Publications (2009)

  1. Morais, V. A., Verstreken, P., Roethig, A., Smet, J., Snellinx, A., Vanbrabant, M., Haddad, D., Frezza, C., Mandemakers, W., Vogt-Weisenhorn, D., Van, C. R., Wurst, W., Scorrano, L., and De, S. B. (2009) Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol. Med. 1:99-111. [PM:20049710].
  2. Caro, P., Gomez, J., Sanchez, I., Naudi, A., Ayala, V., Lopez-Torres, M., Pamplona, R., and Barja, G. (2009) Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria. Rejuvenation. Res. 12:421-434. [PM:20041736].
  3. Koilkonda, R. D., Hauswirth, W. W., and Guy, J. (2009) Efficient expression of self-complementary AAV in ganglion cells of the ex vivo primate retina. Mol. Vis. 15:2796-2802. [PM:20019878].
  4. Ghelli, A., Porcelli, A. M., Zanna, C., Vidoni, S., Mattioli, S., Barbieri, A., Iommarini, L., Pala, M., Achilli, A., Torroni, A., Rugolo, M., and Carelli, V. (2009) The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity. PLoS. ONE. 4:e7922- [PM:19936068].
  5. Xiong, N., Huang, J., Zhang, Z., Zhang, Z., Xiong, J., Liu, X., Jia, M., Wang, F., Chen, C., Cao, X., Liang, Z., Sun, S., Lin, Z., and Wang, T. (2009) Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease. PLoS. ONE. 4:e7878- [PM:19924288].
  6. Liu, Y., Morgan, J. B., Coothankandaswamy, V., Liu, R., Jekabsons, M. B., Mahdi, F., Nagle, D. G., and Zhou, Y. D. (2009) The Caulerpa Pigment Caulerpin Inhibits HIF-1 Activation and Mitochondrial Respiration. J. Nat. Prod.72:2104-2109. [PM:19921787].
  7. Navarro, A. and Boveris, A. (2009) Brain mitochondrial dysfunction and oxidative damage in Parkinson's disease. J. Bioenerg. Biomembr. 41:517-521. [PM:19915964].
  8. Marella, M., Seo, B. B., Yagi, T., and Matsuno-Yagi, A. (2009) Parkinson's disease and mitochondrial complex I: a perspective on the Ndi1 therapy. J. Bioenerg. Biomembr. 41:493-497. [PM:19904590].
  9. Papa, S., Sardanelli, A. M., Capitanio, N., and Piccoli, C. (2009) Mitochondrial respiratory dysfunction and mutations in mitochondrial DNA in PINK1 familial Parkinsonism. J. Bioenerg. Biomembr. 41:509-516. [PM:19904588].
  10. Birrell, J. A., Yakovlev, G., and Hirst, J. (2009) Reactions of the Flavin Mononucleotide in Complex I: A Combined Mechanism Describes NADH Oxidation Coupled to the Reduction of APAD(+), Ferricyanide, or Molecular Oxygen. Biochemistry38:12005-12013. [PM:19899808].
  11. Taurines, R., Thome, J., Duvigneau, J. C., Forbes-Robertson, S., Yang, L., Klampfl, K., Romanos, J., Muller, S., Gerlach, M., and Mehler-Wex, C. (2009) Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. Eur. Child Adolesc. Psychiatry [PM:19894076].
  12. Wang, M. J. and Lin, S. (2009) A region within the 5'-untranslated region of hypoxia-inducible factor-1alpha mRNA mediates its turnover in lung adenocarcinoma cells. J. Biol. Chem. 284:36500-36510. [PM:19887373].
  13. Kim, H. J., Song, J. Y., Park, H. J., Park, H. K., Yun, D. H., and Chung, J. H. (2009) Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells. Korean J. Physiol Pharmacol. 13:281-285. [PM:19885011].
  14. Galkin, A., Abramov, A. Y., Frakich, N., Duchen, M. R., and Moncada, S. (2009) Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury? J. Biol. Chem. 284:36055-36061. [PM:19861410].
  15. Mao, S. C., Liu, Y., Morgan, J. B., Jekabsons, M. B., Zhou, Y. D., and Nagle, D. G. (2009) Lipophilic 2,5-Disubstituted Pyrroles from the Marine Sponge Mycale sp. Inhibit Mitochondrial Respiration and HIF-1 Activation. J. Nat. Prod.72:1927-1936. [PM:19845338].
  16. Valls-Belles, V., Torres, C., Muniz, P., and Codoner-Franch, P. (2009) Effect of beer consumption on levels of complex I and complex IV liver and heart mitochondrial enzymes and coenzymes Q9 and Q10 in adriamycin-treated rats. Eur. J. Nutr. [PM:19841853].
  17. Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y. C., Maita, H., Maita, C., Ariga, H., and Iguchi-Ariga, S. M. (2009) DJ-1 binds to mitochondrial complex I and maintains its activity. Biochem. Biophys. Res. Commun.390:667-672. [PM:19822128].
  18. Zoccarato, F., Cavallini, L., and Alexandre, A. (2009) Succinate is the controller of O2-/H2O2 release at mitochondrial complex I : negative modulation by malate, positive by cyanide. J. Bioenerg. Biomembr. 41:387-393. [PM:19821037].
  19. Shiryaeva, A., Arkadyeva, A., Emelyanova, L., Sakuta, G., and Morozov, V. (2009) Superoxide anion production by the mitochondrial respiratory chain of hepatocytes of rats with experimental toxic hepatitis. J. Bioenerg. Biomembr. 41:379-385. [PM:19821036].
  20. Torres-Bacete, J., Sinha, P. K., Castro-Guerrero, N., Matsuno-Yagi, A., and Yagi, T. (2009) Features of subunit NuoM (ND4) in Escherichia coli NDH-1: Topology and implication of conserved Glu144 for coupling site 1. J. Biol. Chem. 284:33062-33069. [PM:19815558].
  21. Keeney, P. M., Dunham, L. D., Quigley, C. K., Morton, S. L., Bergquist, K. E., and Bennett, J. P., Jr. (2009) Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp. Neurol. 220:374-382. [PM:19815014].
  22. Arduino, D. M., Esteves, A. R., Oliveira, C. R., and Cardoso, S. M. (2009) Mitochondrial Metabolism Modulation: A New Therapeutic Approach for Parkinson's Disease. CNS. Neurol. Disord. Drug Targets. [PM:19811444].
  23. Chan, S. Y., Zhang, Y. Y., Hemann, C., Mahoney, C. E., Zweier, J. L., and Loscalzo, J. (2009) MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 10:273-284. [PM:19808020].
  24. Zid, B. M., Rogers, A. N., Katewa, S. D., Vargas, M. A., Kolipinski, M. C., Lu, T. A., Benzer, S., and Kapahi, P. (2009) 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell 139:149-160. [PM:19804760].
  25. Koshikawa, N., Hayashi, J. I., Nakagawara, A., and Takenaga, K. (2009) ROS-generating mitochondrial DNA mutation upregulates hypoxia-inducible factor-1alpha gene transcription via PI3K-Akt/PKC/HDAC pathway. J. Biol. Chem. 284:33185-33194. [PM:19801684].
  26. Lartigue, L., Kushnareva, Y., Seong, Y., Lin, H., Faustin, B., and Newmeyer, D. D. (2009) Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, not Cytotoxic Protein Release. Mol. Biol. Cell 20:4871-4884. [PM:19793916].
  27. Ben-Shachar, D. (2009) The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia. J. Neural Transm. 116:1383-1396. [PM:19784753].
  28. Arthur, C. R., Morton, S. L., Dunham, L. D., Keeney, P. M., and Bennett, J. P., Jr. (2009) Parkinson's Disease Brain Mitochondria Have Impaired Respirasome Assembly, Age-Related Increases in Distribution of Oxidative Damage to mtDNA and No Differences in Heteroplasmic mtDNA Mutation Abundance. Mol. Neurodegener. 4:37- [PM:19775436].
  29. Naoi, M., Maruyama, W., Yi, H., Inaba, K., Akao, Y., and Shamoto-Nagai, M. (2009) Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. J. Neural Transm. 116:1371-1381. [PM:19763773].
  30. Kulawiec, M., Owens, K. M., and Singh, K. K. (2009) mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice. J. Hum. Genet. 54:647-654. [PM:19763141].
  31. Sheftel, A. D., Stehling, O., Pierik, A. J., Netz, D. J., Kerscher, S., Elsasser, H. P., Wittig, I., Balk, J., Brandt, U., and Lill, R. (2009) Human Ind1, an iron-sulfur cluster assembly factor for respiratory complex I. Mol. Cell Biol. 29:6059-6073. [PM:19752196].
  32. Yeh, S. T., Lee, H. L., Aune, S. E., Chen, C. L., Chen, Y. R., and Angelos, M. G. (2009) Preservation of mitochondrial function with cardiopulmonary resuscitation in prolonged cardiac arrest in rats. J. Mol. Cell Cardiol. 47:789-797. [PM:19751739].
  33. Copeland, J. M., Cho, J., Lo, T., Jr., Hur, J. H., Bahadorani, S., Arabyan, T., Rabie, J., Soh, J., and Walker, D. W. (2009) Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain. Curr. Biol. 19:1591-1598. [PM:19747824].
  34. Hosamani, R. and Muralidhara (2009) Neuroprotective efficacy of Bacopa monnieri against rotenone induced oxidative stress and neurotoxicity in Drosophila melanogaster. Neurotoxicology 30:977-985. [PM:19744517].
  35. Ng, C. H., Mok, S. Z., Koh, C., Ouyang, X., Fivaz, M. L., Tan, E. K., Dawson, V. L., Dawson, T. M., Yu, F., and Lim, K. L. (2009) Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila. J. Neurosci. 29:11257-11262. [PM:19741132].
  36. Dezfulian, C., Shiva, S., Alekseyenko, A., Pendyal, A., Beiser, D. G., Munasinghe, J. P., Anderson, S. A., Chesley, C. F., Vanden Hoek, T. L., and Gladwin, M. T. (2009) Nitrite Therapy After Cardiac Arrest Reduces Reactive Oxygen Species Generation, Improves Cardiac and Neurological Function, and Enhances Survival via Reversible Inhibition of Mitochondrial Complex I. Circulation 120:897-905. [PM:19704094].
  37. Willems, P. H., Smeitink, J. A., and Koopman, W. J. (2009) Mitochondrial dynamics in human NADH:ubiquinone oxidoreductase deficiency. Int. J. Biochem. Cell Biol. 41:1773-1782. [PM:19703648].
  38. Mogi, T. and Kita, K. (2009) Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics. Cell Mol. Life Sci. 66:3821-3826. [PM:19701717].
  39. Juarez, O., Athearn, K., Gillespie, P., and Barquera, B. (2009) Acid residues in the transmembrane helices of the Na+-pumping NADH:quinone oxidoreductase (Na+-NQR) from Vibrio cholerae involved in sodium translocation. Biochemistry 48:9516-9524. [PM:19694431].
  40. Wessels, H. J., Vogel, R. O., Van den Heuvel, L., Smeitink, J. A., Rodenburg, R. J., Nijtmans, L. G., and Farhoud, M. H. (2009) LC-MS/MS as an alternative for SDS-PAGE in blue native analysis of protein complexes. Proteomics. 9:4221-4228. [PM:19688755].
  41. Hollerhage, M., Matusch, A., Champy, P., Lombes, A., Ruberg, M., Oertel, W. H., and Hoglinger, G. U. (2009) Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. Exp. Neurol. 220:133-142. [PM:19682988].
  42. Pan, T., Rawal, P., Wu, Y., Xie, W., Jankovic, J., and Le, W. (2009) Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience 164:541-551. [PM:19682553].
  43. Carroll, J., Fearnley, I. M., Wang, Q., and Walker, J. E. (2009) Measurement of the molecular masses of hydrophilic and hydrophobic subunits of adenosine triphosphate synthase and complex I in a single experiment. Anal. Biochem. 395:249-255. [PM:19679095].
  44. Falk, M. J., Rosenjack, J. R., Polyak, E., Suthammarak, W., Chen, Z., Morgan, P. G., and Sedensky, M. M. (2009) Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. PLoS. ONE. 4:e6607- [PM:19672299].
  45. Kokaze, A., Ishikawa, M., Matsunaga, N., Karita, K., Yoshida, M., Ohtsu, T., Shirasawa, T., Sekii, H., Ito, T., Kawamoto, T., and Takashima, Y. (2009) NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modulates the Effects of Coffee Consumption on the Risk of Hypertension in Middle-Aged Japanese Men. J. Epidemiol. 19:231-236. [PM:19667492].
  46. Ota, S., Horigome, K., Ishii, T., Nakai, M., Hayashi, K., Kawamura, T., Kishino, A., Taiji, M., and Kimura, T. (2009) Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism. Biochem. Biophys. Res. Commun. 388:311-316. [PM:19664596].
  47. Barber-Singh, J., Seo, B. B., Nakamaru-Ogiso, E., Lau, Y. S., Matsuno-Yagi, A., and Yagi, T. (2009) Neuroprotective Effect of Long-term NDI1 Gene Expression in a Chronic Mouse Model of Parkinson Disorder. Rejuvenation. Res. 12:259-267. [PM:19653878].
  48. Pepelina, T. Y., Chertkova, R. V., Ostroverkhova, T. V., Dolgikh, D. A., Kirpichnikov, M. P., Grivennikova, V. G., and Vinogradov, A. D. (2009) Site-directed mutagenesis of cytochrome c: reactions with respiratory chain components and superoxide radical. Biochemistry (Mosc. ) 74:625-632. [PM:19645667].
  49. Berrisford, J. M. and Sazanov, L. A. (2009) Structural basis for the mechanism of respiratory complex I. J. Biol. Chem. 284:29773-29783. [PM:19635800].
  50. Cesar, C. J., Kowaltowski, A. J., Mendonca, M. A., de Oliveira, T. C., Gadelha, F. R., and Zingales, B. (2009) Mitochondrial bioenergetics and redox state are unaltered in Trypanosoma cruzi isolates with compromised mitochondrial complex I subunit genes. J. Bioenerg. Biomembr. 41:299-308. [PM:19618257].
  51. Lim, B. C., Park, J. D., Hwang, H., Kim, K. J., Hwang, Y. S., Chae, J. H., Cheon, J. E., Kim, I. O., Lee, R., and Moon, H. K. (2009) Mutations in ND subunits of complex I are an important genetic cause of childhood mitochondrial encephalopathies. J. Child Neurol. 24:828-832. [PM:19617458].
  52. Belaiche, C., Holt, A., and Saada, A. (2009) Nonylphenol Ethoxylate Plastic Additives Inhibit Mitochondrial Respiratory Chain Complex I. Clin. Chem. 55:1883-1884. [PM:19617286].
  53. Maliniemi, P., Kervinen, M., and Hassinen, I. E. (2009) Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NUOH. Mitochondrion. 9:394-401. [PM:19616643].
  54. Alam, M., Danysz, W., Schmidt, W. J., and Dekundy, A. (2009) Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. Toxicol. Appl. Pharmacol. 240:198-207. [PM:19616571].
  55. Tantucci, M., Mariucci, G., Taha, E., Spaccatini, C., Tozzi, A., Luchetti, E., Calabresi, P., and Ambrosini, M. V. (2009) Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment. Neuroscience 163:735-740. [PM:19580850].
  56. Kiebish, M. A., Han, X., Cheng, H., and Seyfried, T. N. (2009) In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumours. ASN. Neuro. 1: [PM:19570033].
  57. Victor, V. M., Rocha, M., Banuls, C., Sanchez-Serrano, M., Sola, E., Gomez, M., and Hernandez-Mijares, A. (2009) Mitochondrial Complex I Impairment in Leukocytes from Polycystic Ovary Syndrome Patients with Insulin Resistance. J. Clin. Endocrinol. Metab 94:3505-3512. [PM:19567514].
  58. Liu, H., Liu, L., Liu, K., Bizargity, P., Hancock, W. W., and Visner, G. A. (2009) Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression. J. Immunol. 183:1022-1031. [PM:19564344].
  59. Mogi, T., Murase, Y., Mori, M., Shiomi, K., Omura, S., Paranagama, M. P., and Kita, K. (2009) Polymyxin B identified as an inhibitor of alternative NADH dehydrogenase and malate: quinone oxidoreductase from the Gram-positive bacterium Mycobacterium smegmatis. J. Biochem. 146:491-499. [PM:19564154].
  60. Henderson, J. R., Swalwell, H., Boulton, S., Manning, P., McNeil, C. P., and Birch-Machin, M. A. (2009) Direct, real-time monitoring of superoxide generation in isolated mitochondria. Free Radic. Res. 43:296-802. [PM:19562601].
  61. Gerards, M., Sluiter, W., Van Den Bosch, B. J., de, W. E., Calis, C. M., Frentzen, M., Akbari, H., Schoonderwoerd, K., Scholte, H. R., Jongbloed, R. J., Hendrickx, A. T., De Coo, I. F., and Smeets, H. J. (2009) Defective complex I assembly due to C20orf7 mutations as a new cause of Leigh syndrome. J. Med. Genet. [PM:19542079].
  62. Mallajosyula, J. K., Chinta, S. J., Rajagopalan, S., Nicholls, D. G., and Andersen, J. K. (2009) Metabolic Control Analysis in a Cellular Model of Elevated MAO-B: Relevance to Parkinson's Disease. Neurotox. Res. 16:186-193. [PM:19526285].
  63. Janssen, R. J., Distelmaier, F., Smeets, R., Wijnhoven, T., Ostergaard, E., Jaspers, N. G., Raams, A., Kemp, S., Rodenburg, R. J., Willems, P. H., Van den Heuvel, L. P., Smeitink, J. A., and Nijtmans, L. G. (2009) Contiguous gene deletion of ELOVL7, ERCC8, and NDUFAF2 in a patient with a fatal multisystem disorder. Hum. Mol. Genet. 18:3365-3374. [PM:19525295].
  64. Gonzalez, R., Ferrin, G., Hidalgo, A. B., Ranchal, I., Lopez-Cillero, P., Santos-Gonzalez, M., Lopez-Lluch, G., Briceno, J., Gomez, M. A., Poyato, A., Villalba, J. M., Navas, P., de la Mata, M., and Muntane, J. (2009) N-acetylcysteine, coenzyme Q(10) and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes. Chem. Biol. Interact. 181:95-106. [PM:19523936].
  65. Werner, K. G., Morel, C. F., Kirton, A., Benseler, S. M., Shoffner, J. M., Addis, J. B., Robinson, B. H., Burrowes, D. M., Blaser, S. I., Epstein, L. G., and Feigenbaum, A. S. (2009) Rolandic mitochondrial encephalomyelopathy and MT-ND3 mutations. Pediatr. Neurol. 41:27-33. [PM:19520270].
  66. Long, J., Luo, C., Ma, J., Mo, X., Sun, L., Zang, W., and Liu, J. (2009) Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci. 85:276-280. [PM:19520091].
  67. Rustin, P. and Jacobs, H. T. (2009) Respiratory chain alternative enzymes as tools to better understand and counteract respiratory chain deficiencies in human cells and animals. Physiol Plant 137:362-370. [PM:19508504].
  68. Wittekindt, C., Schwarz, M., Friedrich, T., and Koslowski, T. (2009) Aromatic amino acids as stepping stones in charge transfer in respiratory complex I: an unusual mechanism deduced from atomistic theory and bioinformatics. J. Am. Chem. Soc. 131:8134-8140. [PM:19507904].
  69. Pienaar, I. S., Schallert, T., Hattingh, S., and Daniels, W. M. (2009) Behavioral and quantitative mitochondrial proteome analyses of the effects of simvastatin: implications for models of neural degeneration. J. Neural Transm. 116:791-806. [PM:19504041].
  70. Bogachev, A. V., Bloch, D. A., Bertsova, Y. V., and Verkhovsky, M. I. (2009) Redox Properties of the Prosthetic Groups of Na+-Translocating NADH:Quinone Oxidoreductase. 2. Study of the Enzyme by Optical Spectroscopy. Biochemistry 48:6299-6304. [PM:19496622].
  71. Bogachev, A. V., Kulik, L. V., Bloch, D. A., Bertsova, Y. V., Fadeeva, M. S., and Verkhovsky, M. I. (2009) Redox Properties of the Prosthetic Groups of Na+-Translocating NADH:Quinone Oxidoreductase. 1. Electron Paramagnetic Resonance Study of the Enzyme. Biochemistry 48:6291-6298. [PM:19496621].
  72. Ullrich, C. and Humpel, C. (2009) Rotenone Induces Cell Death of Cholinergic Neurons in an Organotypic Co-Culture Brain Slice Model. Neurochem. Res. [PM:19495971].
  73. Sapag, A., Gonzalez-Martinez, G., Lobos-Gonzalez, L., Encina, G., Tampier, L., Israel, Y., and Quintanilla, M. E. (2009) Polymorphisms in mitochondrial genes encoding complex I subunits are maternal factors of voluntary alcohol consumption in the rat. Pharmacogenet. Genomics 19:528-537. [PM:19494790].
  74. Saada, A., Vogel, R. O., Hoefs, S. J., van den Brand, M. A., Wessels, H. J., Willems, P. H., Venselaar, H., Shaag, A., Barghuti, F., Reish, O., Shohat, M., Huynen, M. A., Smeitink, J. A., Van den Heuvel, L. P., and Nijtmans, L. G. (2009) Mutations in NDUFAF3 (C3ORF60), Encoding an NDUFAF4 (C6ORF66)-Interacting Complex I Assembly Protein, Cause Fatal Neonatal Mitochondrial Disease. Am. J. Hum. Genet. 84:718-727. [PM:19463981].
  75. Ingraham, C. A., Burwell, L. S., Skalska, J., Brookes, P. S., Howell, R. L., Sheu, S. S., and Pinkert, C. A. (2009) NDUFS4: Creation of a Mouse Model Mimicking a Complex I Disorder. Mitochondrion. 9:204-210. [PM:19460290].
  76. Bridges, H. R., Grgic, L., Harbour, M. E., and Hirst, J. (2009) The respiratory complexes I from the mitochondria of two Pichia species. Biochem. J. 422:151-159. [PM:19459785].
  77. Brenner-Lavie, H., Klein, E., and Ben-Shachar, D. (2009) Mitochondrial complex I as a novel target for intraneuronal DA: modulation of respiration in intact cells. Biochem. Pharmacol. 78:85-95. [PM:19447227].
  78. Couch, V. A., Medvedev, E. S., and Stuchebrukhov, A. A. (2009) Electrostatics of the FeS clusters in respiratory complex I. Biochim. Biophys. Acta 1787:1266-1271. [PM:19445896].
  79. Chinta, S. J., Rane, A., Yadava, N., Andersen, J. K., Nicholls, D. G., and Polster, B. M. (2009) Reactive oxygen species regulation by AIF-and complex I-depleted brain mitochondria. Free Radic. Biol. Med. 46:939-947. [PM:19280713].
  80. Zafar, M. N., Tasca, F., Gorton, L., Patridge, E. V., Ferry, J. G., and Noll, G. (2009) Tryptophan repressor-binding proteins from Escherichia coli and Archaeoglobus fulgidus as new catalysts for 1,4-dihydronicotinamide adenine dinucleotide-dependent amperometric biosensors and biofuel cells. Anal. Chem. 81:4082-4088. [PM:19438267].
  81. Plecita-Hlavata, L., Jezek, J., and Jezek, P. (2009) Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. Int. J. Biochem. Cell Biol. 41:1697-1707. [PM:19433311].
  82. Liu, G., Zhang, C., Yin, J., Li, X., Cheng, F., Li, Y., Yang, H., Ueda, K., Chan, P., and Yu, S. (2009) alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci. Lett. 454:187-192. [PM:19429081].
  83. Hirschey, M. D., Shimazu, T., Huang, J. Y., and Verdin, E. (2009) Acetylation of mitochondrial proteins. Methods Enzymol. 457:137-147. [PM:19426866].
  84. Choi, D. Y., Liu, M., Hunter, R. L., Cass, W. A., Pandya, J. D., Sullivan, P. G., Shin, E. J., Kim, H. C., Gash, D. M., and Bing, G. (2009) Striatal neuroinflammation promotes parkinsonism in rats. PLoS. ONE. 4:e5482- [PM:19424495].
  85. Belcastro, V., Tozzi, A., Tantucci, M., Costa, C., Di, F. M., Autuori, A., Picconi, B., Siliquini, S., Luchetti, E., Borsini, F., and Calabresi, P. (2009) A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity. Exp. Neurol. 217:231-234. [PM:19416678].
  86. Blanco-Rivero, A., Leganes, F., Fernandez-Valiente, E., and Fernandez-Pinas, F. (2009) mrpA (all1838), a gene involved in alkali and Na(+) sensitivity, may also have a role in energy metabolism in the cyanobacterium Anabaena sp. strain PCC 7120. J. Plant Physiol 166:1488-1496. [PM:19410333].
  87. Guy, J., Qi, X., Koilkonda, R. D., Arguello, T., Chou, T. H., Ruggeri, M., Porciatti, V., Lewin, A. S., and Hauswirth, W. W. (2009) Efficiency and safety of AAV mediated gene delivery of the human ND4 complex I subunit in the mouse visual system. Invest Ophthalmol. Vis. Sci. 50:4205-4214. [PM:19387075].
  88. Hoefs, S. J., Dieteren, C. E., Rodenburg, R. J., Naess, K., Bruhn, H., Wibom, R., Wagena, E., Willems, P. H., Smeitink, J. A., Nijtmans, L. G., and Van den Heuvel, L. P. (2009) Baculovirus complementation restores a novel NDUFAF2 mutation causing complex I deficiency. Hum. Mutat. 30:E728-236. [PM:19384974].
  89. Rojas, J. C., John, J. M., Lee, J., and Gonzalez-Lima, F. (2009) Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy. Neurotox. Res. 15:260-273. [PM:19384599].
  90. Ding, H., Han, C., Guo, D., Chin, Y. W., Ding, Y., Kinghorn, A. D., and D'Ambrosio, S. M. (2009) Selective induction of apoptosis of human oral cancer cell lines by avocado extracts via a ROS-mediated mechanism. Nutr. Cancer 61:348-356. [PM:19373608].
  91. Hoffman, D. L. and Brookes, P. S. (2009) Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J. Biol. Chem. 284:16236-16245. [PM:19366681].
  92. Zickermann, V., Kerscher, S., Zwicker, K., Tocilescu, M. A., Radermacher, M., and Brandt, U. (2009) Architecture of complex I and its implications for electron transfer and proton pumping. Biochim. Biophys. Acta 1787:574-583. [PM:19366614].
  93. Maly, T., Zwicker, K., Cernescu, A., Brandt, U., and Prisner, T. F. (2009) New Pulsed EPR Methods and their Application to Characterize Mitochondrial Complex I. Biochim. Biophys. Acta 1787:584-592. [PM:19366602].
  94. Leshinsky-Silver, E., Lebre, A. S., Minai, L., Saada, A., Steffann, J., Cohen, S., Rotig, A., Munnich, A., Lev, D., and Lerman-Sagie, T. (2009) NDUFS4 mutations cause Leigh syndrome with predominant brainstem involvement. Mol. Genet. Metab 97:185-189. [PM:19364667].
  95. Drose, S., Hanley, P. J., and Brandt, U. (2009) Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III. Biochim. Biophys. Acta 1790:558-565. [PM:19364480].
  96. Sharma, L. K., Lu, J., and Bai, Y. (2009) Mitochondrial respiratory complex I: structure, function and implication in human diseases. Curr. Med. Chem. 16:1266-1277. [PM:19355884].
  97. Zimmermann, F. A., Mayr, J. A., Neureiter, D., Feichtinger, R., Alinger, B., Jones, N. D., Eder, W., Sperl, W., and Kofler, B. (2009) Lack of complex I is associated with oncocytic thyroid tumours. Br. J. Cancer 100:1434-1437. [PM:19352385].
  98. Drose, S., Galkin, A., and Brandt, U. (2009) Chapter 26 Measurement of superoxide formation by mitochondrial complex I of Yarrowia lipolytica. Methods Enzymol. 456:475-490. [PM:19348905].
  99. Cocheme, H. M. and Murphy, M. P. (2009) Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria. Methods Enzymol. 456:395-417. [PM:19348901].
  100. McKenzie, M., Lazarou, M., and Ryan, M. T. (2009) Chapter 18 Analysis of respiratory chain complex assembly with radiolabeled nuc. Methods Enzymol. 456:321-339. [PM:19348897].
  101. Fisher, N., Warman, A. J., Ward, S. A., and Biagini, G. A. (2009) Chapter 17 Type II NADH: quinone oxidoreductases of Plasmodium falciparum and Mycobacterium tuberculosis kinetic and high-throughput assays. Methods Enzymol. 456:303-320. [PM:19348896].
  102. Stehling, O., Sheftel, A. D., and Lill, R. (2009) Chapter 12 Controlled expression of iron-sulfur cluster assembly components for respiratory chain complexes in mammalian cells. Methods Enzymol. 456:209-231. [PM:19348891].
  103. de Wit, L. E. and Sluiter, W. (2009) Chapter 9 Reliable assay for measuring complex I activity in human blood lymphocytes and skin fibroblasts. Methods Enzymol. 456:169-181. [PM:19348888].
  104. Dieteren, C. E., Koopman, W. J., and Nijtmans, L. G. (2009) Chapter 7 Tracing human mitochondrial complex I assembly by use of GFP-tagged subunits. Methods Enzymol. 456:133-151. [PM:19348886].
  105. Belevich, N. P., Verkhovskaya, M. L., and Verkhovsky, M. I. (2009) Chapter 4 Electron transfer in respiratory complexes resolved by an ultra-fast freeze-quench approach. Methods Enzymol. 456:75-93. [PM:19348883].
  106. Marshall, D. and Rich, P. R. (2009) Chapter 3 Studies of complex I by Fourier transform infrared spectroscopy. Methods Enzymol. 456:53-74. [PM:19348882].
  107. Radermacher, M. (2009) Chapter 1 Visualizing functional flexibility by three-dimensional electron microscopy reconstructing complex I of the mitochondrial respiratory chain. Methods Enzymol. 456:3-27. [PM:19348880].
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