Publications (1999)

  1. Tormo, J. R., Gallardo, T., Aragon, R., Cortes, D., and Estornell, E. (1999) Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I . Chem. Biol. Interact. 122:171-183.
  2. Frenkin, M. V. and Kotlyar, A. B. (1999) Arylazido-beta-alanine ADP-ribose, a novel irreversible competitive inhibitor of mitochondrial NADH-ubiquinone reductase. Biochim. Biophys. Acta 1413:139-146.
  3. Zhou, W., Bertsova, Y. V., Feng, B., Tsatsos, P., Verkhovskaya, M. L., Gennis, R. B., Bogachev, A. V., and Barquera, B. (1999) Sequencing and preliminary characterization of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio harveyi. Biochemistry 38:16246-16252.
  4. Pulkes, T., Eunson, L., Patterson, V., Siddiqui, A., Wood, N. W., Nelson, I. P., Morgan-Hughes, J. A., and Hanna, M. G. (1999) The mitochondrial DNA G13513A transition in ND5 is associated with a LHON/MELAS overlap syndrome and may be a frequent cause of MELAS. Ann. Neurol. 46:916-919.
  5. Wackwitz, B., Bongaerts, J., Goodman, S. D., and Unden, G. (1999) Growth phase-dependent regulation of nuoA-N expression in Escherichia coli K-12 by the Fis protein: upstream binding sites and bioenergetic significance. Mol. Gen. Genet. 262:876- 883.
  6. Spehr, V.,  Schlitt, A., Scheide, D., Guenebaut, V., and  Friedrich, T. (1999) Overexpression of the Escherichia coli nuo-operon and isolation of the overproduced NADH:Ubiquinone oxidoreductase (Complex I). Biochemistry 38:16261-16267.
  7. Bungert, S., Krafft, B., Schlesinger, R., and  Friedrich, T. (1999) One-step purification of the NADH dehydrogenase fragment of the Escherichia coli complex I by means of strep-tag affinity chromatography. FEBS Lett. 460:207-211.
  8. Schulte, U., Haupt, V., Abelmann, A.,  Fecke, W.,  Brors, B., Rasmussen, T., Friedrich, T., and Weiss, H. (1999)  A reductase/isomerase subunit of mitochondrial NADH:ubiquinone oxidoreductase (complex I) carries an NADPH and is involved in the biogenesis of the complex.  J.Mol.Biol. 292:569-580.
  9. Almeida, T., Durante, M., Melo, A.M.P., and Videira, A. (1999) The 24-kDa iron-sulphur subunit of complex I is required for enzyme activity. Eur.J.Biochem. 265: 86-92.
  10. Kösel, S., Hofhaus, G., Maassen, A., Vieregge, P., and Graeber, M.B. (1999) Role of mitochondria in Parkinson disease. Biol.Chem.Hoppe Seyler 380: 865-870.
  11. Frederiks, W.M., Bosch, K.S., Vreeling-Sindelárová, H. (1999) Effects of ischemia and reperfusion on NADH coenzyme Q reductase activity in rat liver. Histochem.J. 31: 609-615.
  12. Balijepalli, S., Annepu, J., Boyd, M.R., and Ravindranath, V. (1999) Effect of thiol modification on brain mitochondrial complex I activity. Neurosci.Lett.272: 203-206.
  13. Iwata, J., Miyoshi, H., and Iwamura, H. (1999) Origin of selective inhibition of mitochondrial complex I by pyridinium-type inhibitor MP-24. Biochim. Biophys. Acta 1413: 63-69.
  14. Konishi, K., and Tanaka, T. (1999) Inhibitory effects of tannins on the NADH dehydrogenase activity of bovine heart mitochondrial complex I. Biol.Pharm.Bull. 22: 240-243.
  15. Yano,T., Magnitsky, S., Sled', V.D., Ohnishi, T., and Yagi, T. (1999) Characterization of the putative 2 x [4Fe-4S]-binding NQO9 subunit of the proton-translocating NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Expression, reconstitution, and EPR characterization. J.Biol.Chem.274:28598-28605.
  16. Yano,T., and Yagi, T. (1999) H+-translocating NADH-quinone oxidoreductase (NDH-1) of Paracoccus denitrificans. Studies on topology and stoichiometry of the peripheral subunits. J.Biol.Chem. 274:28606-28611.
  17. Tormo, J.R., Gonzalez, M.C., Cortes, D., and Estornell, E. (1999) Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins. Arch.Biochem.Biophys. 369:119-126.
  18. Krebs, W., Steuber, J., Gemperli, A.C., and Dimroth, P. (1999) Na+ translacation by the NADH:ubiquinone oxidoreductase (complex I) from Klebsiella pneumoniae . Mol.Microbiol. 33:590-598.
  19. Melo, A.M.P., Duarte, M., and Videira, A. (1999) Primary structure and characterization of a 64 kDa NADH dehydrogenase from the inner membrane of Neurospora crassa mitochondria. Biochim.Biophys.Acta1412:282-287.
  20. Ferreirinha, F., Durante, M., Melo, A.M.P., and Videira, A. (1999) Effects of disrupting the 21kDa subunit of complex I from Neurospora crassa.Biochem.J.342:551-554.
  21. Grigorieff,N. (1999) Structure of the respiratoty NADH:ubiquinone ocidoreductase (complex I). Curr.Opin.Struct.Biol. 9:476-483.
  22. Brandt, U. (1999) Proton translocation in the respiratory chain involving ubiquinone - A hypothetical semiquinone switch mechanism for complex I. BioFactors 9 2-4:95-101.
  23. Rich, P., and Fisher, N. (1999) Genetic features of quinone-binding sites. Biochem.Soc.Trans. 27: 561-565.
  24. Ohnishi, T., Magnitsky, S., Toulokhonova, L., Yano, T., Yagi, T., Burbaev, D.S., and Vinogradov, A.D. (1999) EPR studies of the possible binding sites of the cluster N2, semiquinones, and specific inhibitors of the NADH:quinone oxidoreductase (complex I). Biochem.Soc.Trans. 27:586-590.
  25. Okun, J. G., Zickermann, V., and Brandt, U. (1999) Properties of the common inhibitor binding domain in mitochondrial NADH-dehydrogenase (complex I). Biochem.Soc.Trans. 27:596-601.
  26. Esposti, M.D., and Ghelli, A. (1999) Ubiquinone and inhibitor sites in complex I: one, two or three?  Biochem.Soc.Trans. 27: 606-609.
  27. Aksenov, M.Y., Tucker, H.M., Nair, P., Aksenova, M.V., Butterfield, D.A., Estus, S., and Markesbery, W.R. (1999) The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease. Neurochem.Res. 24:767-774.
  28. Barrientos, A., and Moraes, C.T. (1999) Titrating the effects of mitochondrial complex I impairment in the cell physiology. J.Biol.Chem. 274:16188-16197.
  29. Boison, G., Bothe, H., Hansel, A., and Lindblad, P. (1999) Evidence against a common use of the diaphorase subunits by the bidirectional hydrogenase and by the respiratory complex I in cyanobacteria. FEMS Microbiol.Lett.174 :159-165.
  30. Braidot, E., Petrussa, E., Vianello, A., and Macrì, F. (1999) Hydrogen peroxide generation by higher plant mitochondria oxidizing complex I or complex II substrates. FEBS Lett. 451:347-350.
  31. Gellerich, F.N., Trumbeckaite, S., Hertel, K., Zierz, S., Muller-Werdan, U., Werdan, K., Redl, H., and Schlag, G. (1999) Impaired energy metabolism in hearts of septic baboons: Diminished activities of Complex I and Complex II of the mitochondrial respiratory chain. Shock 11:336-341.
  32. Torres-Mendoza, C.E., Albert, A., and Arriaga, M.J.D. (1999) Molecular study of the rat liver NADH:cytochrome c oxidoreductase complex during development and ageing. Mol.Cell.Biochem. 195:133-142.
  33. Chen, M., Andersen, L.P., Zhai, L., and Kharazmi, A. (1999) Characterization of the respiratory chain of Helicobacter pylori. FEMS Immunol.Med.Microbiol. 24:169-174.
  34. Combettes, B., and Grienenberger, J.M. (1999) Analysis of wheat mitochondrial complex I purified by a one-step immunoaffinity chromatography. Biochimie81:645-653.
  35. Galkin, A.S., Grivennikova, V.G., and Vinogradov, A.D. (1999) -->H+/2e stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. FEBS Lett. 451:157-161.
  36. Gavrikova, E.V., and Vinogradov, A.D. (1999) Active/de-active state transition of the mitochondrial complex I as revealed by specific sulfhydryl group labeling. FEBS Lett. 455:36-40.
  37. Gutierres, S., Combettes, B., De Paepe, R., Mirande, M., Lelandais, C., Vedel, F., and Chétrit, P. (1999) In the Nicotiana sylvestris CMSII mutant, a recombination-mediated change 5' to the first exon of the mitochondrial nad1 gene is associated with lack of the NADH:ubiquinone oxidoreductase (complex I) NAD1 s ubunit. Eur.J.Biochem. 261:361-370.
  38. Hirai, K.I., Shimada, H., Pan, J.H., Katoh, S., and Simamura, E. (1999) Mitochondrial NADH-quinone oxidoreductase (NQOm) produces reactive oxygen species in the chemical injury of rat liver mitochondria. Acta Histochem.Cytochem.32:239-242.
  39. Jewess, P.J., and Devonshire, A.L. (1999) Kinetic microplate-based assays for inhibitors of mitochondrial NADH:Ubiquinone oxidoreductase (complex I) and Succinate:Cytochrome c oxidoreductase. Anal.Biochem.272:56-63.
  40. Otten, M.F., Reijnders, W.N., Bedaux, J.J., Westerhoff, H.V., Krab, K., and Van Spanning, R.J. (1999) The reduction state of the Q-pool regulates the electron flux through the branched respiratory network of Paracoccus denitrificans. Eur.J.Biochem. 261:767-774.
  41. Ragone, G., Caizzi, R., Moschetti, R., Barsanti, P., De Pinto, V., and Caggese, C. (1999) The Drosophila melanogaster gene for the NADH:ubiquinone oxidoreductase acyl carrier protein: developmental expression analysis and evidence for alternatively spliced forms. Mol.Gen.Genet.261:690-697.
  42. Smeitink, J., and Van den Heuvel, L. (1999) Human mitochondrial complex I in health and disease. Am.J.Hum.Genet. 64:1505-1510.
  43. Taivassalo, T., Fu, K., Johns, T., Arnold, D., Karpati, G., and Shoubridge, E.A. (1999) Gene shifting: a novel therapy for mitochondrial myopathy. Hum.Mol.Genet.8:1047-1052.
  44. Tensing, K., Pata, I., Wittig, I., Wehnert, M., and Metspalu, A. (1999) Genomic organization of the human complex I 13-kDa subunit gene NDUFA5. Cytogenet.Cell Genet. 84:125-127.
  45. Triepels, R.H., Van den Heuvel, L.P., Loeffen, J.L., Buskens, C.A., Smeets, R.J., Gozalbo, M.E., Budde, S.M., Mariman, E.C., Wijburg, F.A., Barth, P.G., Trijbels, J.M., and Smeitink, J.A. (1999) Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I. Ann.Neurol. 45:787-790.
  46. Yamato, K.T., and Newton, K.J. (1999) Heteroplasmy and homoplasmy for maize mitochondrial mutants: A rare homoplasmic nad4 deletion mutant plant. J.Hered. 90:369-373.
  47. Cook-Johnson, R.J., Zhang, Q., Wiskich, J.T., and Soole, K.L. (1999) The nuclear origin of the non-phosphorylating NADH dehydrogenases of plant mitochondria. FEBS Lett. 454:37-41.
  48. Weider, L.J., Hobaek, A., Colbourne, J.K., Crease, T.J., Dufresne, F., Hebert, P.D.N. (1999) Holarctic phylogeography of an aswxual species complex I. Mitochondrial DNA variation in arctic Daphnia. Evolution53:777-792.
  49. Soldner, F., Weller, M., Haid, S., Beinroth, S., Miller, S.W., Wullner, U., Davis, R.E., Dichgans, J., Klockgether, T., and Schulz, J.B. (1999) MPP+ inhibits proliferation of PC12 cells by a p21 WAF1/Cip1-dependent pathway and induces cell death lacking p21 WAF1/Cip1. Exp.Cell Res.250:75-85.
  50. Kerscher, S.J., Okun, J.G., and Brandt, U. (1999) A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica. J. Cell Sci. 112:2347-2354.
  51. Triepels, R., Smeitink, J., Loeffen, J., Smeets, R., Buskens, C., Trijbels, F., van den Heuvel, L. (1999) The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the mitochondrial complex I in human pathology. J. Inherit. Metab. Dis. 22:163-173.
  52. Feillet, F., Mousson, B., Grignon, Y., Leonard, J.V., and Vidailhet, M. (1999) Necrotizing encephalopathy and macrocephaly with mitochondrial complex I deficiency. Pediatr. Neurol. 20:305-308.
  53. Kirby, D.M., Crawford, M., Cleary, M.A., Dahl, H.H.M., Dennett, X., and Thorburn, D.R. (1999) Respiratory chain complex I deficiency - An underdiagnosed energy generation disorder. Neurology 52:1255-1264.
  54. Baker, M.E., Grundy, W.N., and Elkan, C.P. (1999) A common ancester for a subunit in the mitochondrial proton-translocatiog NADH:ubiquinone oxidoreductase (complex I) and short-chain dehydrogenases/reductases.Cell. Mol. Life Sci. 55:450-455.
  55. Balijepalli, S., Boyd, M.R., and Ravindranath, V. (1999) Inhibition of mitochondrial complex I by haloperidol: the role of thiol oxidation. Neuropharmacology38:567-577.
  56. Karpova, O.V., and Newton, K.J. (1999) A partially assembled complex I in NAD4-deficient mitochondria of maize. Plant J. 17511-521.
  57. Seo, B.B., Matsuno-Yagi, A., and Yagi, T. (1999) Modulation of oxidative phosphorylation of human kidney 293 cells by transfection with the internal rotenone-insensitive NADH-quinone oxidoreductase (NDI1) gene of Saccharomyces cerevisiae. Biochim. Biophys. Acta 1412:56-65.
  58. Sousa, R., Barquera, B., Duarte, M., Finel, M., and Videira, A. (1999) Characterisation of the last Fe-S cluster-binding subunit of Neurospora crassa complex I. Biochim. Biophys. Acta 1411:142-146.
  59. Zakharova, N.V., Zharova, T.V., and Vinogradov, A.D. (1999) Kinetics of transhydrogenase reaction catalyzed by the mitochondrial NADH-ubiquinone oxidoreductase (Complex I) imply more than one catalytic nucleotide-binding sites. FEBS Lett. 444:211-216.
  60. Carelli, V., Ghelli, a., Bucchi, L., Monagna, P., De Negri, A., Leuzzi, V., Carducci, C., Lenaz, G., Lugaresi, E., and Degli Esposti, M. (1999) Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy. Annals Neurol. 45:320-328.
  61. Lertrit, P., Ruangvaravate, N., Trongpanich, Y., Imsumran, A., Mungkornkarn, C., and Neungton, N. (1999) Leber's hereditary optic neuropathy (LHON) with mitochondrial ND4 gene mutation (11778) in a Thai patient. J. Med. Assoc. Thai. 82:59-64.
  62. Au, H.C., Seo, B.B., Matsuno-Yagi, A., Yagi, T., and Scheffler, I.E. (1999) The NDUFA1 gene product (MWFE protein) is essential for activity of complex I in mammalian mitochondria. Proc. Natl. Acad. Sci. U.S.A. 96:4354-4359.
  63. Schuler, F., Yano, T., Di Bernardo, S., Yagi, T., Yankovskaya, V., Singer, T.P., and Casida, J.E. (1999) NADH-quinone oxidoreductase: PSST subunit couples electron transfer from the iron-sulfur cluster N2 to quinone.Proc. Natl. Acad. Sci. U.S.A. 96: 4149-4153.
  64. Schuelke, M., Smeitink, J., Mariman, E., Loeffen, J., Plecko, B., Trijbels, F., Stockler-Ipsiroglu, S., and van den Huevel, L. (1999) Mutant NDUFV1 subunit of mitochondrial complex I causes leukodystrophy and myoclonic epilepsy. Nature Genetics 21:260-261.
  65. Okun, J., Lümmen, P., and Brandt, U. (1999) Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). J. Biol. Chem. 274:2625-2630.
  66. Ushakiva, A., Grivennikova, V.G., Ohnishi, T., and Vinogradov, A.D. (1999) Triton X-100 as a specific inhibitor of the mammalian NADH-ubiquinone oxidoreductase (Complex I). Biochim. Biophys. Acta 1409:143-153.

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