Publications (2003)

  1. Johnson, J. E., Jr., Choksi, K., and Widger, W. R. (2003) NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide. Mitochondrion. 3:97-110. [PM:16120348].
  2. Komaki, H., Akanuma, J., Iwata, H., Takahashi, T., Mashima, Y., Nonaka, I., and Goto, Y. (2003) A novel mtDNA C11777A mutation in Leigh syndrome. Mitochondrion. 2:293-304. [PM:16120329].
  3. Fernet, C., Claisse, M., and Clark-Walker, G. D. (2003) The mitochondrial genome of Debaryomyces (Schwanniomyces) occidentalis encodes subunits of NADH dehydrogenase complex I. Mitochondrion. 2:267-275. [PM:16120327].
  4. Tormo, J. R., Royo, I., Gallardo, T., Zafra-Polo, M. C., Hernandez, P., Cortes, D., and Pelaez, F. (2003) In vitro antitumor structure-activity relationships of threo/trans/threo mono-tetrahydrofuranic acetogenins: correlations with their inhibition of mitochondrial complex I. Oncol. Res. 14:147-154. [PM:14760863].
  5. Budde, S. M., Van den Heuvel, L. P., Smeets, R. J., Skladal, D., Mayr, J. A., Boelen, C., Petruzzella, V., Papa, S., and Smeitink, J. A. (2003) Clinical heterogeneity in patients with mutations in the NDUFS4 gene of mitochondrial complex I. J. Inherit. Metab Dis. 26:813-815. [PM:14765537].
  6. Pasdois, P., Deveaud, C., Voisin, P., Bouchaud, V., Rigoulet, M., and Beauvoit, B. (2003) Contribution of the phosphorylable complex I in the growth phase-dependent respiration of C6 glioma cells in vitro.J. Bioenerg. Biomembr. 35:439-450. [PM:14740892].
  7. Hano, N., Nakashima, Y., Shinzawa-Itoh, K., Terada, H., and Yoshikawa, S. (2003) Effect of pH on the steady state kinetics of bovine heart NADH: coenzyme Q oxidoreductase. J. Bioenerg. Biomembr. 35:419-425. [PM:14740890].
  8. Xu, G., Perez-Pinzon, M. A., and Sick, T. J. (2003) Mitochondrial complex I inhibition produces selective damage to hippocampal subfield CA1 in organotypic slice cultures. Neurotox. Res. 5:529-538. [PM:14715437].
  9. Niers, L., van den, H. L., Trijbels, F., Sengers, R., and Smeitink, J. (2003) Prerequisites and strategies for prenatal diagnosis of respiratory chain deficiency in chorionic villi. J. Inherit. Metab Dis. 26:647-658. [PM:14707513].
  10. Johnson, J. E., Choksi, K., and Widger, W. R. (2003) NADH-Ubiquinone oxidoreductase: substrate-dependent oxygen turnover to superoxide anion as a function of flavin mononucleotide. Mitochondrion 3:97 - 110.
  11. Chan, T. S. and O'Brien, P. J. (2003) Hepatocyte metabolism of coenzyme Q1 (ubiquinone-5) to its sulfate conjugate decreases its antioxidant activity. BioFactors 18:207-218. [PM:14695936].
  12. Nordman, T., Xia, L., Bjorkhem-Bergman, L., Damdimopoulos, A., Nalvarte, I., Arner, E. S., Spyrou, G., Eriksson, L. C., Bjornstedt, M., and Olsson, J. M. (2003) Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase. BioFactors 18:45-50. [PM:14695919].
  13. Bianchi, C., Fato, R., Genova, M. L., Parenti, C. G., and Lenaz, G. (2003) Structural and functional organization of Complex I in the mitochondrial respiratory chain. BioFactors 18:3-9. [PM:14695915].
  14. Lebon, S., Chol, M., Benit, P., Mugnier, C., Chretien, D., Giurgea, I., Kern, I., Girardin, E., Hertz-Pannier, L., De Lonlay, P., Rotig, A., Rustin, P., and Munnich, A. (2003) Recurrent de novo mitochondrial DNA mutations in respiratory chain deficiency. J. Med. Genet. 40:896-899. [PM:14684687].
  15. Grivennikova, V. G., Roth, R., Zakharova, N. V., Hagerhall, C., and Vinogradov, A. D. (2003) The mitochondrial and prokaryotic proton-translocating NADH:ubiquinone oxidoreductases: similarities and dissimilarities of the quinone-junction sites. Biochim. Biophys. Acta 1607:79-90. [PM:14670598].
  16. Feldkamp, T., Kribben, A., Roeser, N. F., Senter, R. A., Kemner, S., Venkatachalam, M. A., Nissim, I., and Weinberg, J. M. (2003) PRESERVATION OF COMPLEX I FUNCTION DURING HYPOXIA/REOXYGENATION-INDUCED MITOCHONDRIAL INJURY IN PROXIMAL TUBULES. Am. J. Physiol Renal Physiol [PM:14665431].
  17. Grad, L. I. and Lemire, B. D. (2003) Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress, and vitamin-responsive lactic acidosis. Hum. Mol. Genet.13:303-314 [PM:14662656].
  18. Jasso-Chavez, R. and Moreno-Sanchez, R. (2003) Cytosol-mitochondria transfer of reducing equivalents by a lactate shuttle in heterotrophic Euglena. Eur. J. Biochem. 270:4942-4951. [PM:14653820].
  19. Miwa, S. and Brand, M. D. (2003) Mitochondrial matrix reactive oxygen species production is very sensitive to mild uncoupling.Biochem. Soc. Trans. 31:1300-1301. [PM:14641047].
  20. Sherer, T. B., Betarbet, R., Testa, C. M., Seo, B. B., Richardson, J. R., Kim, J. H., Miller, G. W., Yagi, T., Matsuno-Yagi, A., and Greenamyre, J. T. (2003) Mechanism of toxicity in rotenone models of Parkinson's disease. J. Neurosci. 23:10756-10764. [PM:14645467].
  21. Monteiro, P., Oliveria, P. J., Goncalves, L. M., and Providencia, L. A. (2003) Trimetazidine-mediated cardioprotection during ischemia is mediated by mitochondrial respiratory chain's complex I activity.J. Am. Coll. Cardiol. 41:373- [ PM:14637555].
  22. Atorino, L., Silvestri, L., Koppen, M., Cassina, L., Ballabio, A., Marconi, R., Langer, T., and Casari, G. (2003) Loss of m-AAA protease in mitochondria causes complex I deficiency and increased sensitivity to oxidative stress in hereditary spastic paraplegia. J. Cell Biol. 163:777-787. [PM:14623864].
  23. Stroh, A., Anderka, O., Pfeiffer, K., Yagi, T., Finel, M., Ludwig, B., and Schagger, H. (2003) Assembly of respiratory complexes I, III, and IV into NADH oxidase supercomplex stabilizes complex I in Paracoccus denitrificans. J. Biol. Chem.279:5000-5007 [PM:14610094].
  24. Shamoto-Nagai, M., Maruyama, W., Kato, Y., Isobe, K., Tanaka, M., Naoi, M., and Osawa, T. (2003) An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells. J. Neurosci. Res. 74:589-597. [PM:14598303].
  25. Ugalde, C., Triepels, R. H., Coenen, M. J., Van den Heuvel, L. P., Smeets, R., Uusimaa, J., Briones, P., Campistol, J., Majamaa, K., Smeitink, J. A., and Nijtmans, L. G. (2003) Impaired complex I assembly in a Leigh syndrome patient with a novel missense mutation in the ND6 gene. Ann. Neurol. 54:665-669. [PM:14595656].
  26. Dawson, T. M. and Dawson, V. L. (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302:819-822. [PM:14593166].
  27. Tormo, J. R., Gallardo, T., Peris, E., Bermejo, A., Cabedo, N., Estornell, E., Zafra-Polo, M. C., and Cortes, D. (2003) Inhibitory effects on mitochondrial complex I of semisynthetic mono-Tetrahydrofuran acetogenin derivatives. Bioorg. Med. Chem. Lett. 13:4101-4105. [PM:14592516].
  28. Tada-Oikawa, S., Hiraku, Y., Kawanishi, M., and Kawanishi, S. (2003) Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis. Life Sci. 73:3277-3288. [PM:14561532].
  29. Orth, M., Tabrizi, S. J., Schapira, A. H., and Cooper, J. M. (2003) Alpha-synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone. Neurosci. Lett. 351:29-32.[PM:14550906].
  30. Kita, K., Nihei, C., and Tomitsuka, E. (2003) Parasite mitochondria as drug target: diversity and dynamic changes during the life cycle. Curr. Med. Chem. 10:2535-2548.[PM:14529469].
  31. Kotake, Y. and Ohta, S. (2003) MPP(+) Analogs Acting on Mitochondria and Inducing Neuro-Degeneration. Curr. Med. Chem. 10:2507-2516.[PM:14529466].
  32. Lannuzel, A., Michel, P. P., Hoglinger, G. U., Champy, P., Jousset, A., Medja, F., Lombes, A., Darios, F., Gleye, C., Laurens, A., Hocquemiller, R., Hirsch, E. C., and Ruberg, M. (2003) The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism. Neuroscience 121:287-296.[PM:14521988].
  33. Solano, A., Roig, M., Vives-Bauza, C., Hernandez-Pena, J., Garcia-Arumi, E., Playan, A., Lopez-Perez, M. J., Andreu, A. L., and Montoya, J. (2003) Bilateral striatal necrosis associated with a novel mutation in the mitochondrial ND6 gene. Ann. Neurol. 54:527-530.[PM:14520668].
  34. Kirby, D. M., Boneh, A., Chow, C. W., Ohtake, A., Ryan, M. T., Thyagarajan, D., and Thorburn, D. R. (2003) Low mutant load of mitochondrial DNA G13513A mutation can cause Leigh's disease. Ann. Neurol. 54:473-478. [PM:14520659].
  35. Leng, A., Feldon, J., and Ferger, B. (2003) Rotenone increases glutamate-induced dopamine release but does not affect hydroxyl-free radical formation in rat striatum. SYNAPSE 50:240-250. [PM:14515342].
  36. Maklashina, E., Kotlyar, A. B., and Cecchini, G. (2003) Active/de-active transition of respiratory complex I in bacteria, fungi, and animals. Biochim. Biophys. Acta 1606:95-103. [PM:14507430].
  37. Hano, N., Nakashima, Y., Shinzawa-Itoh, K., and Yoshikawa, S. (2003) Effect of the side chain structure of coenzyme Q on the steady state kinetics of bovine heart NADH: coenzyme Q oxidoreductase. J. Bioenerg. Biomembr. 35:257-265. [PM:13678276].
  38. Flemming, D., Schlitt, A., Spehr, V., Bischof, T., and Friedrich, T. (2003) Iron-sulfur cluster N2 of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I) is located on subunit NuoB. J. Biol. Chem. 278:47602-47609. [PM:12975362].
  39. Eubel, H., Jansch, L., and Braun, H. P. (2003) New Insights into the Respiratory Chain of Plant Mitochondria. Supercomplexes and a Unique Composition of Complex II. Plant Physiol 133:274-286. [PM:12970493].
  40. Kenchappa, R. S. and Ravindranath, V. (2003) gamma-Glutamyl cysteine synthetase is up-regulated during recovery of brain mitochondrial complex I following neurotoxic insult in mice. Neurosci. Lett. 350:51-55. [PM:12962915].
  41. Scacco, S., Petruzzella, V., Budde, S., Vergari, R., Tamborra, R., Panelli, D., Van den Heuvel, L. P., Smeitink, J. A., and Papa, S. (2003) Pathological mutations of the human NDUFS4 gene of the 18 kDa (AQDQ) subunit of complex I affect the expression of the protein and the assembly and function of the complex. J. Biol. Chem. 278:44161-44167. [PM:12944388].
  42. Aoyama, M., Shidoji, Y., Saimei, M., Tsunawake, N., and Ichinose, M. (2003) Phenotypic linkage between single-nucleotide polymorphisms of beta(3)-adrenergic receptor gene and NADH dehydrogenase subunit-2 gene, with special reference to eating behavior. Biochem. Biophys. Res. Commun. 309:261-265. [PM:12943691].
  43. Antonicka, H., Ogilvie, I., Taivassalo, T., Anitori, R. P., Haller, R. G., Vissing, J., Kennaway, N. G., and Shoubridge, E. A. (2003) Identification and characterization of a common set of complex I assembly intermediates in mitochondria from patients with complex I deficiency. J. Biol. Chem. 278:43081-43088. [PM:12941961].
  44. Wedel, T., Tafazzoli, K., Sollner, S., Krammer, H. J., Aring, C., and Holschneider, A. M. (2003) Mitochondrial myopathy (complex I deficiency) associated with chronic intestinal pseudo-obstruction. Eur. J. Pediatr. Surg. 13:201-205. [PM:12939706].
  45. Garofano, A., Zwicker, K., Kerscher, S., Okun, P., and Brandt, U. (2003) Two aspartic acid residues in the PSST-homologous NUKM subunit of complex I from Yarrowia lipolytica are essential for catalytic activity. J. Biol. Chem. 278:42435-42440. [PM:12930834].
  46. Holt, P. J., Morgan, D. J., and Sazanov, L. A. (2003) The location of NuoL and NuoM subunits in the membrane domain of the Escherichia coli complex I: Implications for the mechanism of proton pumping. J. Biol. Chem. 278:43114-43120. [PM:12923180].
  47. Nakamaru-Ogiso, E., Seo, B. B., Yagi, T., and Matsuno-Yagi, A. (2003) Amiloride inhibition of the proton-translocating NADH-quinone oxidoreductase of mammals and bacteria. FEBS Lett. 549:43-46. [PM:12914922].
  48. Grivennikova, V. G., Ushakova, A. V., Cecchini, G., and Vinogradov, A. D. (2003) Unidirectional effect of lauryl sulfate on the reversible NADH:ubiquinone oxidoreductase (Complex I). FEBS Lett. 549:39-42. [PM:12914921].
  49. Mathiesen, C. and Hagerhall, C. (2003) The 'antiporter module' of respiratory chain complex I includes the MrpC/NuoK subunit -- a revision of the modular evolution scheme. FEBS Lett. 549:7-13. [PM:12914915].
  50. Hoglinger, G. U., Carrard, G., Michel, P. P., Medja, F., Lombes, A., Ruberg, M., Friguet, B., and Hirsch, E. C. (2003) Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease. J. Neurochem. 86:1297-1307. [PM:12911637].
  51. Wolf, N. I., Seitz, A., Harting, I., Smeitink, J. A., Trijbels, F., Van den Heuvel, L. P., Schlemmer, H., Ebinger, F., Evert, W., and Rating, D. (2003) New pattern of brain MRI lesions in isolated complex I deficiency. Neuropediatrics 34:156-159. [PM:12910441].
  52. Ino, T., Nishioka, T., and Miyoshi, H. (2003) Characterization of inhibitor binding sites of mitochondrial complex I using fluorescent inhibitor. Biochim. Biophys. Acta 1605:15-20. [PM:12907297].
  53. Royo, I., DePedro, N., Estornell, E., Cortes, D., Pelaez, F., and Tormo, J. R. (2003) In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I. Oncol. Res. 13:521-528. [PM:12899242].
  54. Gu, G., Deutch, A. Y., Franklin, J., Levy, S., Wallace, D. C., and Zhang, J. (2003) Profiling genes related to mitochondrial function in mice treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem. Biophys. Res. Commun. 308:197-205. [PM:12890501].
  55. Qi, X., Lewin, A. S., Hauswirth, W. W., and Guy, J. (2003) Suppression of complex I gene expression induces optic neuropathy. Am. J. Ophthalmol.136:399- [PM:12888092].
  56. Ceaser, E. K., Ramachandran, A., Levonen, A. L., and Darley-Usmar, V. M. (2003) Oxidized Low Density Lipoprotein and 15-Deoxy-d 12,14-prostaglandin J2 increase mitochondrial complex I activity in endothelial cells. Am. J. Physiol Heart Circ. Physiol 285:H2298-H2308. [PM:12881207].
  57. Howell, N. (2003) LHON and other optic nerve atrophies: the mitochondrial connection. Dev. Ophthalmol. 37:94-108. [PM:12876832].
  58. Ohkura, K., Lee, J. D., Shimizu, H., Nakano, A., Uzui, H., Horikoshi, M., Fujibayashi, Y., Yonekura, Y., and Ueda, T. (2003) Mitochondrials complex I activity is reduced in latent adriamycin-induced cardiomyopathy of rat. Mol. Cell Biochem. 248:203-208. [PM:12870675].
  59. Murray, J., Taylor, S. W., Zhang, B., Ghosh, S. S., and Capaldi, R. A. (2003) Oxidative damage to mitochondrial complex I due to peroxynitrite; Identification of reactive tyrosines by mass spectrometry. J. Biol. Chem. 278:37223-37230. [PM:12857734].
  60. Simonnet, H., Demont, J., Pfeiffer, K., Guenaneche, L., Bouvier, R., Brandt, U., Schagger, H., and Godinot, C. (2003) Mitochondrial complex I is deficient in renal oncocytomas. Carcinogenesis 24:1461-1466. [PM:12844484].
  61. Heazlewood, J. L., Howell, K. A., and Millar, A. H. (2003) Mitochondrial complex I from Arabidopsis and rice: orthologs of mammalian and fungal components coupled with plant-specific subunits. Biochim. Biophys. Acta 1604:159-169. [PM:12837548].
  62. Hirst, J., Carroll, J., Fearnley, I. M., Shannon, R. J., and Walker, J. E. (2003) The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim. Biophys. Acta 1604:135-150. [PM:12837546].
  63. Genova, M. L., Bianchi, C., and Lenaz, G. (2003) Structural organization of the mitochondrial respiratory chain. Ital. J. Biochem. 52:58-61. [PM:12833641].
  64. Grazina, M., Silva, F., Januario, C., Oliveira, M., Cunha, L., and Oliveira, C. (2003) Parkinson's Disease and Mitochondrial DNA NADH Dehydrogenase Subunit 1 Nucleotides 3337-3340: Study in a Population from the Central Region of Portugal (Coimbra). Eur. Neurol. 50:60-61. [PM:12824717].
  65. Yabunaka, H., Abe, M., Kenmochi, A., Hamada, T., Nishioka, T., and Miyoshi, H. (2003) Synthesis and inhibitory activity of ubiquinone-acetogenin hybrid inhibitor with bovine mitochondrial complex I. Bioorg. Med. Chem. Lett. 13:2385-2388. [PM:12824040].
  66. Jekabsone, A., Ivanoviene, L., Brown, G. C., and Borutaite, V. (2003) Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release. J. Mol. Cell Cardiol. 35:803-809. [PM:12818571].
  67. Washizuka, S., Kakiuchi, C., Mori, K., Kunugi, H., Tajima, O., Akiyama, T., Nanko, S., and Kato, T. (2003) Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am. J. Med. Genet. 120B:72-78. [PM:12815743].
  68. Crimi, M., Galbiati, S., Moroni, I., Bordoni, A., Perini, M. P., Lamantea, E., Sciacco, M., Zeviani, M., Biunno, I., Moggio, M., Scarlato, G., and Comi, G. P. (2003) A missense mutation in the mitochondrial ND5 gene associated with a Leigh-MELAS overlap syndrome. Neurology 60:1857-1861. [PM:12796552].
  69. Brandt, U., Kerscher, S., Drose, S., Zwicker, K., and Zickermann, V. (2003) Proton pumping by NADH:ubiquinone oxidoreductase. A redox driven conformational change mechanism? FEBS Lett. 545:9-17. [PM:12788486].
  70. Zu, Y., Shannon, R. J., and Hirst, J. (2003) Reversible, Electrochemical Interconversion of NADH and NAD+ by the Catalytic (Ilambda) Subcomplex of Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I). J. Am. Chem. Soc. 125:6020-6021. [PM:12785808].
  71. Schulenberg, B., Aggeler, R., Beechem, J. M., Capaldi, R. A., and Patton, W. F. (2003) Analysis of steady-state protein phosphorylation in mitochondria using a novel fluorescent phosphosensor dye. J. Biol. Chem. 278:27251-27255. [PM:12759343].
  72. Marques, I., Duarte, M., and Videira, A. (2003) The 9.8 kDa Subunit of Complex I, Related to Bacterial Na+-translocating NADH Dehydrogenases, is Required for Enzyme Assembly and Function in Neurospora crassa. J. Mol. Biol. 329:283-290. [PM:12758076].
  73. Simon, D. K., Friedman, J., Breakefield, X. O., Jankovic, J., Brin, M. F., Provias, J., Bressman, S. B., Charness, M. E., Tarsy, D., Johns, D. R., and Tarnopolsky, M. A. (2003) A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia. Neurogenetics. 4:199-205. [PM:12756609].
  74. Zickermann, V., Bostina, M., Hunte, C., Ruiz, T., Radermacher, M., and Brandt, U. (2003) Functional implications from an unexpected position of the 49 kDa subunit of complex I. J. Biol. Chem. 278:29072-29078. [PM:12754256].
  75. Sousa, S. C., Maciel, E. N., Vercesi, A. E., and Castilho, R. F. (2003) Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone.FEBS Lett. 543:179-183. [PM:12753929].
  76. Steuber, J. (2003) The C-terminally truncated NuoL subunit (ND5 homologue) of the Na+ -dependent complex I from Escherichia coli transports Na+.J. Biol. Chem. 278:26817-26822. [PM:12740360].
  77. Xu, Z. F., Wei, X. Y., Xie, H. H., and Yang, R. Z. (2003) Inhibitory Activities of Three Annonaceous Acetogenins on NADH Oxidase of Chicken Liver Mitochondria. Biol. Pharm. Bull. 26:729-732. [PM:12736522].
  78. Gong, X., Xie, T., Yu, L., Hesterberg, M., Scheide, D., Friedrich, T., and Yu, C. A. (2003) The ubiquinone-binding site in NADH: Ubiquinone oxidoreductase from Escherichia coli. J. Biol. Chem. 278:25731-25737. [PM:12730198].
  79. Parsons, R. B., Smith, S. W., Waring, R. H., Williams, A. C., and Ramsden, D. B. (2003) High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease.Neurosci. Lett. 342:13-16. [PM:12727306].
  80. Taylor, S. W., Fahy, E., Murray, J., Capaldi, R. A., and Ghosh, S. S. (2003) Oxidative Post-translational Modification of T ryptophan Residues in Cardiac Mitochondrial Proteins. J. Biol. Chem. 278:19587-19590. [PM:12679331].
  81. Briet, F., Twomey, C., and Jeejeebhoy, K.N. (2003) Relationship between metabolism and peripheral blood mononuclear cell mitochondrial complex I activity before and after a short-term refeeding in weight-losing cancer patients . Clin. Nutr. 22:247-253. [PM:12765663].
  82. Benit. P., Beugnot, R., Chretien, D., Giurgea, I., De Lonlay-Debeney, P., Issartel, J.P., Corral-Debrinski, M., Kerscher, S., Rustin, P., Rotig, A., and Munnich, A. (2003) Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy. Hum. Mutat. 21:582-586. [PM:12754703].
  83. Amarneh, B. and Vik, S. B. (2003) Mutagenesis of subunit N of the Escherichia coli complex I. Identification of the initiation codon and the sensitivity of mutants to decylubiquinone. Biochemistry 42:4800-4808. [PM:12718520].
  84. Briet, F., Twomey, C., and Jeejeebhoy, K. N. (2003) Effect of malnutrition and short-term refeeding on peripheral blood mononuclear cell mitochondrial complex I activity in humans. Am. J. Clin. Nutr. 77:1304-1311. [PM:12716686].
  85. Kayser, E. B., Hoppel, C. L., Morgan, P. G., and Sedensky, M. M. (2003) A mutation in mitochondrial complex I increases ethanol sensitivity in Caenorhabditis elegans. Alcohol Clin. Exp. Res. 27:584-592. [PM:12711920].
  86. Genova, M. L., Pich, M. M., Biondi, A., Bernacchia, A., Falasca, A., Bovina, C., Formiggini, G., Castelli, G. P., and Lenaz, G. (2003) Mitochondrial production of oxygen radical species and the role of coenzyme Q as an antioxidant. Exp. Biol. Med. (Maywood. ) 228:506-513. [PM:12709577].
  87. Deschauer, M., Bamberg, C., Claus, D., Zierz, S., Turnbull, D. M., and Taylor, R. W. (2003) Late-onset encephalopathy a ssociated with a C11777A mutation of mitochondrial DNA. Neurology 60:1357-1359. [PM:12707444].
  88. Kao, M.-C., Di Bernardo, S., Matsuno-Yagi, A., and Yagi, T. (2003) Characterization and topology of the membrane domain Nqo10 subunit of the proton-translocating NADH-quinone oxidoreductase of Paracoccus denitrificans. Biochemistry 42:4534-4543. [PM:12693950].
  89. Van Der Westhuizen, F. H., Van den Heuvel, L. P., Smeets, R., Veltman, J. A., Pfundt, R., Van Kessel, A. G., Ursing, B. M., and Smeitink, J. A. (2003) Human mitochondrial complex I deficiency: investigating transcriptional responses by microarray. Neuropediatrics 34:14-22. [PM:12690563].
  90. Pawlowska, J., Tarasiuk, J., Wolf, C. R., Paine, M. J., and Borowski, E. (2003) Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol. Res. 13:245-252. [PM:12688675].
  91. Fernandes, A. S., Pereira, M. M., and Teixeira, M. (2002) Purification and characterization of the complex I from the respiratory chain of Rhodothermus marinus. J. Bioenerg. Biomembr. 34:413-421. [PM:12678433].
  92. Beal, M. F. (2003) Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann. Neurol. 53:S39-S48. [PM:12666097].
  93. Powell, C. S. and Jackson, R. M. (2003) Mitochondrial Complex I, aconitase and succinate dehydrogenase during hypoxia-reoxygenation: Modulation of enzyme activities by MnSOD. Am. J. Physiol Lung Cell Mol. Physiol 285:L 189-198. [PM:12665464].
  94. Su, Z. H., Imura, Y., Zhou, H. Z., Okamoto, M., and Osawa, S. (2003) Mode of morphological differentiation in the Latitarsi-ground beetles (Coleoptera, Carabidae) of the world inferred from a phylogenetic tree of mitochondrial ND5 gene sequences. Genes Genet. Syst. 78:53-70. [PM:12655138].
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  133. Ricci, J. E., Gottlieb, R. A., and Green, D. R. (2003) Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J. Cell Biol. 160:65-75. [PM:12515825].
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