Respondek, G., Xu, H., Rosler, T. W., Salama, M., Carlsson, T., Yamada, E. S., Gad El Hak, S. A., Goedert, M., Oertel, W. H., and Hoglinger, G. U. (2014) Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice. PLoS. ONE. 9:e113557- [PM:25437199].
  14. Yang, M., Stowe, D. F., Udoh, K. B., Heisner, J. S., and Camara, A. K. (2014) Reversible Blockade of Complex I or Inhibition of PKCbeta Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia. PLoS. ONE. 9:e113534- [PM:25436907].
  15. Goswami, P., Gupta, S., Biswas, J., Joshi, N., Swarnkar, S., Nath, C., and Singh, S. (2014) Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons. Mol. Neurobiol. [PM:25428620].
  16. Masuya, T., Murai, M., Morisaka, H., and Miyoshi, H. (2014) Pinpoint Chemical Modification of Asp160 in the 49 kDa Subunit of Bovine Mitochondrial Complex I via a Combination of Ligand-Directed Tosyl Chemistry and Click Chemistry. Biochemistry [PM:25419630].
  17. Keogh, M. J., Daud, D., Pyle, A., Duff, J., Griffin, H., He, L., Alston, C. L., Steele, H., Taggart, S., Basu, A. P., Taylor, R. W., Horvath, R., Ramesh, V., and Chinnery, P. F. (2014) A novel de novo STXBP1 mutation is associated with mitochondrial complex I deficiency and late-onset juvenile-onset parkinsonism. Neurogenetics. [PM:25418441].
  18. Tsukada, H. (2014) The Use of (18)F-BCPP-EF as a PET Probe for Complex I Activity in the Brain. Methods Enzymol. 547:417-431. [PM:25416368].
  19. Pogson, J. H., Ivatt, R. M., Sanchez-Martinez, A., Tufi, R., Wilson, E., Mortiboys, H., and Whitworth, A. J. (2014) The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy. PLoS. Genet. 10:e1004815- [PM:25412178].
  20. De, R. D., Signorile, A., Santeramo, A., Larizza, M., Lattanzio, P., Capitanio, G., and Papa, S. (2014) Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain. Biochim. Biophys. Acta 1853:183-191. [PM:25409931].
  21. Finsterer, J. and Zarrouk-Mahjoub, S. (2014) Implications of non-compaction in association with respiratory chain complex-I deficiency. Cardiol. Young.1-2. [PM:25403618].
  22. Bruch, J., Xu, H., De, A. A., and Hoglinger, G. (2014) Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation. PLoS. ONE. 9:e113070- [PM:25402454].
  23. Hsu, Y. W., Wang, H. J., Hsieh, M. H., Hsieh, H. L., and Jauh, G. Y. (2014) Arabidopsis mTERF15 Is Required for Mitochondrial nad2 Intron 3 Splicing and Functional Complex I Activity. PLoS. ONE. 9:e112360- [PM:25402171].
  24. Chen, Z., Zhao, Z., Ye, Q., Chen, Y., Pan, X., Sun, B., Huang, H., and Zheng, A. (2014) Mild clinical manifestation and unusual recovery upon coenzyme Q10 treatment in the first Chinese Leigh syndrome pedigree with mutation m.10197 G>A. Mol. Med. Rep. [PM:25384404].
  25. Chang, E., Liu, H., Unterschemmann, K., Ellinghaus, P., Liu, S., Gekeler, V., Cheng, Z., Berndorff, D., and Gambhir, S. S. (2014) 18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243. Clin. Cancer Res. [PM:25381339].
  26. Ullmann, E., Tan, T. C., Gundinger, T., Herwig, C., Divne, C., and Spadiut, O. (2014) A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis. Biosci. Rep. [PM:25372605].
  27. Ramos, A. R., Grein, F., Oliveira, G. P., Venceslau, S. S., Keller, K. L., Wall, J. D., and Pereira, I. A. (2014) The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough. Environ. Microbiol. [PM:25367508].
  28. Djoko, K. Y., Donnelly, P. S., and McEwan, A. G. (2014) Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes. Metallomics. 6:2250-2259. [PM:25366244].
  29. Gielisch, I. and Meierhofer, D. (2014) Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone. J. Proteome. Res. [PM:25361611].
  30. Zhu, Y., Wang, Z., Ni, J., Zhang, Y., Chen, M., Cai, J., Li, X., Zhang, W., and Zhang, C. (2014) Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese. J. Hum. Genet. [PM:25354934].
  31. Luengo, A., Sullivan, L. B., and Heiden, M. G. (2014) Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC. Biol. 12:82- [PM:25347702].
  32. Gueven, N. and Faldu, D. (2013) Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable. Rare. Dis. Res. 2:130-135. [PM:25343117].
  33. Chu, M. J., Hickey, A. J., Jiang, Y., Petzer, A., Bartlett, A. S., and Phillips, A. R. (2014) Mitochondrial dysfunction in rat steatotic liver is due to a defect in Complex-I making them more susceptible to prolonged cold ischemia. Liver Transpl. [PM:25312517].
  34. Bird, M. J., Wijeyeratne, X. W., Komen, J. C., Laskowski, A., Ryan, M. T., Thorburn, D. R., and Frazier, A. E. (2014) Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse. Biosci. Rep. [PM:25312000].
  35. Zhou, Q., Liu, C., Liu, W., Zhang, H., Zhang, R., Liu, J., Zhang, J., Xu, C., Liu, L., Huang, S., and Chen, L. (2014) Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis. Toxicol. Sci. [PM:25304210].
  36. Fontaine, E. (2014) Metformin and respiratory chain complex I: the last piece of the puzzle? Biochem. J. 463:e3-e5. [PM:25301073].
  37. Michelini, L. G., Benevento, C. E., Rossato, F. A., Siqueira-Santos, E. S., and Castilho, R. F. (2014) Effects of Partial Inhibition of Respiratory Complex I on HO Production by Isolated Brain Mitochondria in Different Respiratory States. Neurochem. Res. [PM:25287903].
  38. Belevich, N., Belevich, G., and Verkhovskaya, M. (2014) Real-time optical studies of respiratory Complex I turnover. Biochim. Biophys. Acta 1837:1973-1980. [PM:25283488].
  39. Choi, W. S. and Xia, Z. (2014) Maneb-induced dopaminergic neuronal death is not affected by loss of mitochondrial complex I activity: results from primary mesencephalic dopaminergic neurons cultured from individual Ndufs4+/+ and Ndufs4-/- mouse embryos. Neuroreport 25:1350-1355. [PM:25275677].
  40. Kostner, D., Luchterhand, B., Junker, A., Volland, S., Daniel, R., Buchs, J., Liebl, W., and Ehrenreich, A. (2014) The consequence of an additional NADH dehydrogenase paralog on the growth of Gluconobacter oxydans DSM3504. Appl. Microbiol. Biotechnol. [PM:25267158].
  41. Nascimento, C., Kim, H. K., Young, L. T., Mendonca, K. M., Grinberg, L. T., Lafer, B., and Andreazza, A. C. (2014) Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J. Neural Transm. [PM:25261015].
  42. Li, L., Dong, X., Shu, B., Wang, Z., Hu, Q., and Zhong, G. (2014) Iron-sulfur protein in mitochondrial complexes of Spodoptera litura as potential site for ROS generation. J. Insect Physiol [PM:25257538].
  43. Gershoni, M., Levin, L., Ovadia, O., Toiw, Y., Shani, N., Dadon, S., Barzilai, N., Bergman, A., Atzmon, G., Wainstein, J., Tsur, A., Nijtmans, L., Glaser, B., and Mishmar, D. (2014) Disrupting mitochondrial-nuclear co-evolution affects OXPHOS complex I integrity and impacts human health. Genome Biol. Evol. [PM:25245408].
  44. Schulte, M., Mattay, D., Kriegel, S., Hellwig, P., and Friedrich, T. (2014) Inhibition of the Escherichia coli respiratory complex I by Zn2+. Biochemistry [PM:25238255].
  45. Sanders, L. H., Howlett, E. H., McCoy, J., and Greenamyre, J. T. (2014) Mitochondrial DNA Damage as a Peripheral Biomarker for Mitochondrial Toxin Exposure in Rats. Toxicol. Sci. [PM:25237061].
  46. Bazil, J. N., Pannala, V. R., Dash, R. K., and Beard, D. A. (2014) Determining the Origins of Superoxide and Hydrogen Peroxide in the Mammalian NADH:Ubiquinone Oxidoreductase. Free Radic. Biol. Med. [PM:25236739].
  47. Kriegel, S., Uchida, T., Osawa, M., Friedrich, T., and Hellwig, P. (2014) A biomimetic environment to study E. coli Complex I through Surface Enhanced IR Absorption Spectroscopy (SEIRAS). Biochemistry [PM:25225967].
  48. Scheffler, I. E. (2014) Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. J. Inherit. Metab Dis. [PM:25224827].
  49. McKenzie, M., Chiotis, M., Hroudova, J., Sanchez, M. I., Lim, S. C., Cook, M. J., McKelvie, P., Cotton, R. G., Murphy, M., John, J. C., and Trounce, I. A. (2014) Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain. Hum. Mutat. [PM:25219341].
  50. Sing, A., Tsatskis, Y., Fabian, L., Hester, I., Rosenfeld, R., Serricchio, M., Yau, N., Bietenhader, M., Shanbhag, R., Jurisicova, A., Brill, J. A., McQuibban, G. A., and McNeill, H. (2014) The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Cell 158:1293-1308. [PM:25215488].
  51. Vinothkumar, K. R., Zhu, J., and Hirst, J. (2014) Architecture of mammalian respiratory complex I. Nature [PM:25209663].
  52. Salama, M., El-Morsy, D., El-Gamal, M., Shabka, O., and Mohamed, W. M. (2014) Mitochondrial complex I inhibition as a possible mechanism of chlorpyrifos induced neurotoxicity. Ann. Neurosci. 21:85-89. [PM:25206071].
  53. Steuber, J., Halang, P., Vorburger, T., Steffen, W., Vohl, G., and Fritz, G. (2014) Central role of the Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) in sodium bioenergetics of Vibrio cholerae. Biol. Chem. [PM:25205724].
  54. Zhang, J., Jiang, P., Jin, X., Liu, X., Zhang, M., Xie, S., Gao, M., Zhang, S., Sun, Y. H., Zhu, J., Ji, Y., Wei, Q. P., Tong, Y., and Guan, M. X. (2014) Leber's hereditary optic neuropathy caused by the homoplasmic ND1 m.3635G>A mutation in nine Han Chinese families. Mitochondrion. 18C:18-26. [PM:25194554].
  55. Gonzalez-Siso, M. I., Tourino, A., Vizoso, A., Pereira-Rodriguez, A., Rodriguez-Belmonte, E., Becerra, M., and Cerdan, M. E. (2014) Improved bioethanol production in an engineered Kluyveromyces lactis strain shifted from respiratory to fermentative metabolism by deletion of NDI1. Microb. Biotechnol. [PM:25186243].
  56. Jiang, Z., Yu, J., Xia, B., and Zhuo, G. (2014) Mitochondrial tRNA 15891C>G mutation was not associated with Leber's hereditary optic neuropathy in Han Chinese patients. Mitochondrial. DNA1-3. [PM:25186221].
  57. Miao, Y. J., Xu, X. F., Xu, F., Chen, Y., Chen, J. W., and Li, X. (2014) The structure-activity relationships of mono-THF ACGs on mitochondrial complex I with a molecular modelling study. Nat. Prod. Res. 28:1929-1935. [PM:25183444].
  58. Ashmore, T., Fernandez, B. O., Branco-Price, C., West, J. A., Cowburn, A. S., Heather, L. C., Griffin, J. L., Johnson, R. S., Feelisch, M., and Murray, A. J. (2014) Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. J. Physiol [PM:25172947].
  59. Poursadegh, Z. A., Ghorbian, S., Abkar, M., Poursadegh Zonouzi, A. A., and Azadi, A. (2014) Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis. J. Neurol. Sci. [PM:25172194].
  60. Abdin, A. and Sarhan, N. (2014) Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity. Can. J. Physiol Pharmacol.1-9. [PM:25162205].
  61. McDowall, J. S., Murphy, B. J., Haumann, M., Palmer, T., Armstrong, F. A., and Sargent, F. (2014) Bacterial formate hydrogenlyase complex. Proc. Natl. Acad. Sci. U. S. A [PM:25157147].
  62. La, M. C., Carbonelli, M., Barboni, P., Sadun, A. A., and Carelli, V. (2014) Medical management of hereditary optic neuropathies. Front Neurol. 5:141- [PM:25132831].
  63. Jin, Z., Wei, W., Yang, M., Du, Y., and Wan, Y. (2014) Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization. Cell Metab [PM:25130399].
  64. Awasthy, D., Ambady, A., Narayana, A., Morayya, S., and Sharma, U. (2014) Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro. Gene 550:110-116. [PM:25128581].
  65. Gospodaryov, D. V., Lushchak, O. V., Rovenko, B. M., Perkhulyn, N. V., Gerards, M., Tuomela, T., and Jacobs, H. T. (2014) Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim. Biophys. Acta 1837:1861-1869. [PM:25124484].
  66. Worth, A. J., Basu, S. S., Snyder, N. W., Mesaros, C., and Blair, I. A. (2014) Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid beta-oxidation supporting acetyl-coenzyme A levels. J. Biol. Chem. [PM:25122772].
  67. Wulfhorst, H., Franken, L. E., Wessinghage, T., Boekema, E. J., and Nowaczyk, M. M. (2014) The 5 kDa Protein NdhP Is Essential for Stable NDH-1L Assembly in Thermosynechococcus elongatus. PLoS. ONE. 9:e103584- [PM:25119998].
  68. Tapia, E., Sanchez-Lozada, L. G., Garcia-Nino, W. R., Garcia, E., Cerecedo, A., Garcia-Arroyo, F. E., Osorio, H., Arellano, A., Cristobal-Garcia, M., Loredo, M. L., Molina-Jijon, E., Hernandez-Damian, J., Negrette-Guzman, M., Zazueta, C., Huerta-Yepez, S., Reyes, J. L., Madero, M., and Pedraza-Chaverri, J. (2014) Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Free Radic. Res.1-36. [PM:25119790].
  69. Radad, K., Scheller, D., Rausch, W. D., Reichmann, H., and Gille, G. (2014) Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 52:179-186. [PM:25118903].
  70. Miller, D. K., Menezes, M. J., Simons, C., Riley, L. G., Cooper, S. T., Grimmond, S. M., Thorburn, D. R., Christodoulou, J., and Taft, R. J. (2014) Rapid Identification of a Novel Complex I MT-ND3 m.10134C>A Mutation in a Leigh Syndrome Patient. PLoS. ONE. 9:e104879- [PM:25118196].
  71. Kim, E. M., Park, J. K., Hwang, S. G., Kim, W. J., Liu, Z. G., Kang, S. W., and Um, H. D. (2014) Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins. Oncotarget. [PM:25115399].
  72. Solotoff, V., Moseler, R., and Schulte, U. (2014) Two pentatricopeptide repeat domain proteins are required for the synthesis of respiratory complex I. Curr. Genet. [PM:25108509].
  73. Li, H., Chen, G., Ma, W., and Li, P. A. (2014) Water-soluble coenzyme q10 inhibits nuclear translocation of apoptosis inducing factor and cell death caused by mitochondrial complex I inhibition. Int. J. Mol. Sci. 15:13388-13400. [PM:25089873].
  74. Burman, J. L., Itsara, L. S., Kayser, E. B., Suthammarak, W., Wang, A. M., Kaeberlein, M., Sedensky, M. M., Morgan, P. G., and Pallanck, L. J. (2014) A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis. Model. Mech. [PM:25085991].
  75. Han, G., Casson, R., Chidlow, G., and Wood, J. P. (2014) The Mitochondrial Complex I Inhibitor Rotenone Induces Endoplasmic Reticulum Stress and Activation of GSK3beta in Cultured Rat Retinal Cells. Invest Ophthalmol. Vis. Sci. [PM:25082888].
  76. Giordano, S., Dodson, M., Ravi, S., Redmann, M., Ouyang, X., Darley Usmar, V. M., and Zhang, J. (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J. Neurochem. [PM:25081478].
  77. Jovanovic, D. S., Dordevic, M., Savkovic, U., and Lazarevic, J. (2014) The effect of mitochondrial complex I inhibitor on longevity of short-lived and long-lived seed beetles and its mitonuclear hybrids. Biogerontology. 15:487-501. [PM:25078074].
  78. Nakamaru-Ogiso, E., Narayanan, M., and Sakyiama, J. A. (2014) Roles of semiquinone species in proton pumping mechanism by complex I. J. Bioenerg. Biomembr. [PM:25077450].
  79. Heiske, M., Nazaret, C., and Mazat, J. P. (2014) Modeling the respiratory chain complexes with biothermokinetic equati. Biochim. Biophys. Acta [PM:25064016].
  80. Tan, P., Feng, Z., Zhang, L., Hou, T., and Li, Y. (2014) The mechanism of proton translocation in respiratory complex I from molecular dynamics. J. Recept. Signal. Transduct. Res.1-10. [PM:25055024].
  81. Barquera, B. (2014) The sodium pumping NADH:quinone oxidoreductase (Na-NQR), a unique redox-driven ion pump. J. Bioenerg. Biomembr. [PM:25052842].
  82. Kokaze, A., Yoshida, M., Ishikawa, M., Matsunaga, N., Karita, K., Ohtsu, T., Ochiai, H., Shirasawa, T., Nanri, H., Baba, Y., Hoshino, H., and Takashima, Y. (2014) NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study. Tob. Induc. Dis. 12:11- [PM:25031572].
  83. Vartak, R. S., Semwal, M. K., and Bai, Y. (2014) An update on complex I assembly: the assembly of players. J. Bioenerg. Biomembr. [PM:25030182].
  84. Friedrich, T. (2014) On the mechanism of respiratory complex I. J. Bioenerg. Biomembr. [PM:25022766].
  85. Strickland, M., Juarez, O., Neehaul, Y., Cook, D. A., Barquera, B., and Hellwig, P. (2014) The Conformational Changes Induced by Ubiquinone Binding in the Na+-pumping NADH:ubiquinone Oxidoreductase (NQR) are Kinetically Controlled by Conserved Glycines 140 and 141 of the NqrB Subunit. J. Biol. Chem. [PM:25006248].
  86. Pepe, S., Mentzer, R. M., Jr., and Gottlieb, R. A. (2014) Cell-permeable protein therapy for complex I dysfunction. J. Bioenerg. Biomembr. [PM:25005682].
  87. Vohl, G., Nedielkov, R., Claussen, B., Casutt, M. S., Vorburger, T., Diederichs, K., Moller, H. M., Steuber, J., and Fritz, G. (2014) Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na(+)-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Crystallogr. F. Struct. Biol. Commun. 70:987-992. [PM:25005105].
  88. Murai, M. and Miyoshi, H. (2014) Chemical modifications of respiratory complex I for structural and functional studies. J. Bioenerg. Biomembr. [PM:24993592].
  89. Gutierrez-Sanz, O., Olea, D., Pita, M., Batista, A. P., Alonso, A., Pereira, M. M., Velez, M., and De Lacey, A. L. (2014) Reconstitution of respiratory complex I on a biomimetic membrane supported on gold electrodes. Langmuir 30:9007-9015. [PM:24988043].
  90. Yagi, T. and Matsuno-Yagi, A. (2014) Respiratory complex I: hop (structure), step (reaction mechanism) and jump (potential remedy). J. Bioenerg. Biomembr. [PM:24986732].
  91. Sato, M., Torres-Bacete, J., Sinha, P. K., Matsuno-Yagi, A., and Yagi, T. (2014) Essential regions in the membrane domain of bacterial complex I (NDH-1): the machinery for proton translocation. J. Bioenerg. Biomembr. [PM:24973951].
  92. Wu, L., Peng, J., Ma, Y., He, F., Deng, X., Wang, G., Lifen, Y., and Yin, F. (2014) Leukodystrophy associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFAF1 gene. Mitochondrial. DNA1-4. [PM:24963768].
  93. de Sousa, R. T., Streck, E. L., Zanetti, M. V., Ferreira, G. K., Diniz, B. S., Brunoni, A. R., Busatto, G. F., Gattaz, W. F., and Machado-Vieira, R. (2014) Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes. Psychopharmacology (Berl) [PM:24961563].
  94. Duarte, M. and Tomas, A. M. (2014) The mitochondrial complex I of trypanosomat. J. Bioenerg. Biomembr. [PM:24961227].
  95. Hur, J. H., Stork, D. A., and Walker, D. W. (2014) Complex-I-ty in aging. J. Bioenerg. Biomembr. [PM:24961226].
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  147. Jia, F., Song, N., Zhao, C., Xie, J., and Jiang, H. (2014) Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice. PLoS. ONE. 9:e91641- [PM:24618574].
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  164. Steinsiek, S., Stagge, S., and Bettenbrock, K. (2014) Analysis of Escherichia coli Mutants with a Linear Respiratory Chain. PLoS. ONE. 9:e87307- [PM:24475268].
  165. Tsukada, H., Nishiyama, S., Fukumoto, D., Kanazawa, M., and Harada, N. (2014) Novel PET Probes 18F-BCPP-EF and 18F-BCPP-BF for Mitochondrial Complex I: A PET Study in Comparison with 18F-BMS-747158-02 in Rat Brain. J. Nucl. Med. [PM:24470629].
  166. Davoudi, M., Kotarsky, H., Hansson, E., and Fellman, V. (2014) Complex I Function and Supercomplex Formation Are Preserved in Liver Mitochondria Despite Progressive Complex III Deficiency. PLoS. ONE. 9:e86767- [PM:24466228].
  167. Koilkonda, R. D., Yu, H., Chou, T. H., Feuer, W. J., Ruggeri, M., Porciatti, V., Tse, D., Hauswirth, W. W., Chiodo, V., Boye, S. L., Lewin, A. S., Neuringer, M., Renner, L., and Guy, J. (2014) Safety and Effects of the Vector for the Leber Hereditary Optic Neuropathy Gene Therapy Clinical Trial. JAMA Ophthalmol. [PM:24457989].
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  172. Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., Lott, J. S., Sazanov, L. A., and Cook, G. M. (2014) Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol. Microbiol. [PM:24444429].
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  174. Villegas, J. M., Valle, L., Moran Vieyra, F. E., Rintoul, M. R., Borsarelli, C. D., and Rapisarda, V. A. (2014) FAD binding properties of a cytosolic version of Escherichia coli NADH dehydrogenase-2. Biochim. Biophys. Acta 1844:576-584. [PM:24418395].
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  177. Stocks, P. A., Barton, V., Antoine, T., Biagini, G. A., Ward, S. A., and O'neill, P. M. (2014) Novel inhibitors of the Plasmodium falciparum electron transport chain. Parasitology 141:50-65. [PM:24401337].
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  179. Yamada, E. S., Respondek, G., Mussner, S., de, A. A., Hollerhage, M., Depienne, C., Rastetter, A., Tarze, A., Friguet, B., Salama, M., Champy, P., Oertel, W. H., and Hoglinger, G. U. (2014) Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp. Neurol. 253C:113-125. [PM:24389273].
  180. Hughes, S. D., Kanabus, M., Anderson, G., Hargreaves, I. P., Rutherford, T., Donnell, M. O., Cross, J. H., Rahman, S., Eaton, S., and Heales, S. J. (2014) The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells. J. Neurochem. [PM:24383952].
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