Publications (2012)

  1. Marina, A. D., Schara, U., Pyle, A., Moller-Hartmann, C., Holinski-Feder, E., Abicht, A., Czermin, B., Lochmuller, H., Griffin, H., Santibanez-Koref, M., Chinnery, P. F., and Horvath, R. (2012) NDUFS8-related Complex I Deficiency Extends Phenotype from "PEO Plus" to Leigh Syndrome. JIMD. Rep. [PM:23430795].
  2. Tammineni, P., Anugula, C., Mohammed, F., Anjaneyulu, M., Larner, A. C., and Sepuri, N. B. (2012) The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J. Biol. Chem. [PM:23271731].
  3. Li, L., Nelson, C. J., Carrie, C., Gawryluk, R. M., Solheim, C., Gray, M. W., Whelan, J., and Millar, A. H. (2012) Subcomplexes of ancestral respiratory complex I subunits rapidly turn over in vivo as productive assembly intermediates in Arabidopsis. J. Biol. Chem. [PM:23271729].
  4. Marin, S. E., Mesterman, R., Robinson, B., Rodenburg, R. J., Smeitink, J., and Tarnopolsky, M. (2012) Leigh Syndrome Associated with Mitochondrial Complex I Deficiency Due to Novel Mutations In NDUFV1 and NDUFS2. Gene [PM:23266820].
  5. Shah, J. K., Cochrane, D. W., De, P. R., and Igamberdiev, A. U. (2012) Respiratory complex I deficiency results in low nitric oxide levels, induction of hemoglobin and upregulation of fermentation pathways. Plant Physiol Biochem. 63C:185-190. [PM:23266363].
  6. Mader, B. J., Pivtoraiko, V. N., Flippo, H. M., Klocke, B. J., Roth, K. A., Mangieri, L. R., and Shacka, J. J. (2012) Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem. Neurosci. 3:1063-1072. [PM:23259041].
  7. Caporali, L., Ghelli, A. M., Iommarini, L., Maresca, A., Valentino, M. L., La, M. C., Liguori, R., Zanna, C., Barboni, P., De, N., V, Martinuzzi, A., Rizzo, G., Tonon, C., Lodi, R., Calvaruso, M. A., Cappelletti, M., Porcelli, A. M., Achilli, A., Pala, M., Torroni, A., and Carelli, V. (2012) Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions. Biochim. Biophys. Acta [PM:23246842].
  8. Panelli, D., Lorusso, F. P., Papa, F., Panelli, P., Stella, A., Caputi, M., Sardanelli, A. M., and Papa, S. (2012) The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells. Biochim. Biophys. Acta [PM:23246602].
  9. Polster, B. M. (2012) AIF, reactive oxygen species, and neurodegeneration: A "complex" problem. Neurochem. Int. [PM:23246553].
  10. Oliveira, K. K., Kiyomoto, B. H., Rodrigues, A. D., and Tengan, C. H. (2012) Complex I spectrophotometric assay in cultured cells: detailed analysis of key factors. Anal. Biochem. [PM:23246343].
  11. Cho, J., Hur, J. H., Graniel, J., Benzer, S., and Walker, D. W. (2012) Expression of Yeast NDI1 Rescues a Drosophila Complex I Assembly Defect. PLoS. ONE. 7:e50644- [PM:23226344].
  12. Puntel, R. L., Roos, D. H., Seeger, R. L., Aschner, M., and Rocha, J. B. (2012) Organochalcogens Inhibit Mitochondrial Complexes I and II in Rat Brain: Possible Implications for Neurotoxicity. Neurotox. Res. [PM:23224748].
  13. Shitara, Y., Nakamichi, N., Norioka, M., Shima, H., Kato, Y., and Horie, T. (2012) Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria. Toxicol. Sci. [PM:23221006].
  14. Oruganty-Das, A., Ng, T., Udagawa, T., Goh, E. L., and Richter, J. D. (2012) Translational control of mitochondrial energy production mediates neuron morphogenesis. Cell Metab 16:789-800. [PM:23217258].
  15. Hikita, M., Shinzawa-Itoh, K., Moriyama, M., Ogura, T., Kihira, K., and Yoshikawa, S. (2012) Resonance Raman Spectral Properties of FMN of Bovine Heart NADH:ubiquinone Oxidoreductase Suggesting a Mechanism for the Prevention of Spontaneous Production of Reactive Oxygen Species. Biochemistry [PM:23215454].
  16. Yap, Y. W., Chen, M. J., Peng, Z. F., Manikandan, J., Ng, J. M., Llanos, R. M., Fontaine, S. L., Beart, P. M., and Cheung, N. S. (2012) Gene expression profiling of rotenone-mediated cortical neuronal death: evidence for inhibition of ubiquitin-proteasome system and autophagy-lysosomal pathway, and dysfunction of mitochondrial and calcium signalling. Neurochem. Int. [PM:23186747].
  17. Valdivieso, A. G., Clauzure, M., Marin, M. C., Taminelli, G. L., Massip Copiz, M. M., Sanchez, F., Schulman, G., Teiber, M. L., and Santa-Coloma, T. A. (2012) The Mitochondrial Complex I Activity Is Reduced in Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function. PLoS. ONE. 7:e48059- [PM:23185247].
  18. de, P. N., Cautain, B., Melguizo, A., Cortes, D., Vicente, F., Genilloud, O., Tormo, J. R., and Pelaez, F. (2012) Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I. J. Bioenerg. Biomembr. [PM:23180141].
  19. de, P. N., Cautain, B., Melguizo, A., Vicente, F., Genilloud, O., Pelaez, F., and Tormo, J. R. (2012) Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway. J. Bioenerg. Biomembr. [PM:23180140].
  20. Shi, Y., Zhao, Z., Zhu, X., Chen, K., and Zhang, Q. (2012) Expression and functional characterization of a gene associated with retinoid-interferon-induced mortality 19 (GRIM-19) from orange-spotted grouper (Epinephelus coioides). Fish. Shellfish. Immunol. [PM:23178692].
  21. Kumar, M., Kaur, P., Kumar, M., Saxena, R., Sharma, P., and Dada, R. (2012) Clinical characterization and mitochondrial DNA sequence variations in Leber hereditary optic neuropathy. Mol. Vis. 18:2687-2699. [PM:23170061].
  22. Olsson, M. G., Rosenlof, L. W., Kotarsky, H., Olofsson, T., Leanderson, T., Morgelin, M., Fellman, V., and Akerstrom, B. (2012) The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function. Antioxid. Redox. Signal. [PM:23157686].
  23. Sun, N., Fonzi, W., Chen, H., She, X., Zhang, L., Zhang, L., and Calderone, R. (2012) Azole susceptibility and transcriptome profiling in the Candida albicans mitochondrial electron transport chain complex I mutants. Antimicrob. Agents Chemother. [PM:23147730].
  24. Lin, C. S., Sharpley, M. S., Fan, W., Waymire, K. G., Sadun, A. A., Carelli, V., Ross-Cisneros, F. N., Baciu, P., Sung, E., McManus, M. J., Pan, B. X., Gil, D. W., MacGregor, G. R., and Wallace, D. C. (2012) Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc. Natl. Acad. Sci. U. S. A [PM:23129651].
  25. Gomes, F., Tahara, E. B., Busso, C., Kowaltowski, A. J., and Barros, M. H. (2012) nde1 deletion improves mitochondrial DNA maintenance in Saccharomyces cerevisiae coenzyme Q mutants. Biochem. J. [PM:23116202].
  26. Verner, Z., Skodova, I., Polakova, S., Durisova-Benkovicova, V., Horvath, A., and Lukes, J. (2012) Alternative NADH dehydrogenase (NDH2): intermembrane-space-facing counterpart of mitochondrial complex I in the procyclic Trypanosoma brucei. Parasitology1-10. [PM:23111000].
  27. Bombasaro, J. A., Guisasola, E. E., Masman, M. F., Zamora, M. A., and Rodriguez, A. M. (2012) Dynamic Function of the Alkyl Spacer of Acetogenins as Potent Inhibitors of Mitochondrial Complex I. A Molecular Dynamics Simulation Approach. Med. Chem. [PM:23106283].
  28. Torres-Bacete, J., Sinha, P. K., Sato, M., Patki, G., Kao, M. C., Matsuno-Yagi, A., and Yagi, T. (2012) Roles of Subunit NuoK (ND4L) in the Energy Transducing Mechanism of E. coli NDH-1 (NADH:quinone oxidoreductase). J. Biol. Chem. 287:42763-42772. [PM:23105119].
  29. Villegas, J. M., Torres-Bugeau, C. M., Chehin, R., Burgos, M. I., Fidelio, G. D., Rintoul, M. R., and Rapisarda, V. A. (2012) Maintenance and thermal stabilization of NADH dehydrogenase-2 conformation upon elimination of its C-terminal region. Biochimie [PM:23089137].
  30. Feng, Y., Li, W., Li, J., Wang, J., Ge, J., Xu, D., Liu, Y., Wu, K., Zeng, Q., Wu, J. W., Tian, C., Zhou, B., and Yang, M. (2012) Structural insight into the type-II mitochondrial NADH dehydrogenases. Nature [PM:23086143].
  31. Chen, Q., Zeng, Y., Wang, H., Yang, L., Yang, Y., Zhu, H., Shi, Y., Chen, W., and Hu, Y. (2012) Molecular characterization and expression analysis of NDUFS4 gene in m. longissimus dorsi of Laiwu pig (Sus scrofa). Mol. Biol. Rep. [PM:23073781].
  32. Murcha, M. W., Wang, Y., and Whelan, J. (2012) A molecular link between mitochondrial preprotein transporters and respiratory chain complexes. Plant Signal. Behav. 7: [PM:23073015].
  33. Hauser, D. N. and Hastings, T. G. (2012) Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol. Dis. [PM:23064436].
  34. Chen, H., Calderone, R., Sun, N., Wang, Y., and Li, D. (2012) Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS. Fungal. Genet. Biol. [PM:23063955].
  35. Liu, Y. Q., Cheng, X., Guo, L. X., Mao, C., Chen, Y. J., Liu, H. X., Xiao, Q. C., Jiang, S., Yao, Z. J., and Zhou, G. B. (2012) Identification of an Annonaceous Acetogenin Mimetic, AA005, as an AMPK Activator and Autophagy Inducer in Colon Cancer Cells. PLoS. ONE. 7:e47049- [PM:23056575].
  36. Donaghy, L., Kraffe, E., Le, G. N., Lambert, C., Volety, A. K., and Soudant, P. (2012) Reactive Oxygen Species in Unstimulated Hemocytes of the Pacific Oyster Crassostrea gigas: A Mitochondrial Involvement. PLoS. ONE. 7:e46594- [PM:23056359].
  37. Kurelac, I., Mackay, A., Lambros, M. B., Di, C. E., Cenacchi, G., Ceccarelli, C., Morra, I., Melcarne, A., Morandi, L., Calabrese, F. M., Attimonelli, M., Tallini, G., Reis-Filho, J. S., and Gasparre, G. (2012) Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas. Hum. Mol. Genet. [PM:23049073].
  38. Baik, R., Yu, R., Lee, Y. M., Kang, H. C., Lee, J. S., and Kim, H. D. (2012) Early cardiac evaluation in children with non-specific mitochondrial disease with isolated mitochondrial respiratory chain complex I defect. J. Paediatr. Child Health 48:1016-1020. [PM:23038991].
  39. Dieteren, C. E., Koopman, W. J., Swarts, H. G., Peters, J. G., Maczuga, P., van Gemst, J. J., Masereeuw, R., Smeitink, J. A., Nijtmans, L. G., and Willems, P. H. (2012) Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis. J. Biol. Chem. [PM:23038253].
  40. Heitz, F. D., Erb, M., Anklin, C., Robay, D., Pernet, V., and Gueven, N. (2012) Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber's Hereditary Optic Neuropathy. PLoS. ONE. 7:e45182- [PM:23028832].
  41. Cannino, G., El-Khoury, R., Pirinen, M., Hutz, B., Rustin, P., Jacobs, H. T., and Dufour, E. (2012) Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction. J. Biol. Chem. [PM:23007390].
  42. Marreiros, B. C., Batista, A. P., Duarte, A. M., and Pereira, M. M. (2012) A missing link between complex I and group 4 membrane-bound [NiFe]-hydrogenases. Biochim. Biophys. Acta [PM:23000657].
  43. Cui, Y., Zhao, S., Wu, Z., Dai, P., and Zhou, B. (2012) Mitochondrial Release of the NADH Dehydrogenase Ndi1 Induces Apoptosis in Yeast. Mol. Biol. Cell [PM:22993213].
  44. Wang, Q., Fristedt, R., Yu, X., Chen, Z., Liu, H., Lee, Y., Guo, H., Merchant, S. S., and Lin, C. (2012) The gamma-carbonic anhydrase subcomplex of mitochondrial complex I is essential for development and important for photomorphogenesis of Arabidopsis. Plant Physiol [PM:22991283].
  45. Verkhovskaya, M. and Bloch, D. A. (2012) Energy-converting respiratory Complex I: On the way to the molecular mechanism of the proton pump. Int. J. Biochem. Cell Biol. [PM:22982742].
  46. Heide, H., Bleier, L., Steger, M., Ackermann, J., Drose, S., Schwamb, B., Zornig, M., Reichert, A. S., Koch, I., Wittig, I., and Brandt, U. (2012) Complexome Profiling Identifies TMEM126B as a Component of the Mitochondrial Complex I Assembly Complex. Cell Metab [PM:22982022].
  47. Fassone, E. and Rahman, S. (2012) Complex I deficiency: clinical features, biochemistry and molecular genetics. J. Med. Genet. 49:578-590. [PM:22972949].
  48. Garvin, M. R., Bielawski, J. P., and Gharrett, A. J. (2012) Correction: Positive Darwinian Selection in the Piston That Powers Proton Pumps in Complex I of the Mitochondria of Pacific Salmon. PLoS. ONE. 7: [PM:22970091].
  49. Perfeito, R., Cunha-Oliveira, T., and Rego, A. C. (2012) Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse. Free Radic. Biol. Med. [PM:22967820].
  50. Py, B., Gerez, C., Angelini, S., Planel, R., Vinella, D., Loiseau, L., Talla, E., Brochier-Armanet, C., Garcia, S. R., Latour, J. M., Ollagnier-de, C. S., Fontecave, M., and Barras, F. (2012) Molecular organization, biochemical function, cellular role and evolution of NfuA, an atypical Fe-S carrier. Mol. Microbiol. 86:155-171. [PM:22966982].
  51. Duarte, M. and Videira, A. (2012) Defective valyl tRNA synthetase hampers the mitochondrial respiratory chain in Neurospora crassa. Biochem. J. [PM:22957697].
  52. Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A. D., and Maher, M. J. (2012) The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. Proc. Natl. Acad. Sci. U. S. A 109:15247-15252. [PM:22949654].
  53. Ma, Y. Y., Wu, T. F., Liu, Y. P., Wang, Q., Li, X. Y., Zhang, Y., Song, J. Q., Wang, Y. J., and Yang, Y. L. (2012) Mitochondrial respiratory chain enzyme assay and DNA analysis in peripheral blood leukocytes for the etiological study of Chinese children with Leigh syndrome due to complex I deficiency. Mitochondrial. DNA [PM:22947169].
  54. Lin, T. K., Cheng, C. H., Chen, S. D., Liou, C. W., Huang, C. R., and Chuang, Y. C. (2012) Mitochondrial Dysfunction and Oxidative Stress Promote Apoptotic Cell Death in the Striatum via Cytochrome c/Caspase-3 Signaling Cascade Following Chronic Rotenone Intoxication in Rats. Int. J. Mol. Sci. 13:8722-8739. [PM:22942730].
  55. Quintana, A., Morgan, P. G., Kruse, S. E., Palmiter, R. D., and Sedensky, M. M. (2012) Altered anesthetic sensitivity of mice lacking ndufs4, a subunit of mitochondrial complex I. PLoS. ONE. 7:e42904- [PM:22912761].
  56. Irwin, M. H., Parameshwaran, K., and Pinkert, C. A. (2012) Mouse models of mitochondrial complex I dysfunction. Int. J. Biochem. Cell Biol. [PM:22903069].
  57. Balsa, E., Marco, R., Perales-Clemente, E., Szklarczyk, R., Calvo, E., Landazuri, M. O., and Enriquez, J. A. (2012) NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain. Cell Metab [PM:22902835].
  58. Ryan, K., Backos, D. S., Reigan, P., and Patel, M. (2012) Post-translational oxidative modification and inactivation of mitochondrial complex I in epileptogenesis. J. Neurosci. 32:11250-11258. [PM:22895709].
  59. Hofle, G., Gerth, K., Reichenbach, H., Kunze, B., Sasse, F., Forche, E., and Prusov, E. V. (2012) Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex i inhibitor. Chemistry. 18:11362-11370. [PM:22890974].
  60. Panelli, D., Lorusso, F. P., Trentadue, R., Stella, A., Sardanelli, A. M., and Papa, S. (2012) The hUPF1-NMD factor controls the cellular transcript levels of different genes of complex I of the respiratory chain. Biochimie [PM:22889941].
  61. Oxler, E. M., Dolga, A., and Culmsee, C. (2012) AIF depletion provides neuroprotection through a preconditioning effect. Apoptosis. [PM:22865232].
  62. Ueda, M., Kuniyoshi, T., Yamamoto, H., Sugimoto, K., Ishizaki, K., Kohchi, T., Nishimura, Y., and Shikanai, T. (2012) Compositionand physiological function of the chloroplast NADH dehydrogenase-like complex in Marchantia polymorpha. Plant J. [PM:22862786].
  63. Ramonet, D., Perier, C., Recasens, A., Dehay, B., Bove, J., Costa, V., Scorrano, L., and Vila, M. (2012) Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency. Cell Death. Differ. [PM:22858546].
  64. Kensche, P. R., Duarte, I., and Huynen, M. A. (2012) A three-dimensional topology of complex I inferred from evolutionary correlations. BMC. Struct. Biol. 12:19- [PM:22857522].
  65. Roberts, P. G. and Hirst, J. (2012) The Deactive Form of Respiratory Complex I from Mammalian Mitochondria is a Na+/H+ Antiporter. J. Biol. Chem. [PM:22854968].
  66. Swarnkar, S., Singh, S., Goswami, P., Mathur, R., Patro, I. K., and Nath, C. (2012) Astrocyte Activation: A Key Step in Rotenone Induced Cytotoxicity and DNA Damage. Neurochem. Res. [PM:22846965].
  67. Ogura, M., Yamaki, J., Homma, M. K., and Homma, Y. (2012) Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components. Biochem. J. [PM:22823520].
  68. Puurand, M., Peet, N., Piirsoo, A., Peetsalu, M., Soplepmann, J., Sirotkina, M., Peetsalu, A., Hemminki, A., and Seppet, E. (2012) Deficiency of the complex I of the mitochondrial respiratory chain but improved adenylate control over succinate-dependent respiration are human gastric cancer-specific phenomena. Mol. Cell Biochem. [PM:22821176].
  69. Hoefs, S. J., Rodenburg, R. J., Smeitink, J. A., and Van den Heuvel, L. P. (2012) Molecular base of biochemical complex I deficiency. Mitochondrion. [PM:22820119].
  70. Lecler, R., Vigeolas, H., Emonds-Alt, B., Cardol, P., and Remacle, C. (2012) Characterization of an internal type-II NADH dehydrogenase from Chlamydomonas reinhardtii mitochondria. Curr. Genet. 58:205-216. [PM:22814755].
  71. Pravdic, D., Hirata, N., Barber, L., Sedlic, F., Bosnjak, Z. J., and Bienengraeber, M. (2012) Complex I and ATP synthase mediate membrane depolarization and matrix acidification by isoflurane in mitochondria. Eur. J. Pharmacol. 690:149-157. [PM:22796646].
  72. Vejandla, H., Hollander, J. M., Kothur, A., and Brock, R. W. (2012) C-Peptide Reduces Mitochondrial Superoxide Generation by Restoring Complex I Activity in High Glucose-Exposed Renal Microvascular Endothelial Cells. ISRN. Endocrinol. 2012:162802- [PM:22778984].
  73. Hirsch, A., Hahn, D., Kempna, P., Hofer, G., Nuoffer, J. M., Mullis, P. E., and Fluck, C. E. (2012) Metformin Inhibits Human Androgen Production by Regulating Steroidogenic Enzymes HSD3B2 and CYP17A1 and Complex I Activity of the Respiratory Chain. Endocrinology [PM:22778212].
  74. Yu, H., Ozdemir, S. S., Koilkonda, R. D., Chou, T. H., Porciatti, V., Chiodo, V., Boye, S. L., Hauswirth, W. W., Lewin, A. S., and Guy, J. (2012) Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice. Mol. Vis. 18:1668-1683. [PM:22773905].
  75. Wang, Y., Carrie, C., Giraud, E., Elhafez, D., Narsai, R., Duncan, O., Whelan, J., and Murcha, M. W. (2012) Dual Location of the Mitochondrial Preprotein Transporters B14.7 and Tim23-2 in Complex I and the TIM17:23 Complex in Arabidopsis Links Mitochondrial Activity and Biogenesis. Plant Cell [PM:22730406].
  76. Drose, S. and Brandt, U. (2012) Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. Adv. Exp. Med. Biol. 748:145-169. [PM:22729857].
  77. Lenaz, G. and Genova, M. L. (2012) Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation. Adv. Exp. Med. Biol. 748:107-144. [PM:22729856].
  78. Lee, J. E., Park, J. H., Shin, I. C., and Koh, H. C. (2012) Reactive oxygen species regulated mitochondria-mediated apoptosis in PC12 cells exposed to chlorpyrifos. Toxicol. Appl. Pharmacol. [PM:22714038].
  79. Xiao, F., Li, Y., Dai, L., Deng, Y., Zou, Y., Li, P., Yang, Y., and Zhong, C. (2012) Hexavalent chromium targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent caspase-3 activation in L-02 hepatocytes. Int. J. Mol. Med. 30:629-635. [PM:22710416].
  80. Sonia, A. M., Chaterjee, P., Anand, K., Ambasta, R. K., and Kumar, P. (2012) Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. Neuroscience [PM:22710069].
  81. Sousa, P. M., Videira, M. A., Bohn, A., Hood, B. L., Conrads, T. P., Goulao, L. F., and Melo, A. M. (2012) The aerobic respiratory chain of Escherichia coli: from genes to supercomplexes. Microbiology [PM:22700653].
  82. Verkhovsky, M. I., Bogachev, A. V., Pivtsov, A. V., Bertsova, Y. V., Fedin, M. V., Bloch, D. A., and Kulik, L. V. (2012) Sodium-Dependent Movement of Covalently Bound FMN Residue(s) in Na+-Translocating NADH:Quinone Oxidoreductase. Biochemistry [PM:22697411].
  83. Meyer, K. J., Singh, A. J., Cameron, A., Tan, A. S., Leahy, D. C., O'Sullivan, D., Joshi, P., La Flamme, A. C., Northcote, P. T., Berridge, M. V., and Miller, J. H. (2012) Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. Mar. Drugs 10:900-917. [PM:22690150].
  84. Lunin, V. Y., Lunina, N. L., Casutt, M. S., Knoops, K., Schaffitzel, C., Steuber, J., Fritz, G., and Baumstark, M. W. (2012) Low-resolution structure determination of Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio cholerae by ab initio phasing and electron microscopy. Acta Crystallogr. D. Biol. Crystallogr. 68:724-731. [PM:22683795].
  85. Chadderton, N., Palfi, A., Millington-Ward, S., Gobbo, O., Overlack, N., Carrigan, M., O'reilly, M., Campbell, M., Ehrhardt, C., Wolfrum, U., Humphries, P., Kenna, P. F., and Jane, F. G. (2012) Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy. Eur. J. Hum. Genet. [PM:22669418].
  86. Juarez, O., Neehaul, Y., Turk, E., Chahubon, N., Demicco, J. M., Hellwig, P., and Barquera, B. (2012) The role of Glycine Residues 140 and 141 of Subunit B in the Functional Ubiquinone Binding Site of the Na+ Pumping NADH:Quinone Oxidoreductase from Vibrio cholerae. J. Biol. Chem. [PM:22645140].
  87. Koene, S., Rodenburg, R. J., van der Knaap, M. S., Willemsen, M. A., Sperl, W., Laugel, V., Ostergaard, E., Tarnopolsky, M., Martin, M. A., Nesbitt, V., Fletcher, J., Edvardson, S., Procaccio, V., Slama, A., Van den Heuvel, L. P., and Smeitink, J. A. (2012) Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases. J. Inherit. Metab Dis. [PM:22644603].
  88. Kang, P. T., Zhang, L., Chen, C. L., Green-Church, K. B., and Chen, Y. R. (2012) Protein thiyl radical mediates S-glutathionylation of complex I. Free Radic. Biol. Med. [PM:22634394].
  89. Kimura, R., Ma, L. Y., Wu, C., Turner, D., Shen, J. X., Ellsworth, K., Wakui, M., Maalouf, M., and Wu, J. (2012) Acute Exposure to the Mitochondrial Complex I Toxin Rotenone Impairs Synaptic Long-Term Potentiation in Rat Hippocampal Slices. CNS. Neurosci. Ther. [PM:22613619].
  90. Lustgarten, M. S., Bhattacharya, A., Muller, F. L., Jang, Y. C., Shimizu, T., Shirasawa, T., Richardson, A., and Van, R. H. (2012) Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem. Biophys. Res. Commun. [PM:22613204].
  91. Shi, H., Gao, J., Pei, H., Liu, R., Hu, W. K., Wan, X., Li, T., and Li, B. (2012) AAV-mediated gene delivery of the human ND4 complex I subunit in rabbit eyes. Clin. Experiment. Ophthalmol. [PM:22612072].
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