Publications (2014)

  1. Kong, D., Zhao, L., Du, Y., He, P., Zou, Y., Yang, L., Sun, L., Wang, H., Xu, D., Meng, X., and Sun, X. (2014) Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth. Int. J. Clin. Exp. Pathol. 7:7497-7507. [PM:25550785].
  2. Rybalka, E., Timpani, C. A., Cooke, M. B., Williams, A. D., and Hayes, A. (2014) Defects in mitochondrial ATP synthesis in dystrophin-deficient mdx skeletal muscles may be caused by complex I insufficiency. PLoS. ONE. 9:e115763- [PM:25541951].
  3. Becker, L., Kling, E., Schiller, E., Zeh, R., Schrewe, A., Holter, S. M., Mossbrugger, I., Calzada-Wack, J., Strecker, V., Wittig, I., Dumitru, I., Wenz, T., Bender, A., Aichler, M., Janik, D., Neff, F., Walch, A., Quintanilla-Fend, L., Floss, T., Bekeredjian, R., Gailus-Durner, V., Fuchs, H., Wurst, W., Meitinger, T., Prokisch, H., de Angelis, M. H., and Klopstock, T. (2014) MTO1-Deficient Mouse Model Mirrors the Human Phenotype Showing Complex I Defect and Cardiomyopathy. PLoS. ONE. 9:e114918- [PM:25506927].
  4. Shea, M. E., Mezic, K. G., Juarez, O., and Barquera, B. (2014) A Mutation in Na-NQR Uncouples Electron Flow from Na Translocation in the Presence of K. Biochemistry [PM:25486106].
  5. Prajapati, P., Sripada, L., Singh, K., Bhatelia, K., Singh, R., and Singh, R. (2014) TNF-alpha regulates miRNA targeting mitochondrial complex-I and induces cell death in dopaminergic cells. Biochim. Biophys. Acta 1852:451-461. [PM:25481834].
  6. Steuber, J., Vohl, G., Casutt, M. S., Vorburger, T., Diederichs, K., and Fritz, G. (2014) Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase. Nature 516:62-67. [PM:25471880].
  7. Luo, Z., Zeng, W., Tang, W., Long, T., Zhang, J., Xie, X., Kuang, Y., Chen, M., Su, J., and Chen, X. (2014) CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant Melanoma Cells. Curr. Mol. Med. 14:1252-1264. [PM:25470292].
  8. Bongard, R. D., Townsley, M. I., and Merker, M. P. (2014) The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q (CoQ). Free Radic. Biol. Med. 79C:69-77. [PM:25452141].
  9. Diaz-Vasquez, W. A., Abarca-Lagunas, M. J., Cornejo, F. A., Pinto, C. A., Arenas, F. A., and Vasquez, C. C. (2014) Tellurite-mediated damage to the Escherichia coli NDH-dehydrogenases and terminal oxidases in aerobic conditions. Arch. Biochem. Biophys. [PM:25447814].
  10. Marreiros, B. C., Batista, A. P., and Pereira, M. M. (2014) Respiratory complex I from Escherichia coli does not transport Na in the absence of its NuoL subunit. FEBS Lett. 588:4520-4525. [PM:25447539].
  11. Maturana, M. G., Pinheiro, A. S., Souza, T. L., and Follmer, C. (2014) Unveiling the role of the pesticides paraquat and rotenone on alpha-synuclein fibrillation in vitro. Neurotoxicology 46C:35-43. [PM:25447323].
  12. Kang, P. T., Chen, C., and Chen, Y. (2014) Increased mitochondrial prooxidant activity mediates up-regulation of Complex I S-glutathionylation via protein thiyl radical in the murine heart of eNOS. Free Radic. Biol. Med. 79C:56-68. [PM:25445401].
  13. Hollerhage, M., Deck, R., De, A. A., Respondek, G., Xu, H., Rosler, T. W., Salama, M., Carlsson, T., Yamada, E. S., Gad El Hak, S. A., Goedert, M., Oertel, W. H., and Hoglinger, G. U. (2014) Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice. PLoS. ONE. 9:e113557- [PM:25437199].
  14. Yang, M., Stowe, D. F., Udoh, K. B., Heisner, J. S., and Camara, A. K. (2014) Reversible Blockade of Complex I or Inhibition of PKCbeta Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia. PLoS. ONE. 9:e113534- [PM:25436907].
  15. Goswami, P., Gupta, S., Biswas, J., Joshi, N., Swarnkar, S., Nath, C., and Singh, S. (2014) Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons. Mol. Neurobiol. [PM:25428620].
  16. Masuya, T., Murai, M., Morisaka, H., and Miyoshi, H. (2014) Pinpoint Chemical Modification of Asp160 in the 49 kDa Subunit of Bovine Mitochondrial Complex I via a Combination of Ligand-Directed Tosyl Chemistry and Click Chemistry. Biochemistry [PM:25419630].
  17. Keogh, M. J., Daud, D., Pyle, A., Duff, J., Griffin, H., He, L., Alston, C. L., Steele, H., Taggart, S., Basu, A. P., Taylor, R. W., Horvath, R., Ramesh, V., and Chinnery, P. F. (2014) A novel de novo STXBP1 mutation is associated with mitochondrial complex I deficiency and late-onset juvenile-onset parkinsonism. Neurogenetics. [PM:25418441].
  18. Tsukada, H. (2014) The Use of (18)F-BCPP-EF as a PET Probe for Complex I Activity in the Brain. Methods Enzymol. 547:417-431. [PM:25416368].
  19. Pogson, J. H., Ivatt, R. M., Sanchez-Martinez, A., Tufi, R., Wilson, E., Mortiboys, H., and Whitworth, A. J. (2014) The Complex I Subunit NDUFA10 Selectively Rescues Drosophila pink1 Mutants through a Mechanism Independent of Mitophagy. PLoS. Genet. 10:e1004815- [PM:25412178].
  20. De, R. D., Signorile, A., Santeramo, A., Larizza, M., Lattanzio, P., Capitanio, G., and Papa, S. (2014) Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain. Biochim. Biophys. Acta 1853:183-191. [PM:25409931].
  21. Finsterer, J. and Zarrouk-Mahjoub, S. (2014) Implications of non-compaction in association with respiratory chain complex-I deficiency. Cardiol. Young.1-2. [PM:25403618].
  22. Bruch, J., Xu, H., De, A. A., and Hoglinger, G. (2014) Mitochondrial Complex 1 Inhibition Increases 4-Repeat Isoform Tau by SRSF2 Upregulation. PLoS. ONE. 9:e113070- [PM:25402454].
  23. Hsu, Y. W., Wang, H. J., Hsieh, M. H., Hsieh, H. L., and Jauh, G. Y. (2014) Arabidopsis mTERF15 Is Required for Mitochondrial nad2 Intron 3 Splicing and Functional Complex I Activity. PLoS. ONE. 9:e112360- [PM:25402171].
  24. Chen, Z., Zhao, Z., Ye, Q., Chen, Y., Pan, X., Sun, B., Huang, H., and Zheng, A. (2014) Mild clinical manifestation and unusual recovery upon coenzyme Q10 treatment in the first Chinese Leigh syndrome pedigree with mutation m.10197 G>A. Mol. Med. Rep. [PM:25384404].
  25. Chang, E., Liu, H., Unterschemmann, K., Ellinghaus, P., Liu, S., Gekeler, V., Cheng, Z., Berndorff, D., and Gambhir, S. S. (2014) 18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243. Clin. Cancer Res. [PM:25381339].
  26. Ullmann, E., Tan, T. C., Gundinger, T., Herwig, C., Divne, C., and Spadiut, O. (2014) A novel cytosolic NADH:quinone oxidoreductase from Methanothermobacter marburgensis. Biosci. Rep. [PM:25372605].
  27. Ramos, A. R., Grein, F., Oliveira, G. P., Venceslau, S. S., Keller, K. L., Wall, J. D., and Pereira, I. A. (2014) The FlxABCD-HdrABC proteins correspond to a novel NADH dehydrogenase/heterodisulfide reductase widespread in anaerobic bacteria and involved in ethanol metabolism in Desulfovibrio vulgaris Hildenborough. Environ. Microbiol. [PM:25367508].
  28. Djoko, K. Y., Donnelly, P. S., and McEwan, A. G. (2014) Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes. Metallomics. 6:2250-2259. [PM:25366244].
  29. Gielisch, I. and Meierhofer, D. (2014) Metabolome and Proteome Profiling of Complex I Deficiency Induced by Rotenone. J. Proteome. Res. [PM:25361611].
  30. Zhu, Y., Wang, Z., Ni, J., Zhang, Y., Chen, M., Cai, J., Li, X., Zhang, W., and Zhang, C. (2014) Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese. J. Hum. Genet. [PM:25354934].
  31. Luengo, A., Sullivan, L. B., and Heiden, M. G. (2014) Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy. BMC. Biol. 12:82- [PM:25347702].
  32. Gueven, N. and Faldu, D. (2013) Therapeutic strategies for Leber's hereditary optic neuropathy: A current update. Intractable. Rare. Dis. Res. 2:130-135. [PM:25343117].
  33. Chu, M. J., Hickey, A. J., Jiang, Y., Petzer, A., Bartlett, A. S., and Phillips, A. R. (2014) Mitochondrial dysfunction in rat steatotic liver is due to a defect in Complex-I making them more susceptible to prolonged cold ischemia. Liver Transpl. [PM:25312517].
  34. Bird, M. J., Wijeyeratne, X. W., Komen, J. C., Laskowski, A., Ryan, M. T., Thorburn, D. R., and Frazier, A. E. (2014) Neuronal and astrocyte dysfunction diverges from embryonic fibroblasts in the Ndufs4fky/fky mouse. Biosci. Rep. [PM:25312000].
  35. Zhou, Q., Liu, C., Liu, W., Zhang, H., Zhang, R., Liu, J., Zhang, J., Xu, C., Liu, L., Huang, S., and Chen, L. (2014) Rotenone induction of hydrogen peroxide inhibits mTOR-mediated S6K and 4E-BP1/eIF4E pathways, leading to neuronal apoptosis. Toxicol. Sci. [PM:25304210].
  36. Fontaine, E. (2014) Metformin and respiratory chain complex I: the last piece of the puzzle? Biochem. J. 463:e3-e5. [PM:25301073].
  37. Michelini, L. G., Benevento, C. E., Rossato, F. A., Siqueira-Santos, E. S., and Castilho, R. F. (2014) Effects of Partial Inhibition of Respiratory Complex I on HO Production by Isolated Brain Mitochondria in Different Respiratory States. Neurochem. Res. [PM:25287903].
  38. Belevich, N., Belevich, G., and Verkhovskaya, M. (2014) Real-time optical studies of respiratory Complex I turnover. Biochim. Biophys. Acta 1837:1973-1980. [PM:25283488].
  39. Choi, W. S. and Xia, Z. (2014) Maneb-induced dopaminergic neuronal death is not affected by loss of mitochondrial complex I activity: results from primary mesencephalic dopaminergic neurons cultured from individual Ndufs4+/+ and Ndufs4-/- mouse embryos. Neuroreport 25:1350-1355. [PM:25275677].
  40. Kostner, D., Luchterhand, B., Junker, A., Volland, S., Daniel, R., Buchs, J., Liebl, W., and Ehrenreich, A. (2014) The consequence of an additional NADH dehydrogenase paralog on the growth of Gluconobacter oxydans DSM3504. Appl. Microbiol. Biotechnol. [PM:25267158].
  41. Nascimento, C., Kim, H. K., Young, L. T., Mendonca, K. M., Grinberg, L. T., Lafer, B., and Andreazza, A. C. (2014) Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J. Neural Transm. [PM:25261015].
  42. Li, L., Dong, X., Shu, B., Wang, Z., Hu, Q., and Zhong, G. (2014) Iron-sulfur protein in mitochondrial complexes of Spodoptera litura as potential site for ROS generation. J. Insect Physiol [PM:25257538].
  43. Gershoni, M., Levin, L., Ovadia, O., Toiw, Y., Shani, N., Dadon, S., Barzilai, N., Bergman, A., Atzmon, G., Wainstein, J., Tsur, A., Nijtmans, L., Glaser, B., and Mishmar, D. (2014) Disrupting mitochondrial-nuclear co-evolution affects OXPHOS complex I integrity and impacts human health. Genome Biol. Evol. [PM:25245408].
  44. Schulte, M., Mattay, D., Kriegel, S., Hellwig, P., and Friedrich, T. (2014) Inhibition of the Escherichia coli respiratory complex I by Zn2+. Biochemistry [PM:25238255].
  45. Sanders, L. H., Howlett, E. H., McCoy, J., and Greenamyre, J. T. (2014) Mitochondrial DNA Damage as a Peripheral Biomarker for Mitochondrial Toxin Exposure in Rats. Toxicol. Sci. [PM:25237061].
  46. Bazil, J. N., Pannala, V. R., Dash, R. K., and Beard, D. A. (2014) Determining the Origins of Superoxide and Hydrogen Peroxide in the Mammalian NADH:Ubiquinone Oxidoreductase. Free Radic. Biol. Med. [PM:25236739].
  47. Kriegel, S., Uchida, T., Osawa, M., Friedrich, T., and Hellwig, P. (2014) A biomimetic environment to study E. coli Complex I through Surface Enhanced IR Absorption Spectroscopy (SEIRAS). Biochemistry [PM:25225967].
  48. Scheffler, I. E. (2014) Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency. J. Inherit. Metab Dis. [PM:25224827].
  49. McKenzie, M., Chiotis, M., Hroudova, J., Sanchez, M. I., Lim, S. C., Cook, M. J., McKelvie, P., Cotton, R. G., Murphy, M., John, J. C., and Trounce, I. A. (2014) Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain. Hum. Mutat. [PM:25219341].
  50. Sing, A., Tsatskis, Y., Fabian, L., Hester, I., Rosenfeld, R., Serricchio, M., Yau, N., Bietenhader, M., Shanbhag, R., Jurisicova, A., Brill, J. A., McQuibban, G. A., and McNeill, H. (2014) The atypical cadherin fat directly regulates mitochondrial function and metabolic state. Cell 158:1293-1308. [PM:25215488].
  51. Vinothkumar, K. R., Zhu, J., and Hirst, J. (2014) Architecture of mammalian respiratory complex I. Nature [PM:25209663].
  52. Salama, M., El-Morsy, D., El-Gamal, M., Shabka, O., and Mohamed, W. M. (2014) Mitochondrial complex I inhibition as a possible mechanism of chlorpyrifos induced neurotoxicity. Ann. Neurosci. 21:85-89. [PM:25206071].
  53. Steuber, J., Halang, P., Vorburger, T., Steffen, W., Vohl, G., and Fritz, G. (2014) Central role of the Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) in sodium bioenergetics of Vibrio cholerae. Biol. Chem. [PM:25205724].
  54. Zhang, J., Jiang, P., Jin, X., Liu, X., Zhang, M., Xie, S., Gao, M., Zhang, S., Sun, Y. H., Zhu, J., Ji, Y., Wei, Q. P., Tong, Y., and Guan, M. X. (2014) Leber's hereditary optic neuropathy caused by the homoplasmic ND1 m.3635G>A mutation in nine Han Chinese families. Mitochondrion. 18C:18-26. [PM:25194554].
  55. Gonzalez-Siso, M. I., Tourino, A., Vizoso, A., Pereira-Rodriguez, A., Rodriguez-Belmonte, E., Becerra, M., and Cerdan, M. E. (2014) Improved bioethanol production in an engineered Kluyveromyces lactis strain shifted from respiratory to fermentative metabolism by deletion of NDI1. Microb. Biotechnol. [PM:25186243].
  56. Jiang, Z., Yu, J., Xia, B., and Zhuo, G. (2014) Mitochondrial tRNA 15891C>G mutation was not associated with Leber's hereditary optic neuropathy in Han Chinese patients. Mitochondrial. DNA1-3. [PM:25186221].
  57. Miao, Y. J., Xu, X. F., Xu, F., Chen, Y., Chen, J. W., and Li, X. (2014) The structure-activity relationships of mono-THF ACGs on mitochondrial complex I with a molecular modelling study. Nat. Prod. Res. 28:1929-1935. [PM:25183444].
  58. Ashmore, T., Fernandez, B. O., Branco-Price, C., West, J. A., Cowburn, A. S., Heather, L. C., Griffin, J. L., Johnson, R. S., Feelisch, M., and Murray, A. J. (2014) Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart. J. Physiol [PM:25172947].
  59. Poursadegh, Z. A., Ghorbian, S., Abkar, M., Poursadegh Zonouzi, A. A., and Azadi, A. (2014) Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis. J. Neurol. Sci. [PM:25172194].
  60. Abdin, A. and Sarhan, N. (2014) Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity. Can. J. Physiol Pharmacol.1-9. [PM:25162205].
  61. McDowall, J. S., Murphy, B. J., Haumann, M., Palmer, T., Armstrong, F. A., and Sargent, F. (2014) Bacterial formate hydrogenlyase complex. Proc. Natl. Acad. Sci. U. S. A [PM:25157147].
  62. La, M. C., Carbonelli, M., Barboni, P., Sadun, A. A., and Carelli, V. (2014) Medical management of hereditary optic neuropathies. Front Neurol. 5:141- [PM:25132831].
  63. Jin, Z., Wei, W., Yang, M., Du, Y., and Wan, Y. (2014) Mitochondrial Complex I Activity Suppresses Inflammation and Enhances Bone Resorption by Shifting Macrophage-Osteoclast Polarization. Cell Metab [PM:25130399].
  64. Awasthy, D., Ambady, A., Narayana, A., Morayya, S., and Sharma, U. (2014) Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro. Gene 550:110-116. [PM:25128581].
  65. Gospodaryov, D. V., Lushchak, O. V., Rovenko, B. M., Perkhulyn, N. V., Gerards, M., Tuomela, T., and Jacobs, H. T. (2014) Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochim. Biophys. Acta 1837:1861-1869. [PM:25124484].
  66. Worth, A. J., Basu, S. S., Snyder, N. W., Mesaros, C., and Blair, I. A. (2014) Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid beta-oxidation supporting acetyl-coenzyme A levels. J. Biol. Chem. [PM:25122772].
  67. Wulfhorst, H., Franken, L. E., Wessinghage, T., Boekema, E. J., and Nowaczyk, M. M. (2014) The 5 kDa Protein NdhP Is Essential for Stable NDH-1L Assembly in Thermosynechococcus elongatus. PLoS. ONE. 9:e103584- [PM:25119998].
  68. Tapia, E., Sanchez-Lozada, L. G., Garcia-Nino, W. R., Garcia, E., Cerecedo, A., Garcia-Arroyo, F. E., Osorio, H., Arellano, A., Cristobal-Garcia, M., Loredo, M. L., Molina-Jijon, E., Hernandez-Damian, J., Negrette-Guzman, M., Zazueta, C., Huerta-Yepez, S., Reyes, J. L., Madero, M., and Pedraza-Chaverri, J. (2014) Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I. Free Radic. Res.1-36. [PM:25119790].
  69. Radad, K., Scheller, D., Rausch, W. D., Reichmann, H., and Gille, G. (2014) Neuroprotective effect of rotigotine against complex I inhibitors, MPP+ and rotenone, in primary mesencephalic cell culture. Folia Neuropathol. 52:179-186. [PM:25118903].
  70. Miller, D. K., Menezes, M. J., Simons, C., Riley, L. G., Cooper, S. T., Grimmond, S. M., Thorburn, D. R., Christodoulou, J., and Taft, R. J. (2014) Rapid Identification of a Novel Complex I MT-ND3 m.10134C>A Mutation in a Leigh Syndrome Patient. PLoS. ONE. 9:e104879- [PM:25118196].
  71. Kim, E. M., Park, J. K., Hwang, S. G., Kim, W. J., Liu, Z. G., Kang, S. W., and Um, H. D. (2014) Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins. Oncotarget. [PM:25115399].
  72. Solotoff, V., Moseler, R., and Schulte, U. (2014) Two pentatricopeptide repeat domain proteins are required for the synthesis of respiratory complex I. Curr. Genet. [PM:25108509].
  73. Li, H., Chen, G., Ma, W., and Li, P. A. (2014) Water-soluble coenzyme q10 inhibits nuclear translocation of apoptosis inducing factor and cell death caused by mitochondrial complex I inhibition. Int. J. Mol. Sci. 15:13388-13400. [PM:25089873].
  74. Burman, J. L., Itsara, L. S., Kayser, E. B., Suthammarak, W., Wang, A. M., Kaeberlein, M., Sedensky, M. M., Morgan, P. G., and Pallanck, L. J. (2014) A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer. Dis. Model. Mech. [PM:25085991].
  75. Han, G., Casson, R., Chidlow, G., and Wood, J. P. (2014) The Mitochondrial Complex I Inhibitor Rotenone Induces Endoplasmic Reticulum Stress and Activation of GSK3beta in Cultured Rat Retinal Cells. Invest Ophthalmol. Vis. Sci. [PM:25082888].
  76. Giordano, S., Dodson, M., Ravi, S., Redmann, M., Ouyang, X., Darley Usmar, V. M., and Zhang, J. (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure. J. Neurochem. [PM:25081478].
  77. Jovanovic, D. S., Dordevic, M., Savkovic, U., and Lazarevic, J. (2014) The effect of mitochondrial complex I inhibitor on longevity of short-lived and long-lived seed beetles and its mitonuclear hybrids. Biogerontology. 15:487-501. [PM:25078074].
  78. Nakamaru-Ogiso, E., Narayanan, M., and Sakyiama, J. A. (2014) Roles of semiquinone species in proton pumping mechanism by complex I. J. Bioenerg. Biomembr. [PM:25077450].
  79. Heiske, M., Nazaret, C., and Mazat, J. P. (2014) Modeling the respiratory chain complexes with biothermokinetic equati. Biochim. Biophys. Acta [PM:25064016].
  80. Tan, P., Feng, Z., Zhang, L., Hou, T., and Li, Y. (2014) The mechanism of proton translocation in respiratory complex I from molecular dynamics. J. Recept. Signal. Transduct. Res.1-10. [PM:25055024].
  81. Barquera, B. (2014) The sodium pumping NADH:quinone oxidoreductase (Na-NQR), a unique redox-driven ion pump. J. Bioenerg. Biomembr. [PM:25052842].
  82. Kokaze, A., Yoshida, M., Ishikawa, M., Matsunaga, N., Karita, K., Ohtsu, T., Ochiai, H., Shirasawa, T., Nanri, H., Baba, Y., Hoshino, H., and Takashima, Y. (2014) NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study. Tob. Induc. Dis. 12:11- [PM:25031572].
  83. Vartak, R. S., Semwal, M. K., and Bai, Y. (2014) An update on complex I assembly: the assembly of players. J. Bioenerg. Biomembr. [PM:25030182].
  84. Friedrich, T. (2014) On the mechanism of respiratory complex I. J. Bioenerg. Biomembr. [PM:25022766].
  85. Strickland, M., Juarez, O., Neehaul, Y., Cook, D. A., Barquera, B., and Hellwig, P. (2014) The Conformational Changes Induced by Ubiquinone Binding in the Na+-pumping NADH:ubiquinone Oxidoreductase (NQR) are Kinetically Controlled by Conserved Glycines 140 and 141 of the NqrB Subunit. J. Biol. Chem. [PM:25006248].
  86. Pepe, S., Mentzer, R. M., Jr., and Gottlieb, R. A. (2014) Cell-permeable protein therapy for complex I dysfunction. J. Bioenerg. Biomembr. [PM:25005682].
  87. Vohl, G., Nedielkov, R., Claussen, B., Casutt, M. S., Vorburger, T., Diederichs, K., Moller, H. M., Steuber, J., and Fritz, G. (2014) Crystallization and preliminary analysis of the NqrA and NqrC subunits of the Na(+)-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae. Acta Crystallogr. F. Struct. Biol. Commun. 70:987-992. [PM:25005105].
  88. Murai, M. and Miyoshi, H. (2014) Chemical modifications of respiratory complex I for structural and functional studies. J. Bioenerg. Biomembr. [PM:24993592].
  89. Gutierrez-Sanz, O., Olea, D., Pita, M., Batista, A. P., Alonso, A., Pereira, M. M., Velez, M., and De Lacey, A. L. (2014) Reconstitution of respiratory complex I on a biomimetic membrane supported on gold electrodes. Langmuir 30:9007-9015. [PM:24988043].
  90. Yagi, T. and Matsuno-Yagi, A. (2014) Respiratory complex I: hop (structure), step (reaction mechanism) and jump (potential remedy). J. Bioenerg. Biomembr. [PM:24986732].
  91. Sato, M., Torres-Bacete, J., Sinha, P. K., Matsuno-Yagi, A., and Yagi, T. (2014) Essential regions in the membrane domain of bacterial complex I (NDH-1): the machinery for proton translocation. J. Bioenerg. Biomembr. [PM:24973951].
  92. Wu, L., Peng, J., Ma, Y., He, F., Deng, X., Wang, G., Lifen, Y., and Yin, F. (2014) Leukodystrophy associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFAF1 gene. Mitochondrial. DNA1-4. [PM:24963768].
  93. de Sousa, R. T., Streck, E. L., Zanetti, M. V., Ferreira, G. K., Diniz, B. S., Brunoni, A. R., Busatto, G. F., Gattaz, W. F., and Machado-Vieira, R. (2014) Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes. Psychopharmacology (Berl) [PM:24961563].
  94. Duarte, M. and Tomas, A. M. (2014) The mitochondrial complex I of trypanosomat. J. Bioenerg. Biomembr. [PM:24961227].
  95. Hur, J. H., Stork, D. A., and Walker, D. W. (2014) Complex-I-ty in aging. J. Bioenerg. Biomembr. [PM:24961226].
  96. Colas, d. F.-S., Falcon de, L. A., Li, Y., Lowe, E., Tanz, S., Smith, C., Bevan, M., and Small, I. (2014) THE PPR PROTEINS TANG2 AND OTP439 ARE INVOLVED IN THE SPLICING OF THE MULTIPARTITE nad5 TRANSCRIPT ENCODING A SUBUNIT OF MITOCHONDRIAL COMPLEX I. Plant Physiol [PM:24958715].
  97. Kashani, A., Thiffault, I., Dilenge, M. E., Saint-Martin, C., Guerrero, K., Tran, L. T., Shoubridge, E., van der Knaap, M. S., Braverman, N., and Bernard, G. (2014) A homozygous mutation in the NDUFS1 gene presents with a mild cavitating leukoencephalopathy. Neurogenetics. [PM:24952175].
  98. Wessels, B., Ciapaite, J., van den Broek, N. M., Nicolay, K., and Prompers, J. J. (2014) Metformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent manner. PLoS. ONE. 9:e100525- [PM:24950069].
  99. Sazanov, L. A. (2014) The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. J. Bioenerg. Biomembr. [PM:24943718].
  100. Luth, E. S., Stavrovskaya, I. G., Bartels, T., Kristal, B. S., and Selkoe, D. J. (2014) Soluble, Prefibrillar alpha-Synuclein Oligomers Promote Complex I-Dependent, Ca2+-Induced Mitochondrial Dysfunction. J. Biol. Chem. [PM:24942732].
  101. Murakami, S., Miyazaki, I., Sogawa, N., Miyoshi, K., and Asanuma, M. (2014) Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice. Neurotox. Res. [PM:24923464].
  102. Tsukada, H., Nishiyama, S., Ohba, H., Kanazawa, M., Kakiuchi, T., and Harada, N. (2014) Comparing amyloid-beta deposition, neuroinflammation, glucose metabolism, and mitochondrial complex I activity in brain: a PET study in aged monkeys. Eur. J. Nucl. Med. Mol. Imaging [PM:24919653].
  103. Hong, J., Kim, B. W., Choo, H. J., Park, J. J., Yi, J. S., Yu, D. M., Lee, H., Yoon, G. S., Lee, J. S., and Ko, Y. G. (2014) Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation. J. Biol. Chem. [PM:24895128].
  104. La, M. C., Caporali, L., Gandini, F., Olivieri, A., Toni, F., Nassetti, S., Brunetto, D., Stipa, C., Scaduto, C., Parmeggiani, A., Tonon, C., Lodi, R., Torroni, A., and Carelli, V. (2014) Association of the mtDNA m.4171C>A/MT-ND1 mutation with both optic neuropathy and bilateral brainstem lesions. BMC. Neurol. 14:116- [PM:24884847].
  105. Muras, V., Claussen, B., Karuppasamy, M., Schaffitzel, C., and Steuber, J. (2014) Continuous fluorescence based measurement of redox driven sodium ion translocation. Anal. Biochem. [PM:24862438].
  106. McTernan, P. M., Chandrayan, S. K., Wu, C. H., Vaccaro, B. J., Lancaster, W. A., Yang, Q., Fu, D., Hura, G. L., Tainer, J. A., and Adams, M. W. (2014) Intact Functional Fourteen-Subunit Respiratory Membrane Bound [NiFe]-Hydrogenase Complex of the Hyperthermophilic Archaeon Pyrococcus furiosus. J. Biol. Chem. [PM:24860091].
  107. Wheaton, W. W., Weinberg, S. E., Hamanaka, R. B., Soberanes, S., Sullivan, L. B., Anso, E., Glasauer, A., Dufour, E., Mutlu, G. M., Budigner, G. S., and Chandel, N. S. (2014) Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 3:e02242- [PM:24843020].
  108. Zurita, O., Silva, N. L., Sasarman, F., and Shoubridge, E. A. (2014) The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis. Hum. Mol. Genet. [PM:24838397].
  109. Negishi, Y., Hattori, A., Takeshita, E., Sakai, C., Ando, N., Ito, T., Goto, Y. I., and Saitoh, S. (2014) Homoplasmy of a mitochondrial 3697G>A mutation causes Leigh syndrome. J. Hum. Genet. [PM:24830958].
  110. Ai, Q., Jing, Y., Jiang, R., Lin, L., Dai, J., Che, Q., Zhou, D., Jia, M., Wan, J., and Zhang, L. (2014) Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice. Int. Immunopharmacol. 21:200-207. [PM:24830863].
  111. Miwa, S., Jow, H., Baty, K., Johnson, A., Czapiewski, R., Saretzki, G., Treumann, A., and Von, Z. T. (2014) Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice. Nat. Commun. 5:3837- [PM:24815183].
  112. Minato, Y., Fassio, S. R., Kirkwood, J. S., Halang, P., Quinn, M. J., Faulkner, W. J., Aagesen, A. M., Steuber, J., Stevens, J. F., and Hase, C. C. (2014) Roles of the Sodium-Translocating NADH:Quinone Oxidoreductase (Na+-NQR) on Vibrio cholerae Metabolism, Motility and Osmotic Stress Resistance. PLoS. ONE. 9:e97083- [PM:24811312].
  113. Ciscato, F., Sciacovelli, M., Villano, G., Turato, C., Bernardi, P., Rasola, A., and Pontisso, P. (2013) SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. Oncotarget. [PM:24810714].
  114. Reyes-Prieto, A., Barquera, B., and Juarez, O. (2014) Origin and Evolution of the Sodium -Pumping NADH: Ubiquinone Oxidoreductase. PLoS. ONE. 9:e96696- [PM:24809444].
  115. Schertl, P. and Braun, H. P. (2014) Respiratory electron transfer pathways in plant mitochondria. Front Plant Sci. 5:163- [PM:24808901].
  116. Piel, S., Ehinger, J. K., Elmer, E., and Hansson, M. J. (2014) Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition. Acta Physiol (Oxf) [PM:24801139].
  117. Martinez-Romero, I., Herrero-Martin, M. D., Llobet, L., Emperador, S., Martin-Navarro, A., Narberhaus, B., Ascaso, F. J., Lopez-Gallardo, E., Montoya, J., and Ruiz-Pesini, E. (2014) New MT-ND1 pathologic mutation for Leber hereditary optic neuropathy. Clin. Experiment. Ophthalmol. [PM:24800637].
  118. Guney, O., Ak, H., Atay, S., Ozkaya, A. B., and Aydin, H. H. (2014) Mitochondrial DNA polymorphisms associated with longevity in the Turkish population. Mitochondrion. 17C:7-13. [PM:24792352].
  119. Cao, Y., Wang, Y., Abi Saab, W. F., Yang, F., Pessin, J. E., and Backer, J. M. (2014) NRBF2 Regulates Macroautophagy as a Component of Vps34 Complex I. Biochem. J. [PM:24785657].
  120. Kaila, V. R., Wikstrom, M., and Hummer, G. (2014) Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I. Proc. Natl. Acad. Sci. U. S. A [PM:24778264].
  121. Forkink, M., Manjeri, G. R., Liemburg-Apers, D. C., Nibbeling, E., Blanchard, M., Wojtala, A., Smeitink, J. A., Wieckowski, M. R., Willems, P. H., and Koopman, W. J. (2014) Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V. Biochim. Biophys. Acta [PM:24769419].
  122. Hegde, V. R., Vogel, R., and Feany, M. B. (2014) Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum. Mol. Genet. [PM:24760769].
  123. Zhang, Q., Zhang, J., Jiang, C., Qin, J., Ke, K., and Ding, F. (2014) Involvement Of ERK1/2 Pathway In Neuroprotective Effects Of Pyrroloquinoline Quinine Against Rotenone-Induced SH-SY5Y Cell Injury. Neuroscience [PM:24755484].
  124. Frolova, M. S. and Vekshin, N. L. (2014) Stabilization of NADH-dehydrogenase in Mitochondria by Guanosine Phosphates and Adenosine Phosphates. J. Fluoresc. [PM:24722920].
  125. Gioran, A., Nicotera, P., and Bano, D. (2014) Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway. Cell Death. Dis. 5:e1175- [PM:24722300].
  126. Rak, M. and Rustin, P. (2014) Supernumerary subunits NDUFA3, NDUFA5 and NDUFA12 are required for the formation of the extramembrane arm of human mitochondrial complex I. FEBS Lett. [PM:24717771].
  127. Carletti, B., Piermarini, E., Tozzi, G., Travaglini, L., Torraco, A., Pastore, A., Sparaco, M., Petrillo, S., Carrozzo, R., Bertini, E., and Piemonte, F. (2014) Frataxin Silencing Inactivates Mitochondrial Complex I in NSC34 Motoneuronal Cells and Alters Glutathione Homeostasis. Int. J. Mol. Sci. 15:5789-5806. [PM:24714088].
  128. Domingues, S., Isidoro, L., Rocha, D., and Sales, M. J. (2014) Neurofibromatosis Type 1: A Novel NF1 Mutation Associated with Mitochondrial Complex I Deficiency. Case. Rep. Genet. 2014:423071- [PM:24711935].
  129. Schurig-Briccio, L. A., Yano, T., Rubin, H., and Gennis, R. B. (2014) Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines. Biochim. Biophys. Acta [PM:24709059].
  130. Leng, Y., Liu, Y., Fang, X., Li, Y., Yu, L., Yuan, Y., and Wang, Z. (2014) The mitochondrial DNA 10197 G > A mutation causes MELAS/Leigh overlap syndrome presenting with acute auditory agnosia. Mitochondrial. DNA [PM:24708134].
  131. Angerer, H., Radermacher, M., Malkowska, M., Steger, M., Zwicker, K., Heide, H., Wittig, I., Brandt, U., and Zickermann, V. (2014) The LYR protein subunit NB4M/NDUFA6 of mitochondrial complex I anchors an acyl carrier protein and is essential for catalytic activity. Proc. Natl. Acad. Sci. U. S. A 111:5207-5212. [PM:24706851].
  132. Chouchani, E. T., Methner, C., Buonincontri, G., Hu, C. H., Logan, A., Sawiak, S. J., Murphy, M. P., and Krieg, T. (2014) Complex I deficiency due to selective loss of ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS. ONE. 9:e94157- [PM:24705922].
  133. Salehi, M. H., Kamalidehghan, B., Houshmand, M., Yong, M. G., Sadeghizadeh, M., Aryani, O., and Nafissi, S. (2014) Gene Expression Profiling of Mitochondrial Oxidative Phosphorylation (OXPHOS) Complex I in Friedreich Ataxia (FRDA) Patients. PLoS. ONE. 9:e94069- [PM:24705504].
  134. Kang, P. T., Chen, C. L., Zen, P., Guarini, G., and Chen, Y. R. (2014) BCNU-Induced gR2 DEFECT mediates S-glutathionylation OF Complex I and RESPIRATORY uncoupling in myocardium. Biochem. Pharmacol. [PM:24704251].
  135. Moran, M., Delmiro, A., Blazquez, A., Ugalde, C., Arenas, J., and Martin, M. A. (2014) Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease. Biochim. Biophys. Acta 1842:1059-1070. [PM:24704045].
  136. Camilleri, A. and Vassallo, N. (2014) The Centrality of Mitochondria in the Pathogenesis and Treatment of Parkinson's Disease. CNS. Neurosci. Ther. [PM:24703487].
  137. Finsterer, J., Melichart, M., and Wohrer, A. (2014) Complex-I defect with minimal manifestations. Arch. Med. Sci. 10:200-202. [PM:24701236].
  138. Xu, A., Szczepanek, K., Maceyka, M. W., Ross, T., Bowler, E., Hu, Y., Kenny, B., Mehfoud, C., Desai, P. N., Baumgarten, C. M., Chen, Q., and Lesnefsky, E. J. (2014) Transient Complex I Inhibition at the Onset of Reperfusion by Extracellular Acidification Decreases Cardiac Injury. Am. J. Physiol Cell Physiol [PM:24696146].
  139. Barker, C. S., Meshcheryakova, I. V., Sasaki, T., Roy, M. C., Sinha, P. K., Yagi, T., and Samatey, F. A. (2014) Randomly selected suppressor mutations in genes for NADH:quinone oxidoreductase-1, which rescue motility of a Salmonella ubiquinone-biosynthesis mutant strain. Microbiology [PM:24692644].
  140. Rygiel, K. A., Grady, J. P., and Turnbull, D. M. (2014) Respiratory chain deficiency in aged spinal motor neurons. Neurobiol. Aging [PM:24684792].
  142. Masuya, T., Murai, M., Ifuku, K., Morisaka, H., and Miyoshi, H. (2014) Site-Specific Chemical Labeling of Mitochondrial Respiratory Complex I Through Ligand-Directed Tosylate Chemistry. Biochemistry [PM:24660830].
  143. Wu, Z. Z., Li, H. M., Bin, S. Y., Ma, J., He, H. L., Li, X. F., Gong, F. L., and Lin, J. T. (2014) Sequence analysis of mitochondrial ND1 gene can reveal the genetic structure and origin of Bactrocera dorsalis s.s. BMC. Evol. Biol. 14:55- [PM:24655832].
  144. Morais, V. A., Haddad, D., Craessaerts, K., De Bock, P. J., Swerts, J., Vilain, S., Aerts, L., Overbergh, L., Grunewald, A., Seibler, P., Klein, C., Gevaert, K., Verstreken, P., and De, S. B. (2014) PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science [PM:24652937].
  145. Musicco, C., Cormio, A., Calvaruso, M. A., Iommarini, L., Gasparre, G., Porcelli, A. M., Timperio, A. M., Zolla, L., and Gadaleta, M. N. (2014) Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I. Mol. Biosyst. [PM:24643264].
  146. Lechauve, C., Augustin, S., Cwerman-Thibault, H., Reboussin, E., Roussel, D., Lai-Kuen, R., Saubamea, B., Sahel, J. A., Debeir, T., and Corral-Debrinski, M. (2014) Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice. Mol. Ther. [PM:24622090].
  147. Jia, F., Song, N., Zhao, C., Xie, J., and Jiang, H. (2014) Unexpected improvements of spatial learning and memory abilities in chronic rotenone intoxicated mice. PLoS. ONE. 9:e91641- [PM:24618574].
  148. Carriere, C. H., Kang, N. H., and Niles, L. P. (2014) Neuroprotection by valproic acid in an intrastriatal rotenone model of Parkinson's disease. Neuroscience 267C:114-121. [PM:24613722].
  149. Yu-Wai-Man, P., Votruba, M., Moore, A. T., and Chinnery, P. F. (2014) Treatment strategies for inherited optic neuropathies: past, present and future. Eye (Lond) [PM:24603424].
  150. Mansergh, F. C., Chadderton, N., Kenna, P. F., Gobbo, O. L., and Farrar, G. J. (2014) Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy. Eur. J. Hum. Genet. [PM:24569607].
  151. Babot, M., Birch, A., Labarbuta, P., and Galkin, A. (2014) Characterisation of the active/de-active transition of mitochondrial complex I. Biochim. Biophys. Acta [PM:24569053].
  152. Braun, H. P., Binder, S., Brennicke, A., Eubel, H., Fernie, A. R., Finkemeier, I., Klodmann, J., Konig, A. C., Kuhn, K., Meyer, E., Obata, T., Schwarzlander, M., Takenaka, M., and Zehrmann, A. (2014) The life of plant mitochondrial complex I. Mitochondrion. [PM:24561573].
  153. Drose, S., Brandt, U., and Wittig, I. (2014) Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation. Biochim. Biophys. Acta [PM:24561273].
  154. Karuppagounder, S. S., Bhattacharya, D., Ahuja, M., Suppiramaniam, V., Deruiter, J., Clark, R., and Dhanasekaran, M. (2014) Elucidate the Neurotoxic Effects of MDMA & its analogues. Life Sci. [PM:24560859].
  155. Babot, M., Labarbuta, P., Birch, A., Kee, S., Fuszard, M., Botting, C. H., Wittig, I., Heide, H., and Galkin, A. (2014) ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I. Biochim. Biophys. Acta [PM:24560811].
  156. Liu, T., Chen, L., Kim, E., Tran, D., Phinney, B. S., and Knowlton, A. A. (2014) Mitochondrial proteome remodeling in ischemic heart failure. Life Sci. [PM:24548633].
  157. Shimada, S., Shinzawa-Itoh, K., Amano, S., Akira, Y., Miyazawa, A., Tsukihara, T., Tani, K., Gerle, C., and Yoshikawa, S. (2014) Three-dimensional structure of bovine heart NADH: ubiquinone oxidoreductase (complex I) by electron microscopy of a single negatively stained two-dimensional crystal. Microscopy. (Oxf) [PM:24523515].
  158. Roelofs, S., Manjeri, G. R., Willems, P. H., Scheffer, G. J., Smeitink, J. A., and Driessen, J. J. (2014) Isoflurane anesthetic hypersensitivity and progressive respiratory depression in a mouse model with isolated mitochondrial complex I deficiency. J. Anesth. [PM:24522811].
  159. Quinlan, C. L., Goncalves, R. L., Hey-Mogensen, M., Yadava, N., Bunik, V. I., and Brand, M. D. (2014) The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates than Complex I. J. Biol. Chem. [PM:24515115].
  160. Ma, Y. Y., Wu, T. F., Liu, Y. P., Wang, Q., Li, X. Y., Ding, Y., Song, J. Q., Yang, Y. L., and Zou, L. P. (2014) A study of 133 Chinese children with mitochondrial respiratory chain complex I deficiency. Clin. Genet. [PM:24502327].
  161. Kjellin, H., Johansson, H., Hoog, A., Lehtio, J., Jakobsson, P. J., and Kjellman, M. (2014) Differentially expressed proteins in malignant and benign adrenocortical tumors. PLoS. ONE. 9:e87951- [PM:24498411].
  162. Liu, J., Yin, Y., Song, Z., Li, Y., Jiang, S., Shao, C., and Wang, Z. (2014) NADH: flavin oxidoreductase/NADH oxidase and ROS regulate microsclerotium development in Nomuraea rileyi. World J. Microbiol. Biotechnol. [PM:24497186].
  163. Chang, L., Liu, X., Liu, J., Li, H., Yang, Y., Liu, J., Guo, Z., Xiao, K., Zhang, C., Liu, J., Zhao-Wilson, X., and Long, J. (2014) D-Galactose Induces a Mitochondrial Complex I Deficiency in Mouse Skeletal Muscle: Potential Benefits of Nutrient Combination in Ameliorating Muscle Impairment. J. Med. Food [PM:24476218].
  164. Steinsiek, S., Stagge, S., and Bettenbrock, K. (2014) Analysis of Escherichia coli Mutants with a Linear Respiratory Chain. PLoS. ONE. 9:e87307- [PM:24475268].
  165. Tsukada, H., Nishiyama, S., Fukumoto, D., Kanazawa, M., and Harada, N. (2014) Novel PET Probes 18F-BCPP-EF and 18F-BCPP-BF for Mitochondrial Complex I: A PET Study in Comparison with 18F-BMS-747158-02 in Rat Brain. J. Nucl. Med. [PM:24470629].
  166. Davoudi, M., Kotarsky, H., Hansson, E., and Fellman, V. (2014) Complex I Function and Supercomplex Formation Are Preserved in Liver Mitochondria Despite Progressive Complex III Deficiency. PLoS. ONE. 9:e86767- [PM:24466228].
  167. Koilkonda, R. D., Yu, H., Chou, T. H., Feuer, W. J., Ruggeri, M., Porciatti, V., Tse, D., Hauswirth, W. W., Chiodo, V., Boye, S. L., Lewin, A. S., Neuringer, M., Renner, L., and Guy, J. (2014) Safety and Effects of the Vector for the Leber Hereditary Optic Neuropathy Gene Therapy Clinical Trial. JAMA Ophthalmol. [PM:24457989].
  168. Wong, K. S., Snider, J. D., Graham, C., Greenblatt, J. F., Emili, A., Babu, M., and Houry, W. A. (2014) The MoxR ATPase RavA and Its Cofactor ViaA Interact with the NADH:Ubiquinone Oxidoreductase I in Escherichia coli. PLoS. ONE. 9:e85529- [PM:24454883].
  169. Tsukada, H., Ohba, H., Nishiyama, S., Kanazawa, M., Kakiuchi, T., and Harada, N. (2014) PET imaging of ischemia-induced impairment of mitochondrial complex I function in monkey brain. J. Cereb. Blood Flow Metab [PM:24447952].
  170. Yano, T., Rahimian, M., Aneja, K. K., Schechter, N. M., Rubin, H., and Scott, C. P. (2014) Mycobacterium tuberculosis Type-II NADH-Menaquinone Oxidoreductase (NDH-2) catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sites. Biochemistry [PM:24447297].
  171. Chouchani, T., Pell, R., Methner, C., Buonincontri, G., Murphy, P., and Krieg, T. (2014) 6 s-nitrosation of a cysteine switch on mitochondrial complex I protects from acute ischaemia-reperfusion damage and post myocardial infarction heart failure. Heart 100 Suppl 1:A3- [PM:24445456].
  172. Heikal, A., Nakatani, Y., Dunn, E., Weimar, M. R., Day, C. L., Baker, E. N., Lott, J. S., Sazanov, L. A., and Cook, G. M. (2014) Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol. Microbiol. [PM:24444429].
  173. Dolga, A. M., de, A. A., Meissner, L., Knaus, H. G., Hollerhage, M., Christophersen, P., Zischka, H., Plesnila, N., Hoglinger, G. U., and Culmsee, C. (2014) Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons. Cell Death. Dis. 5:e999- [PM:24434522].
  174. Villegas, J. M., Valle, L., Moran Vieyra, F. E., Rintoul, M. R., Borsarelli, C. D., and Rapisarda, V. A. (2014) FAD binding properties of a cytosolic version of Escherichia coli NADH dehydrogenase-2. Biochim. Biophys. Acta 1844:576-584. [PM:24418395].
  175. Grzybowska-Szatkowska, L. and Slaska, B. (2014) Mitochondrial NADH dehydrogenase polymorphisms are associated with breast cancer in Poland. J. Appl. Genet. [PM:24414975].
  176. Ray, A., Martinez, B. A., Berkowitz, L. A., Caldwell, G. A., and Caldwell, K. A. (2014) Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model. Cell Death. Dis. 5:e984- [PM:24407237].
  177. Stocks, P. A., Barton, V., Antoine, T., Biagini, G. A., Ward, S. A., and O'neill, P. M. (2014) Novel inhibitors of the Plasmodium falciparum electron transport chain. Parasitology 141:50-65. [PM:24401337].
  178. Nam, S. T., Hwang, J. H., Kim, D. H., Park, M. J., Lee, I. H., Nam, H. J., Kang, J. K., Kim, S. K., Hwang, J. S., Chung, H. K., Shong, M., Lee, C. H., and Kim, H. (2014) Role of NADH:quinone oxidoreductase-1 in the tight junctions of colonic epithelial cells. BMB. Rep. [PM:24393524].
  179. Yamada, E. S., Respondek, G., Mussner, S., de, A. A., Hollerhage, M., Depienne, C., Rastetter, A., Tarze, A., Friguet, B., Salama, M., Champy, P., Oertel, W. H., and Hoglinger, G. U. (2014) Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp. Neurol. 253C:113-125. [PM:24389273].
  180. Hughes, S. D., Kanabus, M., Anderson, G., Hargreaves, I. P., Rutherford, T., Donnell, M. O., Cross, J. H., Rahman, S., Eaton, S., and Heales, S. J. (2014) The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells. J. Neurochem. [PM:24383952].
  181. Helbig, L., Koi, L., Bruchner, K., Gurtner, K., Hess-Stumpp, H., Unterschemmann, K., Pruschy, M., Baumann, M., Yaromina, A., and Zips, D. (2014) Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation. Int. J. Radiat. Oncol. Biol. Phys. 88:159-166. [PM:24331663].
  182. Lombardo, B., Ceglia, C., Tarsitano, M., Pierucci, I., Salvatore, F., and Pastore, L. (2014) Identification of a deletion in the NDUFS4 gene using array-comparative genomic hybridization in a patient with suspected mitochondrial respiratory disease. Gene 535:376-379. [PM:24295889].

  Return to the publications page